Daniela Senft
@daniela-senft.bsky.social
📤 892
📥 566
📝 4
Associate Editor at Nature Reviews Cancer. I´m interestaed in all aspects of cancer research.
reposted by
Daniela Senft
Nature Reviews Cancer
about 1 month ago
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N6-Methyladenosine: an RNA modification as a central regulator of cancer
Nature Reviews Cancer, Published online: 08 December 2025; doi:10.1038/s41568-025-00889-6In this Review Luo, Kharas and Jaffrey outline how N6-methyladenosine (m6A) RNA modification affects RNA stability, translation, splicing and immune responses to influence cancer biology. They discuss emerging evidence on how m6A may influence cancer metabolic reprogramming and outline the challenges and opportunities of targeting m6A writers, erasers and readers for cancer therapy.
https://www.nature.com/articles/s41568-025-00889-6?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
about 1 month ago
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Targeting phagocytosis checkpoints for cancer immunotherapy
Nature Reviews Cancer, Published online: 08 December 2025; doi:10.1038/s41568-025-00893-wMacrophages can eliminate cancer cells through phagocytosis, which is tightly regulated through inhibition and activation of various phagocytic receptors. In this Review, Veillette and colleagues outline how targeting these phagocytic checkpoints could be harnessed therapeutically, address therapeutic efficacy concerns, and propose strategies to enhance therapeutic outcomes in future clinical applications.
https://www.nature.com/articles/s41568-025-00893-w?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
about 1 month ago
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Being in the zone
Nature Reviews Cancer, Published online: 09 December 2025; doi:10.1038/s41568-025-00899-4A study published in Science shows that liver zonation shapes hepatocellular carcinoma (HCC) development. In mice, HCC predominantly originates from zone 3 hepatocytes, where GSTM2 and GSTM3 drive initiation by inhibiting ferroptosis, revealing metabolic vulnerabilities in liver cancer.
https://www.nature.com/articles/s41568-025-00899-4?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
3 months ago
Our November issue is online! 🧣 🍂 ☕ It's pt. 2 of our Focus issue on #AgeingandCancer and features articles on: - The genetics & epigenetics of the ageing TME - Ageing, immune fitness & cancer - The evolution of cancer & ageing Check it out 👇
http://bit.ly/4oUyzq...
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reposted by
Daniela Senft
Nature Reviews Cancer
4 months ago
Check out our focused collection of articles highlighting research on ageing and cancer to better cancer prevention, diagnostics and therapy.
www.nature.com/collections/...
It features
#Comments
#Reviews
#Perspectives
from leaders in the field: a 🧵
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Ageing and Cancer
Ageing is a fundamental driver of cancer, fostering the accumulation of genetic and epigenetic changes that disrupt cellular homeostasis, promote immune ...
https://www.nature.com/collections/afcjeefdid
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How does ageing affect cancer? Read all about it in our latest Focus isse ⬇️
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4 months ago
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reposted by
Daniela Senft
Nature Reviews Cancer
4 months ago
As part of our Series on
#SexDifferences
in cancer, Yingsheng Zhang & Xue Li wrote a Comment article that outlines the impact of
#sex
on
#metastasis
. Check it out ⬇️
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The impact of sex on metastasis - Nature Reviews Cancer
Sex matters in metastasis, but it has received little attention in research. Here, we highlight the emerging and important roles of biological sex in metastasis and advocate for mechanistic and quantitative studies for the future development of sex-tailored therapies.
https://bit.ly/4mWzgyO?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
4 months ago
Review🚨 Karschnia, Nelson & Dietrich outline what is currently known about the mechanisms that underlie the clinical symptoms of cancer therapy-related central nervous system injury and peripheral neuropathy 📖👇
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Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity - Nature Reviews Cancer
Neurotoxicity impacting the central and peripheral nervous systems is a considerable adverse effect of both conventional and novel cancer therapies. In this Review, Karschnia et al. outline what is currently known about the mechanisms that underlie the clinical symptoms of central nervous system injury and peripheral neuropathy and the ongoing development of interventions to treat and prevent this unmet medical need.
https://bit.ly/3VNzhZK?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
4 months ago
Our SEPTEMBER issue is live! 🌤️🍂🌻🍂 It features articles on: - ER stress responses in anti-cancer immunity - Regulatory T cells in the TME - Metabolic adaptations of brain metastasis - Engineering strategies for nanoparticles Read it now👇
bit.ly/4mW1JnQ
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reposted by
Daniela Senft
Magdalena Skipper
7 months ago
From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal. We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers 🧪
#AcademicSky
www.nature.com/articles/d41...
