It was great that BBC radio 4 covered the harmful effects of finasteride, including persistent sexual dysfunction. More attention is needed to the fact that SSRIs and other antidepressants cause similar, potentially devastating effects. www.bbc.co.uk/sounds/play/...

I agree psychedelics are being pushed now with little regard for the uncertain and potentially negative consequences of repeated use

Super interesting interaction between two esteemed experts of our field. Such important points, especially toward the end where biological reductionism is discussed

See this detailed thread on our paper. In sum, evidence shows fluoxetine has no meaningful effect. Earlier studies influenced by recency bias. But it is still recommended in clinical guidelines

Welcome to the world of "pure" biological psychiatry "MDD is increasingly understood as a disorder of dysregulated neuroplasticity rather than solely of neurotransmitter imbalance" www.biorxiv.org/content/bior... @padbergthorsten.bsky.social @joannamoncrieff.bsky.social @mad-in-america.bsky.social

Do #antidepressants resolve a chemical imbalance or risk creating one? My interview @psychologytoday.com with @joannamoncrieff.bsky.social, author of Chemically Imbalanced #SSRIs #Depression #Psychiatry #MedSky www.psychologytoday.com/us/blog/side...

@joannamoncrieff.bsky.social The 'medicalization of distress, the sedimented belief in “magic bullets,” and the push to “scale up” mental health treatment have contributed to the meteoric rise in the prescription of psychiatric drugs and of polypharmacy tinyurl.com/2az6fc86

In this podcast I talk to therapist, Bruce Wampold, about the science and sociology of the chemical imbalance theory, how emotions are signals and about the potential risks of upcoming treatments for mental disorders, including psychedelics www.youtube.com/watch?v=s7Yu...

In mental health diagnoses are not explanations. 'Sometimes that can be a distraction, because people often try to fit themselves into boxes ..and don't necessarily communicate, or become aware of, what their actual problems are' camdenist.beehiiv.com/p/controvers...

I am delighted to announce that the Spanish translation of Chemically Imbalanced is out now - its called "El mito de los antidepresivos" published by Arcopress almuzaralibros.com/fichalibro.p...

My interview in the Camdenist. We have come to think what we 'need is ever more neuroscience, and that that is somehow going to uncover the answer to everything and tell us who we really are. It is not.' camdenist.beehiiv.com/p/controvers...

@joannamoncrieff.bsky.social Found you! now following having left X. camdenist.beehiiv.com/p/controvers...

No significant effect for ketamine (vs midazolam) in this trial. This contrasts previous research. Functional unblinding and reduced expectancy effects due to the enrolment algorithm likely explain this finding (implying that older research is biased). jamanetwork.com/journals/jam...

🍃 #NatureMatters➡️#EmotionalWellbeing➡️#HousingMatters 🚨Recent studies show that living near #parks or natural #GreenSpace reduces anxiety and depression by about 20 per cent🚨 @housingtoday.bsky.social @heathernstaff.bsky.social @joannamoncrieff.bsky.social www.theguardian.com/money/2025/o...

Universal School Mental Health Lessons Can Backfire, Review Warns A new review finds that universal, school mental health programs can worsen symptoms for some students and urges trials that measure harm as well as benefit. By Ally Riddle www.madinamerica.com/2025/10/univ...

Looking forward to taking part in the HTLGI festival in Kenwood House, London, Sept 20-21st. The line up of amazing scientists, thinkers & political figures including Brain Cox, Roger Penrose, Alastair Campbell, Diane Abbott etc. Tickets howthelightgetsin.org/festivals/lo...

Blog on the longstanding tendency to play down the dependence-inducing effects of psychiatric drugs, now playing out in two reviews that minimise antidepressant withdrawal effects based on flawed studies of short-term users www.psychologytoday.com/us/blog/chem...

When Dr. Roussos-Ross pointed out the dangers of untreated depression, she left out the fact that antidepressants (ADs) have modest efficacy (as later pointed out by @joannamoncrieff.bsky.social ). Bc of the side effects, ADs are associated with a problematic harm-benefit ratio for the majority.

Excellent summary of the ongoing controversy about antidepressant withdrawal issues by @joannamoncrieff.bsky.social www.psychologytoday.com/us/blog/chem...

I was honoured to take part in the FDA's panel on the risks of SSRIs in pregnancy yesterday along with other experts @fda.gov. This is a huge issue with so many young women taking these drugs. I hope the UK and other countries will listen to the evidence presented www.youtube.com/watch?v=2Nha...

It is worrying that leading psychiatrists have quoted the Henssler review regardless of these limitations (and the more recent Kalfas review) to reassure the public and called on the Royal College of Psychiatrists to weaken its advice on stopping antidepressants 4/n

Only 5 studies in the Henssler AD withdrawal review (not 18 as claimed) used a relevant measure of withdrawal. These find 55% of people reported withdrawal symptoms after stopping antidepressant 3/n

The vast majority of included studies in the Henssler AD withdrawal review were not designed to measure withdrawal and only recorded it incidentally among spontaneously reported ‘adverse events’. This is no basis for estimating prevalence 2/n

Remember the 2024 Henssler review claiming only 1 in 6 have antidepressant withdrawal symptoms & 1 in 30 severe symptoms? Here we show it was based on highly unreliable data & can't be used to assess withdrawal effects @ploederl.bsky.social @markhoro.bsky.social 1/n www.cambridge.org/core/journal...

