1. It was not an accident. 2. It was not a staffer. 3. While the president may have dementia his racism is not due to dementia. 4. He isn’t sorry. He means every racist thought he shares. 5. His base agrees with him. 6. He will do it again. 7. No one in power will hold him accountable.

Not really the "Commissioner's" Priority Review Vouchers, I guess (and not the Secretary's either). On the other hand, I agree it's best for Compass to avoid anything that will cast the pall of politicization over their psilocybin application. www.statnews.com/2026/02/04/p...

This is unreal. An AUSA talking like that in open court is about as close as you can come to a total breakdown. Never heard of anything like it.

Ah yes, the old “you should smile more” every woman has heard at least once (and more likely dozens of times) We do not exist to please you or make you feel more comfortable.

Trump: “I had the nastiest, most vicious joke about John Roberts"..."If you think I’m going to tell that joke you can forget it.”...“I’m going to kiss his ass for a long time." Haha, hilarious, checks and balances are dead and gone. www.washingtonpost.com/politics/202...

The reason journalists are so particular about what’s off the record and about granting anonymity is that many of us take that very seriously. If I promise to protect your identity, I’m not just saying I won’t print your name. I’m saying I will go to jail for refusing a court order to name you.

Join us on February 17, 11-12pm ET as @rachelsachs.bsky.social, @profgenkanter.bsky.social, Chris Meekins, and I discuss "FDA and Its Changing Relationship to Industry" This event is for Health Affairs Insiders only - but if you'd like to attend, let me know! www.healthaffairs.org/do/10.1377/h...

After being held in two of them as a boy, I fought for decades urging America to never again build concentration camps and put human beings in them. It breaks my heart to watch this happen twice now in my own lifetime.

Alex Pretti’s coworkers take a moment of silence this morning

I'm perturbed by the HHS response. Yes, of course we have to speculate when govt regulators fail to follow proper procedures for changing FDA policy. And no, "an open door posture" isn't the same as formal opportunities for public comment/response. Keep your podcasts, give us regs+formal guidance.

Thanks to @jasonmast.bsky.social for highlighting our analysis of FDA's new plausible mechanism pathway in @statnews.com. Key pts: - Plausible mech is a great idea for n of 1/few - FDA needs to stop advancing policy via journal article - Impt open Qs on scope www.statnews.com/2026/01/26/f...

A teacher literally shaking as she describes the threat from her own government to the children she teaches www.theatlantic.com/politics/202...

He wasn't going to a protest. There was no planned protest. It was people in a neighborhood witnessing & recording public actions by secret police. Gun-at-protest is a lie & distraction.

“You cannot bring a firearm, loaded, with multiple magazines to any sort of protest that you want. It's that simple.” — FBI Dir. Kash Patel

Attack = video record Repercussions = execution

The best headline I've seen about MN murder was "Gunmen still at large."

A reminder to the news media: “conflicting accounts” is what you say BEFORE the incontrovertible video evidence appears. After that, your job is to ask why one side is lying, not to repeat the lie and pretend no one knows the truth.

Protesters in Los Angeles projected an anti-ICE video onto the Twin Towers, an ICE-linked detention facility where the Los Angeles Sheriff’s Department actively collaborates with ICE for deportation screenings.

Kare 11 local news just read, in full, this statement from Michael and Susan Pretti, the parents of Alex Pretti. "Please get the truth out about our son."

Noem's lies are mind blowing: "This individual attacked those officers, had a weapon on him and multiple, dozens of rounds of ammunition, wishing to inflict harm on these officers, coming, brandishing like that.

This is courage. Looking a masked, government fascist dead in the eye, face to face, knowing full well that your life is on the line. If elected officials had 1/10th of Alex Pretti's resolve, we would have far fewer troubles.

You could actually structure your moral code around the idea that law enforcement doesn't exist to execute people. You don't have to create perfect victim narratives, you can just refuse to accept that the state gets to kill people.

