Another example of how mRNA vaccine technology is revolutionizing medicine in real time. Individualized mRNA vaccination triggered robust anti-tumor T cell responses in triple negative breast cancer leading to durable cancer remission. www.nature.com/articles/s41...

some of you are looksmaxxing when you need to be booksmaxxing

In people age 50+, the Covid booster halved hospitalization and deaths. Waning of benefit after 3-6 months For the mRNA BA.1 booster vs no shot after initial vaccination www.sciencedirect.com/science/arti...

Whenever I am he ID consults, we occasionally get paged for a suspected "Zebra". 99% of the time it is not a "Zebra". Just a regular "Horse" that could have been solved by a good history, physical examination and chart review. ID docs are not wizards we simply talk to patients and are thorough :)

Don't get me wrong, I LOVE being a physician. No other career I would choose. But in the past 48 hours, friends/family have called/texted me about: - "I had sepsis!" (they did not) - seizure in the gym - multiple children with febrile illness overseas - anaphylaxis Do I charge them coffee? 😅

Coffee and improved cognition, reduced dementia >130,000 people followed 37 years Benefit seen only with caffeinated coffee or tea and most pronounced ~2 cups/day @jama.com ☕️☕️https://jamanetwork.com/journals/jama/fullarticle/2844764

The South Carolina measles outbreak has triggered rare but serious brain swelling in some children

No #HBV reactivation/incident infxn in PLH w isolated anti-HBc after switching to CAB/RPV #HIV #IDSky #MedSky academic.oup.com/cid/advance-...

Holy moly this chart: Cumulative US measles cases

Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis in the USA? The answer is yes! doi.org/10.1001/jama...

🦠 Flu cases in the US have surpassed the last 5 flu seasons 🏥 Flu-related hospitalizations are rising rapidly 👶 The 2024-25 flu season was the deadliest on record for children Stay informed on #flu, #measles, and emerging outbreaks in our weekly #TrackingReport ⬇️ mailchi.mp/messages/pan...

🧵 Emerging viruses need antivirals. This new Lassa study is encouraging. A new Nature paper reports that an oral antiviral (4′-fluorouridine) rescued non-human primates from advanced Lassa fever—even when treatment started after animals were already sick and viraemic. www.nature.com/articles/s41...

I don't understand why I need to increasingly pass a CAPTCHA to access a journal article? Is this to prevent AI tools from capturing the data?

It's not too late to get your flu shot. Flu circulates year round but more intensely during flu season. For N. hemisphere: Onset: October–November Peak: December–February (most often January) Decline: March Tail end: April–May (occasionally later) This is why we give shots until the end of February

American Ingenuity - A Cardiology practice advertising on the Diner menu in a retirement community ❤️‍🩹 Somebody has to do the caths!

A new Nipah virus vaccine (HeV-sG-V) has cleared Phase 1, showing no serious safety issues and promising immune responses in 40 adult volunteers—an early but important step for global health security. Learn more: historyofvaccines.org/blog/phase-o...

This was *entirely* preventable.

#FDA has approved a new 1st-in-class oral antibiotic for the treatment of #gonorrhea, which has been making its way through the armamentarium of available antibiotics. Nuzolvence was brought to market through a private-public partnership involving @gardp.bsky.social. www.statnews.com/2025/12/12/f...

A recombinant strain of mpox virus has been isolated from a patient in the UK containing fragments of clade I and clade II virus. Recombination occurs when two strains of virus infect a cell. These events tend to be rare but are well described in poxviruses. www.theguardian.com/world/2025/d...

My 2025 Epic Wrapped just dropped: - 3,817 preop chart reviews - 924 Chat messages - 3,036 EKGs reviewed - 121 PACU order addendums - Top song: “Monitor Not Linked to Charting” - Top artist: Cardiology Clearance and the Echos - Top alert: “Did you mean to order that drug?”

“The National AIDS Memorial, through a partnership with the AIDS Quilt Touch team, presents all 50,000 panels of the AIDS Memorial Quilt in an interactive experience so people around the world can experience the beauty of the Quilt and witness the love and stories stitched into each panel.”

Can we really be grateful for anything in the ID world in 2025? Sure -- plenty of great advances! Here are a half-dozen to celebrate (and be grateful for) in 2025, believe it or not. #idsky blogs.jwatch.org/hiv-id-obser...

