Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗 🦟 Transgenic parasites without Pfs230 D13D14 do not transmit 🦙 💉Nanobodies + mRNA induced antibodies reduce transmission New in @Science.org www.science.org/doi/10.1126/... #ScienceResearch #Malaria #WEHI

The battle of the decades is complete. Thank you Leann Tilley for the excellent chairing and all the speakers for a fun session. @lorneproteins.bsky.social

James Whisstock takes us to the present day highlighting some of the coolest techniques presented at #Lorneproteins in the past decade.

A Protein structure was not enough to get a talk by the early-mid 2000s (unless it was a membrane protein :-) ) Jacqui Matthews @lorneproteins.bsky.social

Protein missing is pretty important - Robin Anders @lorneproteins.bsky.social

Marilyn Anderson reminisces on the beginning of Protein design in the late 80s #Lorneproteins @lorneproteins.bsky.social

Lindsay Sparrow tells us there was only 23 structures in the PDB when #Lorneproteins started in 1976! @lorneproteins.bsky.social

Congratulations Frances Separovic on winning the Leach Medal - #lorneproteins

Deb Leach sharing her thoughts on her father, Syd Leach, who started #Lorneproteins

The 50th Lorne Conference on Protein Structure and Function - Beautiful Welcome to Country #lorneproteins

Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy https://www.biorxiv.org/content/10.1101/2024.12.22.629940v1

Scalable emulation of protein equilibrium ensembles with generative deep learning www.biorxiv.org/content/10.1... No code is available yet, but sounds huge. Effectively does MD-sim, but fast!

ICYMI: this really interesting @science.org paper on possible underlying mechanisms of post-accute #COVID19 syndrome ( #PACS ) aka " #LongCOVID" from last January!

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells www.nature.com/articles/s41...

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1

Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1

Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1... New from the Baker lab

A major step forward toward high-resolution nanopore sequencing of full-length proteins www.cell.com/molecular-ce...

C/O the #adelaideproteingroup The Lorne Proteins Conference 2025 is coming up! Feb 9–13, 2025, it’s a must for protein science enthusiasts. 🇦🇺 Lorne, Victoria 💡 Connect with international experts, share your research, and explore the latest advancements. 📅 Register now: lorneproteins.org