Virtual cells for predictive immunotherapy - @fertiglab.bsky.social @genomescience.bsky.social go.nature.com/4jfqM3Y

The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

It's craaazy that chemo has been in the clinic for so long, yet its therapeutic index remains incompletely understood. In this #Perspective, Letai & de The explore existing models + knowledge gaps, & suggest principles for optimizing dosing + scheduling. @natrevcancer.bsky.social bit.ly/3C53w8g

This year, the term “scientist” turns 190 years old! It was coined by William Whewell, who also considered the alternatives: “savant”, “philosopher”, “nature-poker”, and “nature-peeper” Did he choose the right one?

A concise, insightful review of liquid biopsies for cancer www.cell.com/cancer-cell/...

New principles for international genomic collaborations No more helicopter research, no more using and extracting resources without recognition to the local researchers and communities www.who.int/news/item/20...

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

www.nature.com/articles/s41... Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. www.nature.com/articles/d41...

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺 Hope its useful! go.bsky.app/FEoaJMc

A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...