Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

We are looking for a PhD student to study chromatin changes related to heart regeneration, in collaboration with @bakkerslab.bsky.social . Please share and apply! www.hubrecht.eu/nl/vacature/...

ChromSMF preprint is out!🚀 tinyurl.com/ChromSMF We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting! In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬 What does this unlock? ⬇️

My new lab at IGH (Montpellier) is recruiting a postdoc. We develop single-molecule imaging approaches to study RNA–protein dynamics in living cells. Full details & application: euraxess.ec.europa.eu/jobs/417402 Please feel free to share. #biophysics #RNA #microscopy #postdoc

Out now in Cell Systems: We develop a technique to visualize influenza A virus in live cells with single viral RNA resolution. Combined with precise readouts of viral transcription, we map the whole influenza A viral life cycle and identify key bottlenecks in infection. www.cell.com/cell-systems...

Our paper on visualising influenza A virus in live cells with single viral RNA resolution is now out in Cell Systems 🥳 For more details about what we did, see the thread about the preprint below ⬇️

Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/

Are you interested in working on related projects? 🌱 The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position. Apply here: www.hubrecht.eu/jobs

I am excited to announce that I will be moving to IMB Mainz next year! The Winter call for the IPP PhD program is now open; if you are interested in maternal #mRNA regulation and #translation in early vertebrate development, please apply! Deadline: 16 October. More info: www.imb.de/students-pos...

Please pread the word. We have just launched the Hubrecht International PhD Program (HIPP). Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment? Then apply to the HIPP!! 👇

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists shorturl.at/avBBy

### PhD position alert ### Please repost! I'm excited to announce a new *PhD position* within our group. We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs! werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

Congratulations to @bramverhagen.bsky.social who successfully defended his PhD on May 8th! He developed a new tool, called RiboScan, which helped him discover new sequences in the mRNA that contribute to finding the start site of the coding sequence. See: https://www.hubrecht.eu/phd-bram-verhagen/

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Very excited to share a new paper from the lab! We visualize RSV infection with single-vRNP resolution and show how the virus coordinates transcription and replication with the formation of viral factories, biomolecular condensates that act as sites of viral genome control. doi.org/10.1101/2025...

We challenged our researchers to describe their work in 10 words or less. See how they did in this video!