Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime www.youtube.com/watch?v=tdNn...

Really excited about this work! We hope Fast NMR scoring can contribute to drug discovery. Thanks Dusan Uhrin @edinburghchem.bsky.social and Ridvan Nepravishta @rnepravishta.bsky.social @crhorizons.bsky.social for getting us on board of this collaboration. @csic.es pubs.acs.org/doi/10.1021/...

Big congrats to Jona for his successful defence of his PhD Thesis. Thanks to the panel @albasilipo.bsky.social Paco Corzana, Pedro Nieto, Victoria Gómez and Miguel A. Rodríguez Carvajal. Great NMR cake for the celebration!!! @csic.es

A heads-up: Friday 5th 11am, first PhD defence in the @angulo-lab.bsky.social since the lab move to Seville. It'll be at cicCartuja @csic.es. Jona's presenting his work on some pretty cool new STD NMR approaches for low-affinity biomolecular interactions. Co-supervised with Juan C. Muñoz-García.

#bioGUNE_Talent | 👏 Óscar Millet #CICbioGUNE @brtaeus.bsky.social, appointed Vice President of @group-ampere.bsky.social, Europe’s top #NMR organization, the first Spanish scientist to hold this role 🎉 Congratulations, Óscar! 🔗 ow.ly/hxi450Wuwiw

Great week of science in Bilbao @ XL Meeting of the Spanish Royal Society of Chemistry @rseq-quimica.bsky.social. I really enjoyed presenting our developments in Epitope-Perturbation-by-Mutation STD NMR spectroscopy in my invited talk. It opened great discussions with fantastic colleagues. @csic.es

On our way to Jaca #NMRschool #ManuelRicoNMR #NMR2025

Starting our mid-term meeting @GlyCanDrug at @i3S_UPorto in Porto. Putting together the glycoscience we're developing in our European Doctoral Network

Registration to our "Structural Glycoscience" Summer School is open !! Come to Grenoble for #glycotime lectures, practicals, visit to @esrf.fr @cermav.bsky.social and IBS. Information and registration at glycoalps.univ-grenoble-alpes.fr/news/summer-...

Our famous "Structural Glycoscience" summer school is back in June 2025 in Grenoble !! with @angulo-lab.bsky.social @elisafadda.bsky.social @glycoexpasy.bsky.social @romain-vives.bsky.social and many others. Attendance is limited to 40 so register quickly !

Our first paper on STD NMR Epitope Perturbation by Mutation: Unveiling Mechanism of YM155 as an Arginine-Glycosyltransferases Inhibitor Effective in Treating Enteropathogenic Diseases pubs.acs.org/doi/10.1021/... Great collabor. Ramón Hurtado, Weston Struwe, Valeria Calvaresi, and Philip Hardwidge

A privilege to have my former boss Thomas Peters visit our research group in Seville @csic.es, as an invited speaker at the III @GlycoNoVi Workshop.

Excellent scientific discussions today!! III workshop of the "GlycoNoVi" MSCA-DN European Network in Seville. We thank cicCartuja @csic.es for kindly hosting our meeting at the research centre. (#MSCA-DN)

Proud of @faezehjame.bsky.social and our latest paper on upregulation by #miRNA. miRNA upregulate protein expression of CD98hc, ST3GAL1 and ST3GAL2 in a coordinated manner. Regulation is bidirectional, changing the picture on how these #RNA work. #glycotime www.science.org/doi/10.1126/... 🧪

Today, we officially welcome Pablo Valverde to the group, working on our @csic.es MOMENTUM project. Starting gun fired for exciting computational+NMR times to characterise challenging weak protein-ligand interactions.

RIP J. Fraser Stoddart and Martin Karplus.

Attention recent PhD's (thesis finished in 2023 or 2024): the ‘Juan de la Cierva’ call is opening. 2 year postdoc contract! Interested in molecular recognition for development of new drugs (NMR spectroscopy, computation, AI, biophysical techniques)? Contact us! www.aei.gob.es/convocatoria...

Xmas is coming to the lab...

Fancy glycan of the week 🍬: here ⬇️ is THE fanciest tetrantennary+SDa antigen bisected N-glycan I have ever seen! Found in bovine pregnancy-associated glycoproteins (PAGs) during midpregnancy, see doi.org/10.1093/glyc... This (and its core-fucosylated companion) will be soon on glycoshape.org 😀👍

#PhDposition available in my group at the @mpici.bsky.social! Join us to develop new #carbohydratematerials #chemistryjobs #researchjobs #glycotime jobs.mpikg.mpg.de/jobposting/a...

I am very proud to share a long story on lectins and biofilm imaging just published in JACS Au by Eva and Lisa in cooperation with many colleagues such as @anneimb.bsky.social 😍 #glycotime #chembio #AMR please have a look here: pubs.acs.org/doi/10.1021/...

