Jack Kucinski (@jackkucinski.bsky.social)

I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...

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Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function... https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00694-1