'Psychiatrists have been accused of downplaying the risks of antidepressant withdrawal in a new study' www.thecanary.co/global/world...

Our rapid response in the BMJ highlights how the recent antidepressant withdrawal review confirms withdrawal effects with SSRIs and SNRIs but underestimates their significance due to relying on short-term trials and other methodological problems @ploederl.bsky.social www.bmj.com/content/390/...

Our rapid response to a summary of the new problematic antidepressant withdrawal study has been published, together with other interesting and important ones (e.g., by @markhoro.bsky.social ). @joannamoncrieff.bsky.social

Useful thread on this study

Useful thread critiquing the recent review of antidepressant withdrawal

Occurrence of a discontinuation syndrome in the 5-8 day discontinuation period, defined by Rosenbaum et al. as 4+ withdrawal symptoms: 60% sertraline, 66%paroxetine, and 14% fluoxetine (which can serve as control group). This conforms the ca. 50% occurrence, which was dismissed by Hayes 🤔

Also note that the SMD's for individual SSRI/SNRI's ranged between 0.39 and 0.68. In the study of Rosenbaum, where patients were on antidepressants much longer (average ca. 11 months), the increase in DESS symptoms after stopping meds was 6 and 8 for sertraline and paroxetine, respectively.

Besides the double standards, the main problem is that the result from the main analysis is based on short-term trials (ca 8w) except one 26w agomelatine trial. Not much withdrawal can be expected but was nonetheless observed - concerning! Most are on ADs much longer. Absurd conclusions!

Thread on our response to Ghaemi and how Ghaemi's article became more hostile and pejorative after peer review

I'm looking forward to talking about Chemically Imbalanced in Harrogate at #BerwinsSalonNorth tomorrow evening. Tickets available here: harrogateinternationalfestivals.com/event/berwin... @harrogatefestivals.bsky.social

There’s no strong evidence of a chemical imbalance behind depression, yet antidepressants are still pushed to serve pharma profits and uphold psychiatry’s medical image. @joannamoncrieff.bsky.social's compelling interview. www.youtube.com/watch?v=zcBu...

Liberation Psychology Gains Ground in a Fractured World As crises of displacement and inequality intensify, more scholars are turning to Liberation Psychology’s commitment to structural change. By Micah Ingle, PhD www.madinamerica.com/2025/06/libe...

I am looking forward to giving the Sowerby anniversary public lecture at the Philosophy and Medicine conference in London next Tuesday 3rd June at 4pm. The event is open to everyone, please come along. www.tickettailor.com/events/sower...

This data suggests use of antidepressants may be decreasing a bit in the US - not before time! psychiatryonline.org/doi/10.1176/...

I enjoyed my trip to the How The Light Gets In festival in Hay. My talk was packed out and there were was a good discussion. The festival was a great combination of serious debate and fun

Thought-provoking piece from our next Salon speaker @joannamoncrieff.bsky.social 

#biorisks - SSRI’s are *not ‘selective’, as they affect serotonin used throughout the whole nervous system and where it is used through the metabolic system. Biological system wide mind-body effects. This has been known by pharma research since mid-1950’s

People who have been taking antidepressants for more than two years are more likely to experience withdrawal symptoms compared to short-term users when they come off the medication, finds a new study led by Dr Mark Horowitz and Prof @joannamoncrieff.bsky.social @uclpsychiatry.bsky.social

I enjoyed speaking to Jeannette Hyde in this podcast. We cover the lack of studies on exactly what SSRIs do to the brain, emotional numbing and weight gain, and how exercise and social prescribing fit in thegutmakeover.substack.com/p/research-s...

I am excited to be appearing at the How The Light Gets In festival at Hay this weekend with other stellar guests including @yanisvaroufakis.bsky.social, @jeremycorbyn.bsky.social, @slavojiek.bsky.social, @sapinker.bsky.social and others. Tickets here: howthelightgetsin.org/festivals/ha...

🔔 NEW in the Medical Journal of Australia Antidepressant prescribing in Australian primary care: time to reevaluate ✍️ Katharine A Wallis, Anna King and Joanna Moncrieff buff.ly/6KQAiTe

This podcast critiques the dominant disease-based model of psychiatry, arguing that psychiatric diagnoses and treatments—especially the serotonin imbalance theory—lack scientific basis and have caused widespread harm. With @joannamoncrieff.bsky.social on @mad-in-america.bsky.social buff.ly/cGvS8tu

If you are in or around London next Wed, come along to my talk at 6.15pm at the Reconnect Club hosted by the inspiring @joetudor.bsky.social. www.eventbrite.co.uk/e/chemically...

"Yet, there is evidence from primary care that people are prescribed antidepressants when clinical guideline criteria are not met, more commonly women", write Katharine Wallis, @annaking1.bsky.social and @joannamoncrieff.bsky.social #Psysky #madsky

This is probably the best estimate we have for this condition so far