How do tissues organise, adapt, or collapse? 🧬 We’re looking for a postdoc with strong quantitative skills to tackle these questions in a highly interdisciplinary project bridging spatial omics, ecology & mathematical modelling (expertise required in at least one topic). Apply 👉 tinyurl.com/3d37d3st

Come do some cool cell cycle science with the awesome @alexisbarr.bsky.social and me! 🔬✨ We’re looking for an enthusiastic computational biologist / data scientist (4-year postdoc) to dive into loads of cancer genomics & transcriptomics data. Details below. Please share!

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

Feeling very fortunate to be awarded a Programme Foundation Award from CRUK @cruk-si.bsky.social This is a new area for the lab & lets us team up with @mariasecrier.bsky.social to tackle a big problem of how different cancers lose control of proliferation

Bu hafta “Yapay Zekanın Politik Ekonomisi” etkinliğinde Altuğ Yalçıntaş hocamız “büyük veri” meselesini iktisadi ve siyasal boyutlarıyla ele alırken, aynı saatlerde Cenk Çelik hocamız Tek Hücre ve Uzamsal Boyutta Canlılık” atölyesinde “hücreler arası iletişim konusunu masaya yatırıyordu.

We recently published a review reflecting on challenges and opportunities in characterising cancer cell states and niches using spatial transcriptomics and integration with digital pathology, see full thread below. Thank you Molecular Oncology for the opportunity!

📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!

Bilimler Köyü'nde gelecek hafta... 📍 Detaylı bilgi ve başvuru: bilimler.org/etkinlikler/ #bilimlerköyü #villageofsciences

We, Secrier Lab UCL @ugiatucl.bsky.social Genetics Institute, discussed challenges in cell state identification using spatial transcriptomics in cancer research, now out in Molecular Oncology. 
doi.org/10.1002/1878...
#SpatialTranscriptomics #CancerResearch #SpatialNiches

New preprint from the Secrier lab. @cenkcelik.bsky.social @mariasecrier.bsky.social present EnrichMap, a Python package to compute gene set enrichment scores in spatial transcriptomics data: tinyurl.com/yc48f4fx. See an explainer thread from @cenkcelik.bsky.social here: bsky.app/profile/cenk....

Want to uncover biologically meaningful patterns in spatial omics data? Check out our new method EnrichMap, details below. Work led by the brilliant @cenkcelik.bsky.social! #spatialomics #genesets

[Preprint alert] We’re thrilled to introduce EnrichMap: a powerful new method for spatial gene set enrichment. It’s spatially aware, biologically meaningful and built for the next generation of spatial transcriptomics. www.biorxiv.org/content/10.1...

Işık yalnızca çevremizi aydınlatmaz; aynı zamanda doğanın en temel sırlarını da içinde taşır. Bu etkinlikte, Cambridge Üniversitesi’nden Prof. Mete Atatüre ve Dr. Yusuf Karlı’nın yürütücülüğünde, ışığın klasik fiziğin ötesine geçen dünyasına adım atacağız. ++

Yaşamı tek bir hücrenin sınırlarından başlayarak uzamsal boyutlara taşıyoruz. Bu etknlikte, hücresel düzeyde bilginin nasıl aktarıldığını, düzenlendiğini ve farklı mekânsal ölçeklerde nasıl organize olduğunu birlikte inceleyeceğiz.++

Check out how 💪🏼Enterococci💪🏼 use lactic acid to suppress the inflammatory response and promote virulence. Project started by Brenda Tien during her PhD and brought home by the always excellent @ronni.bsky.social! 🥳

Balancing tumour proliferation and sustained cell cycle arrest through proteostasis remodelling drives immune niche compartmentalisation in breast cancer https://www.biorxiv.org/content/10.1101/2025.01.08.632014v1

New insights into the role of p21 in lung cancer from the fantastic @alexisbarr.bsky.social!

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇 biorxiv.org/content/10.1101/2024.12.11.627935v1