We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social www.sciencedirect.com/science/arti...

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. www.cell.com/cell-reports...

More recent work from the McCulloch lab! Check out Jeziel's @jezieldamasceno.bsky.social recent paper on R-loops, DNA replication and genomic stability in Leishmania major www.nature.com/articles/s41... in @naturecomms.bsky.social @rmc9z.bsky.social @marquescata.bsky.social

Please enjoy a new paper led by @jezieldamasceno.bsky.social that reveals how R-loops and their homeostatsis through RNase H1 modulate Leishmania DNA replication timing @uofgsii.bsky.social @marquescata.bsky.social @scotomorph.bsky.social www.nature.com/articles/s41...

Excited to share our latest work on R-loops and RNAse H1, exploring their roles in genome replication timing and stability. It’s now published! www.nature.com/articles/s41... @rmc9z.bsky.social @marquescata.bsky.social @scotomorph.bsky.social

Fancy a sneak peek into Leishmania’s unusual DNA replication programming? At the McCulloch’s group we used D-Nascent to map origins & forks at the single-molecule level, revealing novel, abundant replication initiation events across its plastic genome. See links below👇