Henry Lee
@citizenlee.bsky.social
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CEO at Cultivarium. Technobiologist, starting with microbes.
So you sequenced a billion+ bases. That donāt impress me much. JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
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9 days ago
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We scientists were so preoccupied with whether we could send samples out for cheap pooled sequencing, we didnāt stop to think if we should.
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22 days ago
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After a few conversations on AI and science this week, I keep coming back to the same point: execution, not ideation, is still the bottleneck. I wrote this up here:
open.substack.com/pub/hhlee/p...
23 days ago
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Scientific progress depends less on what problems we prioritize and more on who is allowed to assemble, and under what conditions.
about 1 month ago
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Henry Lee
Alex Crits-Christoph
3 months ago
Very happy to share our recent work
@cultivarium.bsky.social
on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic. We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
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Stu Cantrill
3 months ago
Nov 7th is the birthday of both Lise Meitner & Marie Curie. Of the 13 chemical elements named directly after real people (not mythological figures) only two are named after women: meitnerium and curium (the latter of which is named in honour of both Marie & her husband)
#chemsky
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Whether you want to industrialize biology or biologize industry, we could use new financing structures. I propose BiBs (Bioindustrial Bucks).
www.genengnews.com/industry-ne...
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Bring on the BioIndustrial Bucks: Growing Americaās Bioeconomy
Synthetic biology is ready for the next developmental milestone and Americaās leadership depends on getting the financing right.
https://www.genengnews.com/industry-news/bring-on-the-bioindustrial-bucks-growing-americas-bioeconomy/
3 months ago
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Henry Lee
Viv Goosens
10 months ago
Register for free (
www.cultivarium.org/portal
) to access their fantastic work and engage with their growing community. Let's diversify our biological models for deeper understanding! (2/2)
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Portal ā Cultivarium
https://www.cultivarium.org/portal
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Henry Lee
Viv Goosens
10 months ago
I'm thrilled to finally share that
@wellcometrust.bsky.social
funding
@cultivarium.bsky.social
to expand their portal an include more
#fungi
&
#archaea
. Already a go-to for bacteria research, as a hub to find info on how to grow and manipulate microbes. (1/2)
blog.cultivarium.org/p/fungi-and-...
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Filaments of the Future
Over the next three years, Cultivarium will weave fungi and archaea into the fabric of a healthier, cleaner, and more resilient world.
https://blog.cultivarium.org/p/fungi-and-archaea
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Henry Lee
Cultivarium
10 months ago
We're gearing up to tackle new kingdoms of life, thanks to generous support from
@wellcometrust.bsky.social
. Get in touch! Read more on our blog:
cultivarium.substack.com/p/fungi-and-...
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Henry Lee
Stacey Burns
11 months ago
I got your waste, fraud, and abuse right here
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Jeremy Berg
11 months ago
Bluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
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Carolyn Bertozzi
about 1 year ago
Cool paper using LLM to discover a protein sequence code for subcellular localization š
www.science.org/doi/10.1126/...
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Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
https://www.science.org/doi/10.1126/science.adq2634
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Sri Kosuri
about 1 year ago
Itās been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). Iām reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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We will continue to improve this resource and would like your feedback!
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about 1 year ago
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Itād be more informative for all if all plasmid identities moved to specific sequence definitions (ie Sequence Object Identifier like DOI) instead of taxonomic and self-important naming schemes (ie using our own initials).
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about 1 year ago
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Henry Lee
Eduardo Rocha
about 1 year ago
New preprint. Large genomes vibriophages have it all: multiple functions, autonomy (full set of tRNA genes!), anti-defenses, broad host range. Yet, they remain rare, pinpointing the limits of generalists. Great collaboration with
@fredoleroux.bsky.social
led by Charles Bernard in our lab.
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Henry Lee
George Takei
about 1 year ago
I continue to be deeply moved by this statement to the heavens by President Carter.
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Yikes, only ~11% of all PubMed-indexed articles are open-access (~4M out of 37M). Guess all those AGI/ASI BioLLMs and All Pipetting self-driving labs (APSDls - coined it here first) will belong to journals orā¦knowledge pirates.
about 1 year ago
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Henry Lee
Patrick Monahan
about 1 year ago
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Important work that should not be forgotten or diminished.
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about 1 year ago
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Itās the best thing out there.
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about 1 year ago
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Henry Lee
Nature Portfolio
about 1 year ago
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships.
https://go.nature.com/49of3Mk
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Weāre making it easier for you to figure out exactly what is and is not possible for your most interesting bacteria.
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about 1 year ago
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Henry Lee
Axel Visel
about 1 year ago
BOOSTER, a newly identified orphan gene, supercharges photosynthesis and, when overexpressed, boosts height of poplars by up to 200% (at least in greenhouse) To make it even more interesting, part of the gene seems derived from a poplar fungus-farming ant š Paper:
www.cell.com/developmenta...
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Are there any large scale efforts to use pregnancy brain for connectomics and/or remodeling with hormonal programming?
about 1 year ago
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Whatās the best way to pellet cells in deep 96-well plates WITHOUT a giant 3k rcf centrifuge? Mega bonus points if you donāt have to spin⦠cc
@atinygreencell.bsky.social
about 1 year ago
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Anthony Amend
about 1 year ago
RP PLS! Iʻm hiring 3 postdocs at U Hawaiʻi to study yeast diversity and evolution, marine fungi, and the genomics of microbiomes in experimental foodwebs. All of these projects have existing datasets and LATITUDE to pursue individual interests and "blue sky" ideas
www.dropbox.com/scl/fi/5d7u4...
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Canāt wait to read this
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about 1 year ago
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Why did sheaths need to arise? š¤
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about 1 year ago
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Unfortunate, but we need to know.
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about 1 year ago
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about 1 year ago
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One must also consider that all DNA-based life forms are already other beingās dank memes.
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about 1 year ago
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Wake up baby, the 1000 page manifesto on naming fungi just dropped, 2024 edition.
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about 1 year ago
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Looking forward to learning the latest on this!
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about 1 year ago
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Growth is so incredible!
about 1 year ago
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I didnāt open this PDF so what if this preprint is also a hoax?
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about 1 year ago
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Asking for a friend.
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about 1 year ago
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So are we going to discuss abolishing the NIH here or is that type of content strictly for the other platform?
about 1 year ago
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Fun! Intriguing that transposons are not depleted in plants. When will someone use plants as a bacterial genome minimization tool?
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about 1 year ago
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Itās time to map the holobiomes
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about 1 year ago
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Henry Lee
christoph_STCmicrobeblog
about 1 year ago
tagging
#PhageSky
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Normalize the drugs
over 1 year ago
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you reached the end!!
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