🥳 Our preprint is LIVE 🥳 Huge thanks to Lex Tallan and the Stanton lab for another fantastic collaboration! Here, we use zebrafish and MNase-based methodology to show that PAX3::FOXO1 and PAX7::FOXO1 have divergent capabilities for interacting with repressive chromatin states and nucleosomal DNA.

I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...