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Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
https://www.nature.com/articles/d41586-025-01880-9
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reposted by
Daniela Senft
Nature Reviews Cancer
8 months ago
🚨 PERSEPCTIVE 🚨 Here Joshua Rubin emphasizes the challenges, opportunities and importance of integrating gender-sex interaction differences into cancer biology & clinical parameters to enhance precision medicine. @uwsom-wwami.bsky.social 👇 📖 for more details
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Gender and sex interactions are intrinsic components of cancer phenotypes - Nature Reviews Cancer
In this Perspective, Joshua Rubin emphasizes the importance of gender–sex interaction (GSI) differences in cancer biology and clinical parameters to enhance precision medicine. He outlines the challenges and opportunities of integrating GSI effects into personalized oncology and argues that optimal outcomes require extending our current molecular approaches to include family history, life history and individual vulnerabilities in our diverse groups of patients with cancer.
https://bit.ly/3HoO74Y?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
10 months ago
Jordan Lee describes the Tumor Molecular Pathology (TMP) machine learning toolkit that can classify new samples into previously defined #TCGA molecular subtypes
@ohsunews.bsky.social
#TCGA
👀 ⬇️
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#ToolsoftheTrade 🚨
https://bit.ly/4iEi2n5?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
10 months ago
At the
#KSTumorMetab25
meeting? Check out the latest review by Ayelet Erez & colleagues for more details on how metabolic interplay between the tumour & the host shape the tumour macroenvironment. 👀⬇️
bit.ly/3ReWTEo
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Metabolic interplays between the tumour and the host shape the tumour macroenvironment - Nature Reviews Cancer
In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explo...
https://bit.ly/3ReWTEo
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reposted by
Daniela Senft
Nature Reviews Cancer
10 months ago
Velculescu & Team review targeted and genome-wide
#cfDNA
detection approaches and discuss their potential to complement existing screening programs or enhance early cancer detection for those cancers without effective screening methods.
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#REVIEW🚨
https://bit.ly/3QZe3pn?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
10 months ago
#ResearchHighlight 🚨 @claballabio.bsky.social from Leanne Li group
@crick.ac.uk
#ResearchHighlight
show that
#neuroendocrine
#SCLC
cells exhibit electrical activity that drives tumour progression. They rely on OXPHOS to meet the high energy demand of these electrophysiological processes. 👀⬇️
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Review
https://bit.ly/41BN4VP?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Neurology
10 months ago
To mark
#InternationalWomensDay
tomorrow, the
#NatureReviews
Collection on women's health has been updated. Click below to read articles on various aspects of women's health, including brand new Reviews from
@natrevcardiol.bsky.social
and
@natrevgastrohep.bsky.social
go.nature.com/30kDWG3
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Women’s health
Research into women’s health has suffered from historical neglect and lack of funding.
https://go.nature.com/30kDWG3
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reposted by
Daniela Senft
Nature Reviews Cancer
10 months ago
In this Expert Recommendation,
@drholowatyj.bsky.social
&Co cover the current state of the field in #AppendicealCancer and propose a conceptual research framework to advance knowledge of this rare cancer to deliver better outcomes for patients. #RareDiseaseDay
@acpmpresearch.bsky.social
#AppendicealCancer
#RareDiseaseDay
📖 ⬇️
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#REVIEW🚨
https://bit.ly/4gQz7Jn?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
Triantafyllos Stylianopoulos, Rakesh K. Jain & Co review the utility of continuous models & discrete models in therapy delivery and efficacy in cancer and propose ways to integrate mechanistic and AI-based models to improve patient outcomes. 📖 👇 bit.ly/3X7JGAu
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Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer - Nature Reviews Cancer
https://www.nature.com/articles/s41568-025-00796-w?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
#REVIEW 🚨 Genetic predisposition is the major known cause of cancer in children. In our Feb issue, Kratz highlights the genetic architecture of it, focusing on its roles in cancer prediction, prevention, surveillance and therapy. 📖 👇
https://bit.ly/3ZHhZ...
