👇👇👇 New preprint dropped! Where we dive deep into the factors that restrict pluripotent stem cells to make the RIGHT cell types in the RIGHT place in planarians. Many surprises in this very exciting story. @kuangtse.bsky.social

New preprint alert! 🚨 Check out this awesome highlight thread by @kuangtse.bsky.social -- How does a pluripotent stem cell differentiate into the correct cell type at the right location? 🧐

Full spectrum of ‘zebrabow’ embryos. Credit to @jhenninger.bsky.social. #ZebrafishZunday 🧪

It’s time for another #FluorescenceFriday! 👩‍🎨🎨🔬🫀multi-color labeled zebrafish heart with mosaic expression of diverse myl7:color plasmids 🏳️‍🌈🌈

Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...

Identification and developmental profiling of microRNAs in the acoel worm Hofstenia miamia https://www.biorxiv.org/content/10.1101/2024.12.01.626237v1

Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵

Welcome to the #devbiolwriteclub Bluesky Boot Camp! I’ll be posting here regularly with thoughts and exercises to help scientists become better writers. Let’s start by managing expectations: I will NOT help you write better. I WILL help you become a better writer. 🧵 1/10

During thanksgiving, I sometimes wish that I was a slingjaw wrasse. They can extend their jaws 1/3 of their entire body length. Perfect for getting seconds without standing up. We printed one today from a specimen we collected in Okinawa

I’m delighted to share that I will be starting my lab @univmiami.bsky.social in Spring 2025! We will study cellular and developmental biology in non-bilaterian animals – cnidarians, ctenophores, placozoans, and sponges – to explore early animal evolution.

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

(1) How can we build complex structures from a limited set of progenitors and cell types? In our new preprint, we describe patterns of cell fate decisions during early development and (in some cases) identify molecular correlates of different behaviors. www.biorxiv.org/content/10.1...

(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why

#NewPI achievement unlocked: the first #obrownlab publication is officially accepted (🍾) about #zebrafish #glia (green) and the vasculature (magenta). Thanks to our reviewers and congrats to all of the lab members! What a great 1st paper experience. Happy #fluorescencefriday ya'll!

Another go-to graph for "AHA!" moments: phylogenetic trees. This @embl.org hosted interactive tree viz tool is intuitive and so so so customizable.

I heard that today is #Caturday 🐱

"Dark TFs": new manuscript mapped 166 uncharacterized human transcription factors, finding half bind genomic "dark matter," often closed chromatin rich in transposable elements. www.biorxiv.org/content/10.1...

In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...

Calcein staining showing the skeleton on the aboral side of a juvenile sea star (Patiria miniata) Everything looks better with a rainbow LUT 🌈😊 #microscopy #echinoderms #fluorescence

"A picture contains 1,000 projects." Acrobeles roundworm head, photo by Kaiden Power @wormkaiden.bsky.social How many open questions about ECM patterning can you find in these pictures?

7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

Cell division is NOT a must for differentiation during early zebrafish embryogenesis. www.nature.com/articles/s41...

For not quite #FluorescenceFriday, here are pluteus larvae of sea urchin under polarized light 👾🚀

#FluorescentFriday #Zebrafish Visualization of neutrophil migration kinetics after tailfin wound at a whole animal scale. We need more research done at a whole-animal scale... so much we don't ask because we're just looking at the small local wound under the 🔬

Excited to share work that @ceriweber.bsky.social started and drove in my lab. Tails!! We know a lot about limb bone growth, but vertebrae have completely different embryonic and evolutionary origins. What controls growth and proportion in the vertebral skeleton? www.biorxiv.org/content/10.1...

Baby flounder have an eye on each side, BUT as the flounder grows the eye 'wanders'. First creeping up slowly, then cresting the skull as a living eyeball hat. From there it tumbles to the other side, reshaping bone & muscle, & the fish goes flat 📸Jonathan Jarrell www.facebook.com/groups/26060...

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

Thrilled to share: out in @natureportfolio.bsky.social (!) just in time for Thanksgiving, the dinosaurian history of how your turkey does the twist. Fibular reduction enabled mid-drumstick mobility, unlocking extreme knee long-axis rotation in theropods 🍗🦖🧵 www.nature.com/articles/s41586-024-08251-w

Please read and share this ⬇️ journals.biologists.com/dev/article/...

Enjoy some Bluesky positive vibes (sound on👍) from these juvenile Lake Sturgeon @garlab.bsky.social!

Our latest work is out!! Short thread below. www.cell.com/developmenta...

Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact. A must read for PhD students: Problem choice and decision trees in science and engineering. pubmed.ncbi.nlm.nih.gov/38608651/

Shamelessly taking advantage of the bluesky migration to share again some of my favorite echinoderm pics 😀🤩 🔽 Acetylated tubulin (nerves and cilia) and phalloidin (muscles) stains in a juvenile sea urchin (Paracentrotus lividus) just after metamorphosis ⭐

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks! 📽️ youtu.be/avrmIs3vPUQ?...

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases https://www.biorxiv.org/content/10.1101/2024.11.15.623687v1

I make pottery pieces, often dishes, of animals I love. This is the nudibranch Hypselodoris confetti. It is one of the largest pieces I made so far (about 13 inches / 35 cm long). Reference photo by Alex Mustard #handbuiltpottery #ceramicart #SciArt #invertebrates #Nudivember #nudibranchs

*Highly recommend* a simple plug in called Color Oracle: colororacle.org It’s a free color blindness simulator. Just one click, it shows you in real time what people with common color vision impairments will see on your screen. I use it to doublecheck everything! #microscopy #figures #academicsky

So happy to see this picture of the nervous system in a transparent Henricia sea star selected as an image of distinction by @NikonSmallWorld !! 😎 It was imaged using the see-star clearing protocol developped with @Nat Clarke ⬇️Check the paper here: link.springer.com/article/10.1...

SOX and POU are crucial Transcription Factors in animal development, believed to be innovations of this group. Here we find them in unicellular relatives of animals. And hold tight, you can use a choanoflagellate 🦠 SOX gene to make a full chimeric 🐁 ! Read more here 🧵: rdcu.be/d0dPN 1/6