Bichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists. arxiv.org/abs/2512.12467

let's talk in person! but fwiw I personally think that we talk about dimensionality! to me the important ideas within the neural manifold framework are: (1) manifolds reflect biological constraints, (2) capture population-wide functions/computations, (3) manifolds (may) have ontological power

🤩 + impressive answer 🧭🚕 @ 2:50 “Trust me, knowledge is power” 💀 This is my guy.

Good resp to Bhattacharya, noting the agenda of The Spectator. When we rebut Trump attacks on science it’s good to talk about his agenda and the agenda backing him—he was selected for the job by donors who want to privatize federal funding and use science as a wedge issue to get votes for thr side.

www.science.org/doi/10.1126/... damn this is so very clever! "... we investigated how the brain categorizes stimuli that are not linearly separable in the physical world ... The sensory manifold was ... expanded into a seven-dimensional perceptual manifold..."

Human multipatch L2/3 functional cell types. LFG. 🧠📈🧪

Tolerance has gone too far. Researchers should date other people, in my opinion

Landmark paper from @srheilbronner.bsky.social and colleagues! www.cell.com/trends/neuro...

Last day to register for the 50th anniversary meeting Jan 8-11: parkcitywinterconf.org/register/ Historical perspectives from Lynn Nadel, Os Steward, Jim McClelland, and topics from synaptic plasticity to neural circuit dynamics of learning and memory systems to aging and dementia. #neuroskyence

Nice thread (and nice recognition for @trackingactions.bsky.social!)

We give examples for less striking number of neurons here. For different species, tasks, and brain areas, it's always the same observation: PCA overestimates the dimensionality -except for one very simple task- and this overestimate gets worse w the number of neurons www.biorxiv.org/content/10.1...

📣Register now for the 50th Anniversary Park City Winter Conference on the Neurobiology of Learning and Memory parkcitywinterconf.org/register/ Deadline tomorrow, Friday, the 12th! Spread the word. 🧠🔬👩‍🔬 ➡️Top 5 reasons to attend: 1/6

correction: he *is* reviewer #3

Keep in mind, we could have already advanced so much in this field if, for political reasons, mRNA vaccines were not severely attacked over the past 5 years. We are closer than ever to a cure for #MultipleSclerosis, and that involves preventing #EBV from damaging the brain.

🚨New publication! I am extremely happy to share this new review article in elife on #Traveling_Waves! @erc.europa.eu @upcite.bsky.social elifesciences.org/articles/106...

I wrote this last week with the news of the shutdown deal, about why we need a lot more to save US science. Comments and questions are welcome. ------------------- As a US scientist and NIH employee, I had mixed feelings about the reopening of the US government this week. 1/

Happening now ss3 ss4 dentate spikes, beta, category learning in freely moving 🐒

For those coming to SfN, I’ll be giving a talk showing evidence of hippocampal neuronal replay 🎞️🔁 in HUMANS as part of the “Representation of Time in the Brain” minisymposium (Wednesday morning) Our stellar group of speakers also wrote a preview of the session in @sfnjournals.bsky.social #sfn2025 🧠

Good morning #SfN25! Looking for some posters to see this afternoon? Check out two by our lab: GG15 and HH1 🧠🧪👩🏻‍🔬

Make sure to add this event to your #sfn25 schedule 👇 #animalResearch #transparency #neuroscience

Sad to miss the rest of this session, but excited to go meet with the brainfacts.org team. We have a lot of exciting new results in brain/mind research to unpack (yeah!) as well as a disturbing amount to misinformation to combat (sigh). If you aren’t following @brainfacts.org, you must!