To put a finer point on it: Republicans have embraced the “insurrectionist theory” of the Second Amendment—the notion that you have a constitutional right to stage an armed rebellion against the government if it becomes tyrannical. Now they’re lining up to say ICE can shoot any armed protester?

DHS lies. They knew there would be video showing plainly that these statements about the man they murdered were absolutely false and they did not care.

So much evil.

What we are watching is a paramilitary force learning that they can kill with impunity, that the regime will smear the victim and defend them. Unless politicians and the legal system exerts accountability, it will not stop. donmoynihan.substack.com/p/past-the-b...

State troopers in riot gear are protecting ICE agents who have long guns. People yelling at the state troopers, “turn around and arrest them! They just killed a Minnesotan!”

That video is horrific indeed. Cold blooded execution.

"Slavery was real" Tiny sign at the base of a brick wall that, until yesterday, held panels about the people enslaved by George Washington. Presidents House, Philadelphia.

Part 2 up now: www.healthaffairs.org/content/fore.... Although the plausible mech pathway is a strong approach for individualized therapies that can't be studied via RCT, in this post, we flag concerns abt scope, identify some impt open Qs + explain why this should not have been posted 1st in NEJM.

Anyone working in feminist and other critical approaches to bioethics with expertise in global health/policy willing to write a blog post for the International Journal of Feminist Approached to Bioethics blog on this? Would love to have your piece on the blog if so.

1 more for FDA folks today. In this pieced led by Sanket Dhruva w/ @dusetzinas.bsky.social + Katherine Phillips, we build on our recent @nationalacademies.org report + argue for further attention to PMRs, surrogate marker validation, rigorous product approval standards, + adequate human resources.

twilight zone

Pulling FBI agents off cartel cases to do minor immigration enforcement, investigating people for protests protected by the First Amendment www.nytimes.com/interactive/...

So much going on right now but for those of you who care about FDA, @pzettler.bsky.social, @stevejoffe.bsky.social, @rachelsachs.bsky.social, @reshmagar.bsky.social + I have a 2 part commentary in @healthaffairs.bsky.social Forefront on the new plausible mechanism pathway. Link to Part 1 below.

You know, there is an option to report icy roads in the Waze app.

How could it be even worse than I thought...

Evil, so horrifyingly evil.

It's a small thing, but it fills me with civic pride to walk through the giant park near my house and see Hmong families having cookouts, Somali parents pushing their laughing kids on the swings. Like, here are people who've endured horrors, and my city has welcomed them in to build peaceful lives.

The writers are never subtle

Every news story about the commissioner's priority review voucher program is more concerning than the last: www.pbs.org/newshour/hea... And Makary apparently "does not use a government email account to do business" 🤯

🧵 Our FDA Task Force commends @fda.gov for delaying the reviews of multiple drugs selected for CNPV when it became clear that safety and efficacy concerns had emerged. But we still need more transparency around the CNPV process. www.reuters.com/sustainabili...

So many important points in Pazdur's remarks but this one is chilling. Under this administration, there's real fear that any show of dissent will be met with weaponized legal attacks. “I hope the IRS doesn’t come and audit me now.” www.statnews.com/2026/01/13/r...

One basic pattern here is that DHS officials are engaging in violence simply because they are irritated at citizens protesting them. There is no plausible threat of violence here. He just wants to inflict pain, and believes there will be no penalty for doing so.

Impeccable timing.

Also, it's not true (per the article) that there's no FDA pathway here. FDA doesn't only regulate products intended for treatment/prevention of disease, it also regulates drugs intended to affect structure/function. The real challenge is proving longevity treatments meet the effectiveness standard.

This study is very important, and it accords with my own observations: When FDA expanded access to mifepristone, it followed the evidence. If anything, it's the continuing restrictions on access that are out of line with the evidence. www.nytimes.com/2026/01/12/h...