📢 Important updates on @flybase.bsky.social @steven-flybase.bsky.social and the team updated #Drosophila enzymes database by adding absent gene ontology annotations and removing or fixing problematic ones. Learn more about these updates in #G3journal: buff.ly/dd3y2pN

Proud of latest publication on #Drosophila #enzymes at doi.org/10.1093/g3jo..., representing several years of diligent work enhancing fly enzyme annotations and display at @flybase.bsky.social and significant improvements of the #GeneOntology.

We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.

Release FB2025_05 of FlyBase.org is live! 'New this release' information is here flybase.org/static/new-t...

So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬 www.pnas.org/doi/10.1073/...

The FlyBoard is happy to announce the call for nominations for the Drosophila Community Service Award. Please submit your nomination by 01/16/2026 by email to: [email protected]. Please repost.

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

There's an update on the state of FlyBase on the FlyBase.org front page. You can contribute to FlyBase at this link wiki.flybase.org/wiki/FlyBase... We express enormous gratitude to the people, labs, groups, and foundations who have already helped us. #FlyBase #Drosophila

Nature has published an article on the crisis facing MODs Model organism databases face budget cuts and closures www.nature.com/articles/d41... @zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com

New metabolic pathway reports too: the GLUCOSYLCERAMIDE BIOSYNTHESIS flybase.org/reports/FBgg..., the GPI-ANCHOR PROTEIN BIOSYNTHESIS flybase.org/reports/FBgg... and the DOLICHYL PHOSPHATE BIOSYNTHESIS flybase.org/reports/FBgg... pathways. #MetabolicPathways

Now the #EDB @flybase.bsky.social representative Katja Röper @katjaroeper.bsky.social is presenting #Flybase future plans

FlyBase will present posters 333 'Modeling the Mitochondrion: Building an Integrated Causal Model for Mitochondrial Processes using the Gene Ontology' and 335 'Building high-quality Genome-Scale Metabolic Models for Drosophila using the Gene Ontology' today at #EDRC2025

Just in time for the #EDRC2025: the #Drosophila metabolic network 'FlyCyc' has been updated at biocyc.org/organism-sum... Come and see poster P-335 on Saturday for more metabolic pathway models at #FlyBase.

The FlyBase situation has made the national news www.nbcnews.com/science/scie...

www.thecrimson.com/article/2025... Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

If you run a fly lab and have not yet contributed to save FlyBase, please look at our wiki page for the latest information!

UK taxpayers who donate to @flybase.bsky.social privately can use Gift Aid if they donate through the University of Cambridge philanthropy site (link below). This increases the value of your donation at no cost to yourself.

Flybase is free to use but not free to make. It takes large teams of people and millions of dollars a year to create the knowledgebas and tools for fly research. Please donate generously.

Our next extraordinary biologist is Norbert Perrimon, a @dmmjournal.bsky.social Editorial Advisory Board member and author of one of @dev-journal.bsky.social's most cited papers. #100biologists @perrimonlab.bsky.social

Also a lot of new #MetabolicPathway reports: NUCLEOTIDE-SUGAR BIOSYNTHESIS flybase.org/reports/FBgg..., HEME BIOSYNTHESIS flybase.org/reports/FBgg..., IRON-SULFUR CLUSTER ASSEMBLY flybase.org/reports/FBgg..., Mo-MOLYBDOPTERIN COFACTOR BIOSYNTHESIS flybase.org/reports/FBgg...,

All proceeds from my #sciart Etsy shop will now be donated to @flybase.bsky.social . Due to fed cuts, this beloved resource that I use daily has lost it's funding, and I'm helping in my small way. Now's a good time stock up on #STEM & #drosophila gifts & swag! www.etsy.com/shop/Picosti...

MassLive.com recently interviewed several Harvard FlyBase people and wrote this news article about the importance of FlyBase: tinyurl.com/4chpts9f

Michael Ashburner FRS was an influential figure in the fields of Drosophila genomics and early sequencing database initiatives such as @ebi.embl.org. Read about their contributions across genetics and bioinformatics in the new biographical memoir: buff.ly/f01zNat @geneticscam.bsky.social‬

After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵

European-based researchers can help support future #flybase curation by donating at this site: www.philanthropy.cam.ac.uk/give-to-camb...

FlyBase needs your help! Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org

This vital resource @flybase.bsky.social is in acute peril: its funding blocked by the vindictiveness of Trump. Emergency funds needed *now*, pending longer term solutions. Personal donations from Europe can be made here (UK taxpayers can gift-aid); other routes also possible. US appeal to follow.

If you haven't heard already: www.thetransmitter.org/community/fl...

#Drosophila @flybase.bsky.social requires emergency funding: "As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!

European Fly PIs: please respond to the email we sent out yesterday and help save FlyBase!

The #Drosophila community can donate to the European side to save FlyBase @flybase.bsky.social at the following link: www.philanthropy.cam.ac.uk/give-to-camb...

Who's calling the shots at NIH? Sworn testimonies and internal e-mails reveal for the first time the breadth of DOGE's control over the world's largest public biomedical funder. DOGE has provided lists of hundreds of grants to cut, and DOGE is now reviewing ALL NIH awards before they're released

This story was possible thanks to NIH employees who reached out; I'm always looking for more sources, so please DM me or find me on Signal (mkozlov.01). PS: If you hit a paywall trying to read the story, making a free account will open up the full story.

Synapse pathway modelling (GO-CAM) #biocuration opportunity at SynGO: werkenbij.amsterdamumc.org/en/vacatures...

FlyBase has added new #MetabolicPathway reports in FB2025_02: NAD(+) BIOSYNTHESIS VIA THE SALVAGE PATHWAY flybase.org/reports/FBgg..., TRICARBOXYLIC ACID (TCA) CYCLE flybase.org/reports/FBgg..., PROTEIN O-GLYCOSYLATION flybase.org/reports/FBgg..., PROTEIN O-GalNAcYLATION flybase.org/reports/FBgg...,

THE PAN-GO #FUNCTIONOME IS LIVE! Read our brand new #openaccess @nature.com paper and explore the PAN-GO Functionome, our most accurate and complete resource ever! Paper links, press release, how to contribute and more on the @alliancegenome.bsky.social Forums: community.alliancegenome.org/t/8343

New #MetabolicPathway Reports include CHONDROITIN SULFATE PROTEOGLYCAN BIOSYNTHESIS flybase.org/reports/FBgg... CHONDROITIN SULFATE PROTEOGLYCAN CATABOLISM flybase.org/reports/FBgg... HEPARAN SULFATE PROTEOGLYCAN BIOSYNTHESIS flybase.org/reports/FBgg...

New publication about #Drosophila paralogs encoding enzymes of carbohydrate #metabolism: www.micropublication.org/journals/bio...

Read the thread for a story that explains, in part, why the community loved having Scott as a part

New #GeneGroups subset: Metabolic Pathways! These manually curated reports aim to facilitate metabolic research in Drosophila by providing high-quality gene lists and visual representations of fly metabolic pathways, integrated with the other rich data in FlyBase.

The new Metabolic Pathway reports on FlyBase provide manually curated, high-quality gene lists and visual representations of #Drosophila #metabolic pathways, integrated with the other rich data in FlyBase. E.g., see the report for GLYCOLYSIS (flybase.org/reports/FBgg...).

The Global Biodata Coalition has an open letter campaign to show support for sustainable funding for biodata resources. Please take a minute to read and decide if you want to sign globalbiodata.org/open-letter-... #biocuration #bioinformatics