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Re-envisioning genetic predisposition to childhood and adolescent cancers - Nature Reviews Cancer
Genetic predisposition is the major known cause of cancer in children and adolescents. In this Review, Kratz highlights the genetic architecture of cancer in children and adolescents, examining cancer predisposition syndromes, cancer predisposition genes, embryonic mosaicism and polygenic risk...
https://bit.ly/3ZHhZAA?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
# REVIEW 🚨 Simovic-Lorenz & Ernst from
@dkfz.bsky.social
discuss mechanisms of
#chromothripsis
, its impact on cancer and vulnerabilities of chromothriptic tumours. 📖 ⬇️
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Chromothripsis in cancer - Nature Reviews Cancer
https://go.nature.com/4eyP71i?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
Beyond prostate cancer: Androgen receptor signaling plays a key role in multiple malignancies. Dotto & collegues explore AR’s context-dependent functions in cancer cells & the TME, and highlight AR-targeting cancer trials. 📖 👇
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Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities - Nature Reviews Cancer
https://go.nature.com/4ig9hR0?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
FINALLY 🥁...our top most downloaded article of the year is…. 🥁🥁🥁 Why do patients with cancer die? By @tcox.bsky.social, Erik Sahai, et al.
https://bit.ly/3WIyl...
#metastasis #cancertherapy #cancermodels
@crick.ac.uk
#metastasis
#cancertherapy
#cancermodels
atureportfolio.bsky.social
#NRCtop10of2024
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Why do patients with cancer die? - Nature Reviews Cancer
In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a....
https://bit.ly/3WIylHb?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 2nd most downloaded article in 2024: Cancer therapy with antibodies by Paul, Gabelli, Ho, van Elsas et al.
https://bit.ly/3EjrG...
#drugdevelopment
#cancertherapy
#antibodytherapy
@natureportfolio.bsky.social
#NRCtop10of2024
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Cancer therapy with antibodies - Nature Reviews Cancer
In this Review, Paul et al. provide an overview of therapeutic antibodies as an important modality in cancer therapy today. They summarize the different approaches used by antibodies to target cancer cells including those of immune checkpoint inhibitors, bispecific antibodies...
https://bit.ly/3EjrGgh?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 4th most downloaded article in 2024: Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues
https://bit.ly/42Cvr...
@rockefelleruniv.bsky.social
@hhmi.bsky.social
@natureportfolio.bsky.social
#NRCtop10of2024
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Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer
In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic factors induce the epigenetic changes necessary for tumorigenesis.
https://bit.ly/42Cvrrk?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 3rd most downloaded article in 2024: A guide to artificial intelligence for cancer researchers by @jnkt.bsky.social and colleagues
https://bit.ly/3yEzl...
#AI
#artificialintelligence
#cancermodelling
@natureportfolio.bsky.social
#NRCtop10of2024
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A guide to artificial intelligence for cancer researchers - Nature Reviews Cancer
This Review provides an introductory guide to artificial intelligence (AI)-based tools for non-computational cancer researchers. Here, Perez-Lopez et al. outline the general principles of AI for image analysis, natural language processing and drug discovery...
https://bit.ly/3yEzl64?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
Miriam Merad & Co @sinaiimmuno.bsky.social outline the molecular basis of
#DendriticCell
maturation and the mechanisms through which cancer impairs
#DC
maturation and consider the potential for DC-focused cancer
#immunotherapeutics
. 📖 ⬇️
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#REVIEW 🚨
https://bit.ly/3Q8XSWb?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
#RESEARCHHIGHLIGHT Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, in @cp-cancercell.bsky.social, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin. Read the highlight here 👇
https://bit.ly/4jL8W...
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Allies in the epidermis - Nature Reviews Cancer
Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin.
https://bit.ly/4jL8W9p?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
#COMMENT 🐶 🐱 Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz & Atherton highlight successes and emphasize the need for broader application to improve human cancer treatments. 📖 👇
https://bit.ly/414hi...
