aRukon (@arukon0.bsky.social)

🧬Did you know some skin microbes help protect us from the sun? 🌞🧫 New research shows that UVB light boosts certain bacteria that regulate our immune response. An invisible yet powerful partnership! #Microbiome #UVB #Science #SkinMicrobiome #UVB www.jidonline.org/article/S002...

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Urocanase-Positive Skin-Resident Bacteria Metabolize cis-Urocanic Acid and in Turn Reduce the Immunosuppressive Properties of UVR The skin microbiome plays an important role in health and disease. We have recently shown that microbes living on the skin regulate the immunomodulatory properties of UVR, but the underlying mechanisms remain to be uncovered. Using a preclinical model of immunosuppression against the chemical allergen 2,4-dinitrofluorobenzene, 16S microbiome sequencing, in vitro cultures, high-performance liquid chromatography-mass spectrometry and the generation of gnotobiotic-like mice, we report that acute UVB radiation induces a transient and significant restructuring of bacterial communities on the skin through one of its major photoproducts, cis-urocanic acid. https://www.jidonline.org/article/S0022-202X(25)00405-1/fulltext