How our foray into acute neural recordings from the frontopolar cortex started. Check out Kati Rothenhoefer’s LBP028 poster this afternoon (11/16) to learn about how it’s going. #sfn25 #sfn2025

Come hear about state-driven neural complexity today #SfN25 PP13 - "Deep cortical layer stimulation reveals state-dependent changes in neural excitability" Poster Session 1-5 pm Computational Approaches & Experimental Analyses I

🧬 Evolution meets neuroscience at #SfN25! Learn how multi-omics approaches are revealing how evolution acts on cell types, underpinning neural circuitry and behavior changes across diverse species. 📅 Tues., 11/18, 9:30am–12:00pm 📍 Rm 6CF 📲 https://www.abstractsonline.com/pp8/#!/21171/session/1213

And I’m a big fan of Turing, von Neumann, Shannon, Metcalfe, Hinton, Sejnowski, and all the other algorithmic and computation people. No shade. But data limits still limit understanding of the brain. That’s why the #NIH US BRAIN Init was so important: public investment made new tools.

Landed at #SfN and we have lots of fun new results to share. See below for Yassalab poster presentations. If you want to talk #Alzheimers or #mentalhealth come chat with us. #SfN25 #neurosky #neuroskyence #academicchatter

Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers. I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research. As @jenna-m-norton.bsky.social put well: 1/

@markhisted.org , you have been and are incredibly brave and admirable. I hope the rumors are false. and: keep up the amazing work!

BREAKING: In AAUP et al v. Trump (wall-to-wall union lawsuit challenging the administration’s unlawful use of TItle VI to reshape the University of California system), the faculty and staff of the UC system WON!!! We were granted our preliminary injunction! @aaup.org

Going to #SFN2025. Check out the Costa Lab posters on Sunday and Monday afternoon!

Here are our contributions for #SFN2025 #SFN25, Sunday and Monday morning. Hope to see you there!

The Society for Neuroscience meeting starts tomorrow! I prepared some microscopy images for display at the convention center in San Diego. Let me know if you see one of my images around! 🤓 🔬 🧠 @sfn.org #SfN25 #FluorescenceFriday

He’s not kidding- I predict he’ll be putting the “special” in Presidential Special Lecture. Bring popcorn.🍿

Please also follow @safa-science.bsky.social for more updates

A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions. A bit of a video explainer here: 1/ 🧪

The Preston Lab will be at @sfn.org #SfN2025! Come see what we've been working on 🧠 We'll discuss how kids & adults remember when things happen, how memory changes impact reasoning & how we learn different actions have different consequences based on the setting. Find us Monday & Wednesday 🤘

Miller Lab at #SFN2025. Come by and say hi ya. #Neuroscience

“Of all the words spoken in opposition to, or aghast at what’s happening in the United States, only one set of remarks has rattled in my head day after day, for going on a month now.” Compelling and insightful article today from @brianbeutler.bsky.social 1/

Our preprint about Neuroinflammation in #LongCovid is online! This group met during the community-driven event #UnitedtoFight last year. This publication in #NeuroCovid is just another example of how science works better when we listen to the community and work together with them! (1/3)

i love it!

Since this is going around again, figured I'd add the more hopeful addendum that encourages scientists to keep doing their important research and to speak out about the current attacks on US science. rdcu.be/emD0Z

🚨New in @cellpress.bsky.social We discovered that hippocampal replays in natural-scale environments are highly fragmented, not full-length. doi.org/10.1016/j.ce... 👇🧵

I just signed the Bethesda Declaration and urge you to do the same today, so that we all stand with NIH researchers as Battacharya appears before the Senate Appropriations Committee tomorrow.

Signed. Read and spread:

New Op-Ed in the Guardian regarding the new "Gold Standard Science" Executive Order. From @cdelawalla.bsky.social @carlbergstrom.com @briannosek.bsky.social @michaelemann.bsky.social, Carol Greider, and Victor Ambros. www.theguardian.com/commentisfre...

📌New bio constrained ANN learning rule: ➡️dendritic target propagation⬅️ considers cell diversity, compartmentalization, FF FB inputs, more. 🧠📈🤖🧪

7/7) As a final thought for funding, particularly for younger scientists, I am a strong advocate for the NSERC Discover Grant model: - Smaller grants, with high success rate (~50%) - Only one grant per lab - Young researchers do not have to hit the same bar as established researchers to be funded

👀Interesting take from @stephanie-theves.bsky.social linking general intelligence and abstraction. One to watch. 🧪🧠📈🧠🤖🧠👩‍🔬 _ ?(emoji analogies seemed fitting)

🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!

America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.