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Maximizing the dual benefit of pet dogs in cancer trials - Nature Reviews Cancer
Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes, emphasizing the need for broader application of findings from canine studies to improve human cancer treatments.
https://bit.ly/414hiC1?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 5th most downloaded article in 2024: Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment by Calvin Kuo, Polk & Elisa Zhang
https://bit.ly/4jAOu...
@stanfordpress.bsky.social
@stanfordmedicine.bsky.social
@natureportfolio.bsky.social
#NRCtop10of2024
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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment - Nature Reviews Cancer
In this Review, Polak, Zhang and Kuo discuss the currently available and rapidly evolving 3D tumour organoid models that capture the tumour immune microenvironment. They highlight opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.
https://bit.ly/4jAOuZ1?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 6th most downloaded article in 2024: The evolutionary theory of cancer: challenges and potential solutions by @lucielaplane.bsky.social & @cmaley.bsky.social
https://bit.ly/3PWjS...
#cancermodels #evolutionarybiology
@sorbonne-universite.fr
#cancermodels
#evolutionarybiology
natureportfolio.bsky.social
#NRCtop10of2024
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The evolutionary theory of cancer: challenges and potential solutions - Nature Reviews Cancer
Clonal evolution is now a central theoretical framework in cancer research. In this Perspective, Laplane and Maley identify challenges to that theory such that some non-evolutionary phenomena in cancer cannot be captured by the theory.
https://bit.ly/3PWjSmW?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 7th most downloaded article in 2024: Cancer drug-tolerant persister cells: from biological questions to clinical opportunities by Bardelli, Russo et. al
https://bit.ly/3CkSE...
#persistercells
#DTPs
#cancerresistance
@natureportfolio.bsky.social
#NRCtop10of2024
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Cancer drug-tolerant persister cells: from biological questions to clinical opportunities - Nature Reviews Cancer
Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant persister cells providing paths to advance our understanding of their biology with innovative technologies...
https://bit.ly/3CkSEUb?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 8th most downloaded article in 2024: Exploiting temporal aspects of cancer immunotherapy by Lesterhuis et al.
https://bit.ly/3Xs8l...
#immunotherapy @natureportfolio.bsky.social
#NRCtop10of2024
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Exploiting temporal aspects of cancer immunotherapy - Nature Reviews Cancer
The tumour immune microenvironment greatly affects responses to immune checkpoint therapies. In this Perspective, Zemek et al. explore the dynamic changes in response to both immunotherapy and conventional treatment and advocate for strategic combination therapies over time....
https://bit.ly/3Xs8lRB?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 Our 9th most downloaded article in 2024: Tertiary lymphoid structures in anticancer immunity by Dieu-Nosjean et al.
https://bit.ly/3WGcv...
#cancermicroenvironment
@inserm.fr @natureportfolio.bsky.social
#NRCtop10of2024
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Tertiary lymphoid structures in anticancer immunity - Nature Reviews Cancer
Transient ectopic lymphoid structures known as tertiary lymphoid structures (TLS) have been observed in many solid tumour types. Teillaud et al. discuss how these TLS potentially orchestrate immune responses against tumours locally...
https://bit.ly/3WGcvEc?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
11 months ago
🥳 First up in #NRCtop10of2024: Emerging strategies to investigate the biology of early cancer by Zhou, Tang & Wang
https://bit.ly/4hE1x...
#cancerimaging
#cancerscreening
#cancerprevention
@natureportfolio.bsky.social
#NRCtop10of2024
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Emerging strategies to investigate the biology of early cancer - Nature Reviews Cancer
Understanding the early steps of cancer development is crucial for cancer prevention. In this Review, the authors summarize the advantages and limitations of clinical samples, autochthonous mouse models and organoid models, alongside advanced techniques such as direct imaging, lineage tracing...
https://bit.ly/4hE1xHm?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Nature Reviews Cancer
12 months ago
#REVIEW Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies. 📖 👉
https://bit.ly/40PCQ...
