Michael Lazear
@michaellazear.bsky.social
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I like big data and I cannot lie | Informatics/ML lead @ Belharra Tx, wet lab PhD @ Cravatt Lab
reposted by
Michael Lazear
Harrison Specht
4 months ago
๐งช Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper
@parallelsq.bsky.social
is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics ๐
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.05.22.655509v1
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reposted by
Michael Lazear
Brett Phinney
8 months ago
@michaellazear.bsky.social
&
@jspaezp.bsky.social
I'm Running Sage on a dual Epyc 128 thread box w/ 2TB memory (I think) . Searching 19 ddaPASF files directly with built in timsRUST!! Dang this is screaming fast !!
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reposted by
Michael Lazear
Ben Neely
10 months ago
Chiang and Collins making a fun Casanovo + Sage (w/Mokapot et al.) metaproteomics pipeline (Bittremieux,
@michaellazear.bsky.social
@willfondrie.com
) โฆ and an exceptional TOC graphic.
add a skeleton here at some point
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Trying to do some research for buying a new road bike and I have stumbled upon something truly cursed... what appears to a forum of just LLMs talking to one another:
www.cyclingforums.com/threads/gian...
10 months ago
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reposted by
Michael Lazear
Yasset Perez-Riverol
almost 2 years ago
This is Big for
#quantms
team. Let me explain some of the big improvements: - Sage integration thanks to
@michaellazear.bsky.social
- Bruker and library based DIA support thanks to
@jspaezp.bsky.social
- Major improvements in LFQ pipeline and pmultiqc reports. - Lot of bugs fixed from version 1.1.1.
add a skeleton here at some point
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reposted by
Michael Lazear
Ben Neely
almost 2 years ago
Iโve never seen someone with such polished twitter threads, which have now been rolled into a JPR paper. I think
@michaellazear.bsky.social
is on to something great with SAGE, especially its openness. Looking forward to seeing this engine powering proteomics. (h/t
@pastelbio.bsky.social
)
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Sage: An Open-Source Tool for Fast Proteomics Searching and Quantification at Scale
The growing complexity and volume of proteomics data necessitate the development of efficient software tools for peptide identification and quantification from mass spectra. Given their central role i...
https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00486
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