I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...

Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...

Congratulations to Claudette Fraire, Kavita Desai, Indumathy Jagadeeswaran, and others, for their work showing how microRNA loss drives a mouse model of a childhood cancer called pineoblastoma! @genesdev.bsky.social genesdev.cshlp.org/cgi/content/...

Nice work Sun, Josh, Tu, and others!

How can new approaches in early detection make a difference for pediatric cancers? In the new episode Believe in Progress podcast, we speak with Dr. Kris Ann P. Schultz, a pediatric oncologist, about how research is reshaping pediatric cancer care: www.youtube.com/playlist?lis...

An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.

H12TORY MADE 🏆

Childhood cancer deaths in the United States have declined six-fold over the last seventy years

Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers? New preprint from the lab! PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor www.biorxiv.org/content/10.1...

Let's build a starter pack for childhood cancer research. Please send a message to be added! 🎗️ go.bsky.app/Tpd9QnM

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

Hello, new friends and old.