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Epigenomic heterogeneity as a source of tumour evolution - Nature Reviews Cancer
Single-cell epigenomic technologies are refining our understanding of cancer evolution.
https://bit.ly/40PCQ5h?utm_source=dlvr.it&utm_medium=bluesky
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reposted by
Daniela Senft
Katrina Ray
12 months ago
Welcoming the newest members of the
#NatureReviews
family
@natrevbiodiv.bsky.social
&
@natrevcleantech.bsky.social
on their launch week! You can follow them and more Reviews journals (and a few Editors) in this starter pack 🧪
go.bsky.app/KcxvQLp
add a skeleton here at some point
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reposted by
Daniela Senft
Nature Reviews Cancer
12 months ago
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Decoding the functional impact of the cancer genome through protein–protein interactions
Nature Reviews Cancer, Published online: 14 January 2025; doi:10.1038/s41568-024-00784-6Genomic mutations can be translated into modified functional proteins, impacting protein–protein interactions (PPIs) and thus altering cellular functions. In this…
https://go.nature.com/40fIX1d
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reposted by
Daniela Senft
Gabrielle Brewer
12 months ago
Check out our latest Research Highlight by
@daniela-senft.bsky.social
! 👀👇
add a skeleton here at some point
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reposted by
Daniela Senft
Nature Reviews Cancer
12 months ago
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Fructose takes a detour to feed cancer
Nature Reviews Cancer, Published online: 08 January 2025; doi:10.1038/s41568-024-00789-1The mechanisms by which dietary fructose promotes tumour progression have remained poorly understood. A recent study published in Nature reveals that dietary fructose…
https://go.nature.com/4aezNq1
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reposted by
Daniela Senft
Elaine Fuchs Lab
about 1 year ago
Cancers may arise in tissues with a low mutational burden. It’s up to the microenvironment! We discussed this in
@natrevcancer.bsky.social
www.nature.com/articles/s41...
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Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer
In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic ...
https://www.nature.com/articles/s41568-023-00660-9
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reposted by
Daniela Senft
Nature Reviews Cancer
about 1 year ago
We're finally here 👇
add a skeleton here at some point
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reposted by
Daniela Senft
Nature Reviews Cancer
about 1 year ago
Our January issue is LIVE! Perfect Xmas reading! 🎁🎅It features articles on: - Epigenomic heterogeneity as a source of
#tumour
evolution - CSCs and immune evasion - Convergent inducers & effectors of T cell paralysis in the TME - The
#Cancer
DepMap
go.nature.com/41P09Nk
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Looking for weekend reading material? Check out this Review by Anthony Letai and Hugues de The on the critical role of conventional chemotherapy in cancer treatment and the knowledge gaps that persist.
www.nature.com/articles/s41...
@danafarber.bsky.social
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Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer
Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...
https://www.nature.com/articles/s41568-024-00778-4
about 1 year ago
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Don‘t miss this Review from Alana Welm & Co out in
@natrevcancer.bsky.social
discussing the importance of
#PDX
models for functional precision oncology
www.nature.com/articles/s41...
@huntsmancancer.bsky.social
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PDX models for functional precision oncology and discovery science - Nature Reviews Cancer
Patient-derived xenograft (PDX) models are valuable surrogates for drug testing in precision oncology. In this Review, Welm and colleagues outline the opportunities and challenges of PDX models, discu...
https://www.nature.com/articles/s41568-024-00779-3
about 1 year ago
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reposted by
Daniela Senft
Gabrielle Brewer
about 1 year ago
@natrevcancer.bsky.social
#ResearchHighlight
🚨
@daniela-senft.bsky.social
highlights a study showing that lactate derived from glioblastoma stem cells, microglia & macrophages drives histone lactylation, activating immunosuppressive transcriptional programs & upregulating CD47. 👇
bit.ly/49qYzTu
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Lactate gives a sour taste - Nature Reviews Cancer
Wang et al. demonstrate that lactate derived from glioblastoma stem cells, microglia and macrophages drives histone lactylation, activating immunosuppressive transcriptional programs and upregulating ...
https://bit.ly/49qYzTu
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reposted by
Daniela Senft
Anna Dart
about 1 year ago
#NatureReviewsCancer
December issue is LIVE! 🚨🎄❄️ It features Reviews on: - Cancer induced pre-conditioning of distant organs, - Strategies to investigate the biology of early cancer, - Precursor multiple myeloma - & a
#Roadmap
on mRNA splicing in the clinic
bit.ly/4i3cnaG
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