Rafael Peña-Miller
@penamiller.bsky.social
📤 681
📥 374
📝 3
Scientist working somewhere around mathematical, computational and experimental microbiology
reposted by
Rafael Peña-Miller
Alvaro San Millan
2 months ago
New paper with my (amazing) friend and mentor
@jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!! With
@asantoslopez.bsky.social
@wfigueroac3.bsky.social
Akshay Sabins and others
www.cell.com/cell-reports...
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Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01227-6
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Rafael Peña-Miller
Jerónimo Rodríguez-Beltrán
5 months ago
Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬? In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments! 👇 Check out all the details in Paula’s thread! Hint: 🐇 (most of the time)
add a skeleton here at some point
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reposted by
Rafael Peña-Miller
Paula Ramiro-Martínez
5 months ago
New paper alert! 🚨 Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate. We combine theory, simulations, experimental evolution, and bioinformatics to demonstrate that mutation rates scale with plasmid copy number. Let's dive in! 🧵👇
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Plasmids promote bacterial evolution through a copy number-driven increase in mutation rate
Plasmids are autonomously replicating DNA molecules that stably coexist with chromosomes in bacterial cells. These genetic elements drive horizontal gene transfer and play a fundamental role in bacter...
https://www.biorxiv.org/content/10.1101/2025.07.21.665944v1.article-metrics
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reposted by
Rafael Peña-Miller
Jerónimo Rodríguez-Beltrán
6 months ago
🚨🚨New paper out in
@natcomms.nature.com
!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉
www.nature.com/articles/s41...
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Universal rules govern plasmid copy number - Nature Communications
Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...
https://www.nature.com/articles/s41467-025-61202-5
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New preprint led by
@brunoluviano.bsky.social
& Fernando Santos. We show that filamentation enhances bacterial survival under toxic stress — not as collateral damage, but as a regulated morphological response. TL;DR: Filamentation isn’t a symptom, it’s a strategy!
www.biorxiv.org/content/10.1...
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8 months ago
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Rafael Peña-Miller
Jose A Escudero
8 months ago
🧪 Finally out after peer review, our work showing that "Mobile
#Integrons
carry Phage Defense Systems" is now published in Science 🎉 Short 🧵
www.science.org/doi/10.1126/...
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Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
https://www.science.org/doi/10.1126/science.ads0915
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reposted by
Rafael Peña-Miller
Macarena Toll-Riera
10 months ago
We are recruiting! We are looking for a PhD student to study rapid adaptation to stress in bacteria (
shorturl.at/sr0Mj
). Come join us in Barcelona!
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reposted by
Rafael Peña-Miller
Alfonso Santos Lopez
about 1 year ago
Check out this amazing Spotlight on our recently published paper ->
www.cell.com/trends/micro...
Huge thanks to
@oliviakosterlitz.bsky.social
, Benjamin Kerr and Elisabeth Duan for this great spolight.
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Our paper on plasmid-driven heterogeneity is finally out!
www.nature.com/articles/s41...
@sanmillan.bsky.social
@ayari.bsky.social
@jerorb.bsky.social
@craigmaclean.bsky.social
almost 2 years ago
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reposted by
Rafael Peña-Miller
Sur Herrera Paredes
almost 2 years ago
Thanks Thanks to
@ayari.bsky.social
for inviting me to present at
@meehubs.bsky.social
from the Cuernavaca hub. Got some great questions from the audience in other parts of the World!
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reposted by
Rafael Peña-Miller
MEEhubs
almost 2 years ago
Only a bit more than 12 hours till start of
#MEEhubs2024
. We have hundreds of registered participants, some shared their location and where they travel to on the map below!
#MicroSky
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reposted by
Rafael Peña-Miller
Alvaro San Millan
about 2 years ago
Can we predict AMR evolution?? We sure can try! New study published today in PNAS
www.pnas.org/doi/10.1073/...
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