Great The Scientist piece: two harmful mutations can restore protein function—challenging how we view genetic risk. I share my take on the structural logic behind this and relevance to drug discovery. My perspective www.the-scientist.com/two-harmful-... Original study www.pnas.org/doi/10.1073/...

Check out our new paper introducing V2P — a method that predicts both variant pathogenicity and disease phenotype across 23 HPO categories. With @itanlab.bsky.social, David Stein, and many other great collaborators www.nature.com/articles/s41... www.v2p.ai

Congrats, @itanlab.bsky.social and David! So happy to see it published

Very comprehensive work on the modulation of mu opioid receptor

Check out this great @cenmag.bsky.social piece by @aayushipratap.bsky.social on how AI is transforming drug discovery. Our work at Mt. Sinai’s AI Small Molecule Drug Discovery Center is featured among others driving this fast-moving field. 🔗 tinyurl.com/sabpvrtp #AI #DrugDiscovery

Interesting read: Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1 www.cell.com/cell/abstrac...

David Baker's Nobel Prize-winning lab has now designed binders to "undruggable" disordered proteins, unlocking therapeutic access to over 50% of the human proteome! ‪@uwproteindesign.bsky.social‬ Read more at GEN: tinyurl.com/4fw6wvkm

Excited to see our new AI Small Molecule Drug Discovery Center #MountSinai featured in GEN! 🧬🧠 Read more: genengnews.com/topics/artif... Thank you @faylinphd.bsky.social #AI #DrugDiscovery #Genetics

Proposed pH-dependent mechanism of the mitochondrial pyruvate carrier. In the outward-open state, positively charged K49 and H86 bind pyruvate, initiating conformational changes to the inward-open state. The high matrix pH deprotonates H86, allowing pyruvate to leave. www.science.org/doi/10.1126/...

We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state! @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Are you aiming for leadership roles in pharmaceutical, biotech, high tech, or medical device companies? Consider applying to the revamped MSBS program @GradSchoolSinai @IcahnMountSinai, featuring 1 or 2-year tracks and non-thesis options tailored for industry professionals

Safeguarding the future of biomedical science in the United States: Cell www.cell.com/cell/fulltex...

At @GradSchoolSinai @IcahnMountSinai, we are excited to train the next generation of #datascience and #AI #professionals for #PrecisionMedicine @MountSinaiNYC and beyond. Apply here: icahn.mssm.edu/education/ad...

Changes in the equilibrium dynamics of kinases can be observed as mutations and ligands are introduced. Authors describe & apply a workflow that combines AF2+MSA subsampling, molecular dynamics simulations, and an autoencoder for dimensionality reduction www.biorxiv.org/content/10.1...

Another outstanding story of the real-world impact of the short-sighted cuts to NIH and other federal support for the best scientific research infrastructure in the world. www.wsj.com/articles/bio...

🚀 #AlphaFold Database update AlphaFold DB now integrates The Encyclopedia of Domains (TED) – a resource designed to systematically identify & classify structural domains within AlphaFold-predicted protein structures. www.ebi.ac.uk/about/news/u... @pdbeurope.bsky.social

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

This is a fantastic meeting for the Cryo-EM community in the NYC area. This year it will take place on the East Coast of Manhattan. Please come and join us!

This is an excellent article that accurately describes the situation with NIH funding. Great work @zey.bsky.social ! www.nytimes.com/2025/02/11/o...

Good morning snowy NYC

If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years. Quantitation and Error Measurements in Dose–Response Curves

Want to become a professor? A huge analysis looks at how criteria assessing researchers for promotion vary widely around the world, and finds some surprises 🧪 www.nature.com/articles/d41...