New UniDec release: github.com/michaelmarty... Lots of bug fixes, improvements, and some under the hood changes to get ready for future features. A few cool new features. More notes in thread

To everyone doing cool data analysis stuff, I'd love to see some analytical chem applicants in this search! Please pass along.

We invite applications for tenured faculty in any area of experimental physical chemistry. apply.interfolio.com/174607

Assuming the voltages are correct, has anyone ever had issues running a 15 A mass spectrometer on a 30 A circuit?

We've got a new MassSpecCodingClub module posted. The videos are linked here: github.com/michaelmarty... This module teaches how to parse FASTA files and read/write Pandas DataFrames. We explore an application of converting DDA data into an MRM transition list. Enjoy!

Anyone know of a nitrogen pressure booster that can bring the pressure up from ~90 psi to ~110 psi?

New review article from Hiruni and Farhana on MS of membrane proteins in the context of biotherapeutics: doi.org/10.1002/9781... (Preprint link here: doi.org/10.26434/che...)

A Fast Neural Network for Isotopic Charge State Assignment #JACS pubs.acs.org/doi/10.1021/...

Excited to have this published in @jacs.acspublications.org! IsoDec is a new neural network for charge state assignment with high-resolution MS data. We test it for top-down proteomics. It's free and fast, what else could you want? pubs.acs.org/doi/full/10....

Two new IsoDec tutorial videos to go over top-down proteomics searching with a few different workflows, one with TopPIC and the other with MetaMorpheus @metamorpheus.bsky.social : youtu.be/OTQbplEezLQ and youtu.be/56OZJph48BU

I am thrilled to share after years of work/procrastination that the MassQL manuscript is finally published in @natmethods.nature.com - "A universal language for finding mass spectrometry data patterns". This was an team effort from all co-authors that helped shape MassQL and how it could be used.

Check out the latest tutorial video, from Marty Lab postdoc John Pavek, on how to analyze individual spectra with IsoDec, our new neural network for isotopic deconvolution: youtu.be/aOR37-j28NI

Would anyone be interested in me holding a UniDec/IsoDec office hour at ASMS this year?

Well, the USA may be getting worse, but UniDec is getting better. Check out the new version here: github.com/michaelmarty... Mostly bug fixes. I'd love some people to try it out and let me know how it works on their computers. Hopefully it fixes issues with it getting blocked by antiviruses

New paper from the group! Our first with MD simulations included. Congrats to Hiruni and Farhana, who worked really hard on this! pubs.acs.org/doi/full/10....

New preprint from the lab on IsoDec, our new neural net for isotopic charge state assignment: chemrxiv.org/engage/chemr...

Does anyone have recommendations for good lab moving companies?

Very excited to share this commentary written by Chae, Daniel, and myself about navigating the postdoc experience. This started out of a discussion in a @femalesinms.bsky.social pod last year. Enjoy! pubs.acs.org/doi/10.1021/...

The first @asms.org Winter Conference in Santa Fe is in progress. An intrepid group of skiers and snow boarders took to the slopes at #SkiSantaFe for some free afternoon fun! #TeamMassSpec

Really excited to release a beta version of UniDec 8.0! The coolest feature is a new AI-based charge assignment for isotopic resolution data. It's performing a little better than Thrash/Xtract but way faster. Try out IsoDec if you are doing top-down! github.com/michaelmarty...

It’s official! The Marty Lab will be moving to Austin this summer. Looking forward to the new adventure!

New paper from the group combining separations with CD-MS using Hadamard transform multiplexing: pubs.acs.org/doi/full/10....

Coupling online size exclusion chromatography with charge detection-mass spectrometry using Hadamard transform multiplexing chemrxiv.org/engage/... --- #proteomics #prot-preprint

New paper from the group describing UniChromCD for time-resolved CD-MS data, especially with fancy demultiplexing strategies! Great work Skippy and team! pubs.acs.org/doi/full/10.... As always, the software is open-source and free

Combining Fourier Transform Ion Mobility with Charge Detection Mass Spectrometry for the Analysis of Multimeric Protein Complexes chemrxiv.org/engage/... --- #proteomics #prot-preprint

Finally excited to share our recent paper in Anal. Chem. using mutant cycles and native MS to study lipid binding: pubs.acs.org/doi/full/10.... Congrats to Hiruni, Farhana, and Megan on their hard work! Looking forward to seeing what's coming next!

New preprint from postdoc Skippy Sanders using multiplexed Hadamard transforms injections to interface SEC with CD-MS! He'll be talking more about it at #ASMS2024 (ThOE) and our undergrad, October, will be talking about masked multiplexing with HT-SEC-CD-MS on MOE: doi.org/10.26434/che...

Latest paper from the Marty Lab. Short summary: SARS-CoV-2 E protein forms a dimer, HIV Vpu forms a range of variable oligomers, Polio VP4 never oligomerized in our hands. Congrats to the Julia and the rest of the team! pubs.acs.org/doi/full/10....

New set of #MassSpecCodingClub modules posted: github.com/michaelmarty... Free videos to learn coding for MS applications. Take a look and let me know via the discussion what ideas you have for future projects.

I think we found the oldest thing in our lab. A nitrogen gas cylinder says "US Army Air Forces", which means it may be more than 76 years old. Pretty cool!

New paper with collaborators at Thermo. How do to online buffer exchange on membrane proteins in detergent micelles and nanodiscs. Enjoy! pubs.acs.org/doi/full/10....