TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2 Are Transcription Factors really 'undruggable'? www.biorxiv.org/content/10.1...

Why fundamental research is fundamental to progress, seeding major breakthroughs Editorial @nature.com this week And 7 basic science discoveries that changed the world nature.com/articles/d41... nature.com/articles/d41...

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

Opportunity for a Master’s/Bachelor’s student: - Join us for up to 5 months 🗓️ - Build computational/mathematical models 💻 - Learn about genotype-phenotype maps and evolution 🧬 - Work closely with PhD student Manuela Giraud - full info here: www.crg.eu/en/content/t...

🚨JOB ALERT🚨 FRIENDS PLEASE SPREAD and RT We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility. See below 2 calls👇

O maior fotógrafo do Brasil e um dos maiores do mundo descansa hoje. Vá em paz, Sebastião Salgado.

🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.

1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.

 www.biorxiv.org/content/10.1...

 With @benlehner.bsky.social [1/7]