This was an amazing collaboration with high affinity ligand for Pseudomonas aeruginosa lectins able to target the bacteria in mice !! #glycotime 🍾

Perspective by Higman et al: deposition of data for titrations, relaxation rates, PREs, etc in a standardized way, e.g. the NEF format could help develop AI models to accurately predict the dynamic behaviour of a protein from the primary sequence alone. #NMRchat doi.org/10.1007/s108...

🎄 Exciting News for NMR Enthusiasts! 🎄 This December, join us for an NMR Advent Calendar! 🧪📅 New challenge unlocked on our website each day. 🔓 Starts Today - 1st of December 💻 Visit: nmr.chemistry.manchester.ac.uk/advent24 🎁 Test your knowledge, learn, and have fun! #NMRchat #AdventCalendar

Sunday coffee time dilation... What a beautiful view!! 😍

Postdoctoral Position at the University of Gothenburg (Sweden) – Developing AI tools for Biomolecular NMR and Structural Biology, posted 11/26/2024 listes.services.cnrs.fr/wws/arc/nmr/... #NMRjobs #NMRchat #NMR 🧲

If you have the right profile 💻, you should seriously consider this offer as a once-in-a-lifetime opportunity. Manuel is not only an exceptional scientist, but also—and this is crucial for potential students and postdocs—a kind person who cares about his people.

X has copied the starter pack concept 😂

I am happy to share the preprint of a review coordinated by my colleague Giacomo Parigi on relaxometry of biomolecules systems. doi.org/10.26434/che...

Awesome webinar by @elisafadda.bsky.social at GlyGen. series. Everything you should know for building the GLYCO of your glycoproteins with GlycoShape (glycoshape.org)

Proud of Henry Flatau, PhD student of our group after being awarded the Prize for Best Oral Presentation at the PhD Students Congress at the Chemistry Faculty of the University of Seville. NMR spectroscopy, computational chemistry & (bio)molecular interactions.

It was a great privilege to chair the ChemBio VII conference (www.chembiovii.es) held in Seville. The organizing committee worked very hard to make the meeting a success. Amazing contributions and discussions in Chemical Biology with colleagues, with the beautiful Seville as a backdrop.

Congrats to @delbiancom.bsky.social for winning the "European Award for Young Research Leaders of the Spanish Specialized Group of #ChemicalBiology"! Read how she designs synthetic #glycans to explore their untapped potential for #MaterialsScience ➡️https://tinyurl.com/4nxd5s6b #skychem

Grateful for the opportunity to be able to present and discuss our work at ChemBio VII in Seville. Thank you to Jesus Angulo for the kind invitation- and also for taking this photo!

If you are interested or working in #structuralbiology, as you see any protein (yes, *any*), you should be thinking: is it glycosylated? The answer is likely to be yes! You can predict N-glycosylation sites and rebuild all types of glycans with ReGlyco glycoshape.org 😌 Check out the example ⬇️ 1/2

White and red "matured grape juice" to celebrate meeting, after many years, former members of the lab Serena Monaco and Ridvan Nepravishta in Seville. Happy to see them doing, and looking, so well! www.chembiovii.es/CHEMBIOVII2024

The Angulo lab working hard to have everything ready and in place for the ChemBio VII Meeting this Monday in Seville (www.chembiovii.es/CHEMBIOVII2024 )

Here is a great opportunity to join YSBL (York) and work with @mjplevin.bsky.social and myself! www.findaphd.com/phds/project...

Interesting piece about glycosylated RNAs (glycoRNAs): sialylated glycoRNAs are present in human cell lines, and sialylation of glycoRNAs depends on the catalytic isoforms of the oligosaccharyltransferase (OST) complex. tinyurl.com/vhz2rj8a

Here below is a slide summarising all that you can do with glycoshape today! And so much more to come soon! Any questions/feedback please let us know! 2/2

As we (my lab and I) are new here 😻, let me introduce some exciting #glycotime work we recently published in Nature Methods doi.org/10.1038/s415... GlycoShape is a completely OA database and toolbox to restore the 3D structure of glycans on glycoproteins 🥳 You can find it at glycoshape.org 1/2

The Society for #Glycobiology has awarded its Distinguished Service #Award to the editors of "Essentials of Glycobiology", including our Director, Peter Seeberger. ➡️ academic.oup.com/glycob/artic... (end of page) #glycotime

Hello everyone!! New in this BlueSky... I share with you our study on the IT-sialidase from R. gnavus RgNanH-GH33. Brilliant collaboration with Nathalie Juge (Quadram Institute, Norwich), and all the work led by Serena Monaco (UEA, Norwich). www.sciencedirect.com/science/arti...