Belen Pachano
@belenpachano.bsky.social
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📥 283
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Postdoctoral researcher studying Trypanosoma in the Siegel lab 🧬 From 🇦🇷 → 🇫🇷 → 🇩🇪
pinned post!
I’m excited to share our new preprint! We’ve been investigating a specific domain in TgSNF2L that forms decamers in vitro. Every time we attempted to break them apart, they just snapped back together. That tenacity earned it the nickname Hydra. 🐉 🔗
www.biorxiv.org/content/10.1...
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Hydra domain drives SNF2L multimerization and marks ISWI diversification in parasites
ISWI chromatin remodelers are conserved regulators of nucleosome positioning and chromatin accessibility across eukaryotes, yet their evolutionary diversification is poorly understood. In the apicompl...
https://www.biorxiv.org/content/10.1101/2025.09.03.673926v1
5 months ago
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reposted by
Belen Pachano
Mohamed-Ali HAKIMI
3 months ago
Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in
#Toxoplasma
&
#Crypto
www.nature.com/articles/s41...
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Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications
Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...
https://www.nature.com/articles/s41467-025-64701-7
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Closing 4 wonderful years of PhD in the ParaFrap & EMBO Workshop in a beautiful french island. Thank you
@hakimi.bsky.social
and
@parafrap.bsky.social
for this wonderful learning journey 💕
3 months ago
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I’m excited to share our new preprint! We’ve been investigating a specific domain in TgSNF2L that forms decamers in vitro. Every time we attempted to break them apart, they just snapped back together. That tenacity earned it the nickname Hydra. 🐉 🔗
www.biorxiv.org/content/10.1...
loading . . .
Hydra domain drives SNF2L multimerization and marks ISWI diversification in parasites
ISWI chromatin remodelers are conserved regulators of nucleosome positioning and chromatin accessibility across eukaryotes, yet their evolutionary diversification is poorly understood. In the apicompl...
https://www.biorxiv.org/content/10.1101/2025.09.03.673926v1
5 months ago
0
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1
reposted by
Belen Pachano
Mohamed-Ali HAKIMI
5 months ago
Zeus had his Hydra ⚔️, now Toxoplasma has its own. Meet Hydra: not a monster, but a brand-new protein domain. It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma. Our team and colleagues from
@embl.org
#Grenoble
just dropped the preprint 👉
www.biorxiv.org/content/10.1...
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Thrilled to share our latest review! 🎉 It captures the ideas and discussions that have shaped our work in recent years. Big shoutout to the amazing authors 👏
@hakimi.bsky.social
www.sciencedirect.com/science/arti...
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Decoding the epigenetic blueprint behind Toxoplasma (pre)sexual commitment and chronic persistence
Toxoplasma gondii, a widespread apicomplexan parasite, navigates a complex life cycle in which it switches back and forth between tachyzoites and brad…
https://www.sciencedirect.com/science/article/pii/S1369527425000840
5 months ago
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Thank you for providing me an amazing environment to learn and work. I could not have asked for a better mentor!
add a skeleton here at some point
6 months ago
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Glad to have contributed to this amazing work out now in
@embomolmed.org
! 🎉 Big shoutout to Marie G. Robert & Christopher Swale and
@hakimi.bsky.social
!
www.embopress.org/doi/full/10....
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Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine
imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...
https://www.embopress.org/doi/full/10.1038/s44321-025-00252-0
8 months ago
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reposted by
Belen Pachano
Mohamed-Ali HAKIMI
8 months ago
🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...
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Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine
imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...
https://doi.org/10.1038/s44321-025-00252-0
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reposted by
Belen Pachano
LabEx ParaFrap
9 months ago
An ISWI-related chromatin remodeller regulates stage-specific gene expression in
#Toxoplasma
gondii. By Belen Pachano (ParaFrap PhD student) et al., team
@hakimi.bsky.social
. In
@natmicrobiol.nature.com
www.nature.com/articles/s41...
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An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology
Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...
https://www.nature.com/articles/s41564-025-01980-2
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Open Sesame: The Protein Behind Parasite Stage Switching "To make sense of this genomic jungle, the parasite relies on an extra layer of regulation to ensure precise gene activation at the right time and in the right place"
go.nature.com/3RJNMfb
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Open Sesame: The Protein Behind Parasite Stage Switching
https://go.nature.com/3RJNMfb
10 months ago
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Thrilled to share my first paper, now out in
@natmicrobiol.nature.com
! Huge thanks to my amazing supervisor
@hakimi.bsky.social
and everyone who contributed to this work!
www.nature.com/articles/s41...
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An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology
Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...
https://www.nature.com/articles/s41564-025-01980-2
10 months ago
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reposted by
Belen Pachano
Mohamed-Ali HAKIMI
10 months ago
In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep. A dance of nucleosomes shaping space for life parasite stages to unfold. Now in Nature Microbiology:
rdcu.be/ehkWp
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An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii
Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...
https://rdcu.be/ehkWp
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reposted by
Belen Pachano
Mohamed-Ali HAKIMI
10 months ago
A humorous reflection on the first article from my stellar PhD student, Belen Pachano.
communities.springernature.com/posts/open-s...
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Open Sesame: The Protein Behind Parasite Stage Switching
https://communities.springernature.com/posts/open-sesame-the-protein-behind-parasite-stage-switching
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