Got the flu last year on Thanksgiving and it really sucked. Obviously vaccine is no guarantee you won’t get it, but it’s basically free with no downside and is, imho, a no-brainer. www.scientificamerican.com/article/how-...

Washington state resident dies of new H5N5 form of bird flu

Not the Science we need, but the Science we deserve. "Passengers were significantly more likely to offer their seat when Batman was present (67.21% vs. 37.66%, OR = 3.393, p < 0.001)." More people offered their seat with Batman present, even if they didn't see him. www.nature.com/articles/s44...

“Between 2022 and 2024, resistance to ceftriaxone and cefixime, the primary antibiotics used to treat gonorrhoea, rose sharply from 0.8% to 5% and from 1.7% to 11% respectively, with resistant strains detected in more countries… resistance to ciprofloxacin reached 95%.”

The deadly fever in Ethiopia has been identified as Marburg disease. It’s the first time a Marburg outbreak has been identified in Ethiopia. #IDsky 🧪 www.afro.who.int/countries/et...

Gene therapies are on the cusp of changing how we manage certain chronic diseases. Soon, patients may have a choice between: 1. Daily medication 💊 2. Single injection 💉 Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 | New England Journal of Medicine www.nejm.org/doi/full/10....

Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy | Nature Immunology share.google/FBKwDoY0t8rX... "04_A06, a broadly neutralizing antibody ... with remarkable breadth and potency against multiclade pseudovirus panels (98.5%, 332 strains)"

Ebola is one of the nasty viruses that can hide in the body even after a patient recovers and tests negative. It can reemerge and trigger a new outbreak years later. How do they survive? And how can they be kayoed? n.pr/4hB9gXN

“We should be cautious not to apply AI indiscriminately as a solution in search of a problem... AI will not absolve us from making difficult ethical decisions, especially decisions concerning life and death.”

my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵) www.consumerreports.org/lead/protein...

Neat

“A study, published on Wednesday in the New England Journal of Medicine, showed that last season’s 2024–2025 mRNA COVID vaccines reduced people’s risk of emergency department visits by 29%, their risk of hospitalizations by 39% & their risk of death by 64%” Benefits were seen even if 0 risk factors

A new Cochrane review pooled >100,000 participants across 14 trials of RSV vaccines: - In older adults,RSV vaccines ⬇️ RSV-related lower resp illness by ~70%. - In pregnant people, vaccination halved the risk of infants needing medical care for RSV & ⬇️severe dz by ~74%. www.gavi.org/vaccineswork...

Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social nature.com/articles/d41...

Antagonistic interaction between posaconazole & olorofim in a murine model of invasive pulmonary aspergillosis Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections academic.oup.com/jac/article/...

A drug that provides near-perfect protection against HIV with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope for ending the epidemic.

An excellent project that came together from my time during residency - a great analysis of this difficult bug 🦠! Clinical and microbiologic features of Achromobacter species: a 10-year, multicenter experience | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...

"bUt tHe WhiTe cOuNT iS nOrmAL" I see this pattern of laboratory evaluation almost every day in the ICU anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend what is going on here? #EMIMCC 🧵 #1/5

Some 154 million people in the United States get health care through their employer — and for many, their costs are about to go way up.

Death from sub-acute sclerosing panencephalitis (SSPE) in a child in Los Angeles SSPE is a rare sequel of #measles infection that appears years after the initial infection, and is uniformly fatal. So sorry for this family. As things are going on the US, we'll be seeing more of these cases.

Good to see @bsky.app has emerged as the social media platform of choice for science stuff arstechnica.com/science/2025...

I studied infectious diseases because I get bored easily and needed to be in a field in which there is never a dull moment. The US just confirmed its first human case of myiasis in many decades in a returning traveller from El Salvador. www.npr.org/2025/08/25/n...

Me, signing up for yet another conference with free food

Happy DOTS Day, to those who celebrate. jamanetwork.com/journals/jam...

"But the popular idea that this disease only affects immigrants or travelers is dangerously outdated." www.statnews.com/2025/08/08/c...

Measles is horrible. It has already impacted thousands of young kids. This will only grow as vaccines become less accessible. And when measles is joined by epidemics of rubella, mumps, and polio, we will see children suffer and die at national scale. www.nbcnews.com/health/healt...

🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)! The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs. View guidelines: bit.ly/4lUjN1a