Theo Crosson
@theo-crosson.bsky.social
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Post-doc, Ugolini lab, CIML. Peripheral neuro-immune interactions.
www.annualreviews.org/content/jour...
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Neural Regulation of Skin Immunity
The exploration of neuroimmune interactions at tissue barriers has become pivotal for our understanding of how organisms survive and adapt to challenging environments. Serving both as a physical barri...
https://www.annualreviews.org/content/journals/10.1146/annurev-immunol-082924-065052
2 months ago
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Theo Crosson
Immunity
12 months ago
Our special issue on
#neuroimmunology
is online! Check out the collection, with reviews from
@jonykipnis.bsky.social
@michellemonje.bsky.social
@ugolinis.bsky.social
@bethstevenslab.bsky.social
@movahedilab.bsky.social
Matteoli, Butovsky, Kim, Artis, & Prinz!
www.cell.com/immunity/col...
#AAI2025
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Happy to share our latest review ! Published today in
@cp-immunity.bsky.social
. We explore how sensory neuron diversity affects various peripheral immune responses.
www.sciencedirect.com/science/arti...
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Role of specialized sensory neuron subtypes in modulating peripheral immune responses
The immune and sensory nervous systems detect diverse threats, from tissue damage to infection, and coordinate protective responses to restore homeost…
https://www.sciencedirect.com/science/article/pii/S1074761325001712?dgcid=coauthor
12 months ago
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Theo Crosson
Alex Chesler
12 months ago
co-author
@dimacd.bsky.social
pointed out that the link was truncated in my post. Hope this works:
www.nature.com/articles/s41...
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A distributed coding logic for thermosensation and inflammatory pain - Nature
Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing p...
https://www.nature.com/articles/s41586-025-08875-6
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Theo Crosson
Will Aisenberg
12 months ago
We used microglia replacement to understand the therapeutic and pathologic roles of macrophages in a genetic brain disease 🧠A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️
www.cell.com/immunity/ful...
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Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00138-4
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Theo Crosson
Will Aisenberg
12 months ago
Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace. Congrats to first author Jonathan Bastos!
add a skeleton here at some point
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Theo Crosson
eLife
about 1 year ago
Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel.
buff.ly/ypISrtx
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Theo Crosson
Akiyuki Taruno
about 1 year ago
✨New paper from my lab out now in
@cp-cell.bsky.social
! We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltex...
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Theo Crosson
Patrik Ernfors
about 1 year ago
How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.
www.nature.com/articles/s41...
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Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience
Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...
https://www.nature.com/articles/s41593-025-01921-6
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Theo Crosson
Waggoner Lab
about 1 year ago
Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice
@cellcellpress.bsky.social
cell.com/cell/fulltex...
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Theo Crosson
Waggoner Lab
about 1 year ago
Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of NK cells
www.nature.com/articles/s41...
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Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells - Cell Research
Cell Research - Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells
https://www.nature.com/articles/s41422-025-01098-4
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Theo Crosson
Geoffroy Laumet
about 1 year ago
🚨 Exciting news! Our study reveals that mast cell-derived chymases contribute to the resolution of inflammatory pain. Thanks to @NIH funding, we’re taking a step closer to non-addictive pain therapies! 🔬💡
#Neuroimmunology
#PainResearch
#Science
pubmed.ncbi.nlm.nih.gov/40035664/
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Theo Crosson
ImmuNoah's Ark (Noe Rodriguez)
about 1 year ago
Really interesting paper! Postprandial parasympathetic signals promote lung type 2 immunity: Neuron
www.cell.com/neuron/fullt...
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Postprandial parasympathetic signals promote lung type 2 immunity
Chen et al. report on the feeding-induced enhancement of lung type 2 immunity in the mouse models of asthma. This phenomenon depends on postprandial parasympathetic signals, which act via the choliner...
https://www.cell.com/neuron/fulltext/S0896-6273%2824%2900919-X
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Theo Crosson
Waggoner Lab
about 1 year ago
GABA production by enteric neurons suppresses ILC3 activation to prevent inflammation and maintain gut homeostasis
@natimmunol.bsky.social
N&V by
@hepworth-lab.bsky.social
www.nature.com/articles/s41...
on
www.nature.com/articles/s41...
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Theo Crosson
Dan Kaplan
about 1 year ago
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at
#science
#neuroimmune
#immunology
www.science.org/doi/10.1126/...
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Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
https://www.science.org/doi/10.1126/science.adn9390?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=SCIeToc&et_rid=17785528&et_cid=5512612
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Cytokines reprogram airway sensory neurons in asthma: Cell Reports
www.cell.com/cell-reports...
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Cytokines reprogram airway sensory neurons in asthma
Nociceptor neurons play multiple roles in asthma by exacerbating inflammation and bronchial hypersensitivity and triggering mucus metaplasia. Crosson et al. characterize a distinct subset of NPY1R-exp...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2824%2901396-2
about 1 year ago
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