(1/7) How does T. brucei achieve a 140-fold stoichiometric excess of VSG mRNA over upstream ESAGs from a single polycistronic unit? Our latest research in @natmicrobiol.nature.com reveals a mechanism of spatially regulated RNA decay to fine-tune expression of virulence genes

Out Now! Specialized RNA decay fine-tunes monogenic antigen expression in Trypanosoma brucei #MicroSky

Newest collaborative paper out now on biorxiv - new genome and VSG arrangements in T. congolense, excellent work by Marija! In the words of @scotomorph.bsky.social T. congolense ≠ T. brucei www.biorxiv.org/content/10.6... @rmc9z.bsky.social @keithrmatthews.bsky.social

De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei https://www.biorxiv.org/content/10.64898/2026.02.19.706783v1

New from the Horn Lab at the University of Dundee www.nature.com/articles/s41...

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. www.cell.com/cell-reports...

So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!

New paper @uofgsii.bsky.social led by @scotomorph.bsky.social @marquescata.bsky.social where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome, including stability. Well done Marija, and thanks all co-authors! doi.org/10.1038/s414...

New preprint from others in the lab - Mapping origins of DNA replication in Leishmania. Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss! www.biorxiv.org/content/10.1...

Extremely excited to meet former colleagues from my PhD, other BoP 2019 @mblscience.bsky.social alumni, old friends and colleagues, as well as many new!