Lisa Genzel (she/her)
@lgenzel.bsky.social
π€ 176
π₯ 225
π 37
in love with memory and sleep research, puts rats, mice and humans into complex, mulit-trial tasks
reposted by
Lisa Genzel (she/her)
Federation of European Neuroscience Societies - FENS
1 day ago
π¬π· #FKNE News from Crete! π§ On 19 September, the FENS-Kavli Network of Excellence held its 2025 Scientific Symposium with the theme βNeuroscience through the Lens of Diversity: Levels, Methods, and Models.β π
https://loom.ly/DyVOs8I
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reposted by
Lisa Genzel (she/her)
Abhilasha Joshi, PhD
6 days ago
1/ π¨ New preprint! π¨ Excited and proud (& a little nervous π ) to share our latest work on the importance of
#theta-timescale
spiking during
#locomotion
in
#learning
. If you care about how organisms learn, buckle up. π§΅π π
www.biorxiv.org/content/10.1...
π» code + data π below π€©
#neuroskyence
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reposted by
Lisa Genzel (she/her)
about 2 months ago
Congratulations to
@anitaluthi.bsky.social
and
@manumameli.bsky.social
ππ
www.linkedin.com/posts/depart...
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Two new full professorships strengthen neuroscience at UNIL! | Department of Fundamental Neurosciences - DNF, University of Lausanne
Two new full professorships strengthen neuroscience at UNIL! We are delighted to announce that two leading researchers from the Department of Fundamental Neurosciences (DNF) of the FBM UNIL - FacultΓ©...
https://www.linkedin.com/posts/department-of-fundamental-neurosciences_neuroscienceresearch-activity-7358055344524124161-ExgG?utm_source=share
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Apply! Great opportunity for young PIs.
add a skeleton here at some point
5 days ago
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reposted by
Lisa Genzel (she/her)
Adrien Peyrache
12 days ago
Stoked to see this paper finally out! It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks. Super fun collaboration with
@mace-lab.bsky.social
and Stuart Trenholm.
www.science.org/doi/10.1126/...
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reposted by
Lisa Genzel (she/her)
Adrien Peyrache
15 days ago
Following up: searching for the distribution of estrogen receptors in the brain, I realized the Allen Brain Atlas is male only. How is it possible that something this fundamental is still missing?
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Cool new findings on interneurons and spatial coding. Nice!
www.science.org/doi/10.1126/...
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Cooperative actions of interneuron families support the hippocampal spatial code
Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of Ξ³-aminobutyric acidβmediated (GABAe...
https://www.science.org/doi/10.1126/science.adv5638
19 days ago
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reposted by
Lisa Genzel (she/her)
Timothy O'Leary
20 days ago
Finding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection. When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.
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reposted by
Lisa Genzel (she/her)
Elliot Smith
19 days ago
*in overtrained mice
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reposted by
Lisa Genzel (she/her)
Eitan Schechtman
26 days ago
New opinion piece!
@amirtal.bsky.social
and I argue that "wake reactivation" is not a scientifically useful construct; It encompasses nonconscious & conscious processes w/ varying levels of elaboration & diverging consequences, leading to conflicting results
authors.elsevier.com/a/1lgli4sIRvW-LQ
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https://authors.elsevier.com/a/1lgli4sIRvW-LQ
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reposted by
Lisa Genzel (she/her)
Abhilasha Joshi, PhD
30 days ago
We are still accepting applications for the
#postdoc
opportunity in the lab π΅ββοΈ π§ More details π Postdoctoral position:
lnkd.in/g4TkRxpM
Research directions:
lnkd.in/eV2iMKGf
Our team and philosophy:
lnkd.in/eh3nnNgq
β¬
add a skeleton here at some point
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reposted by
Lisa Genzel (she/her)
Erin J. Wamsley π§ ππ΄
about 1 month ago
#sleeppeeps
:
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reposted by
Lisa Genzel (she/her)
Mariam Aly
about 1 month ago
I can't quite believe it β I got a new NSF grant! π²π€― I'm incredibly grateful to the program officers & reviewers for their dedication and efforts to keep science going πππΌ So, I'll be hiring! Looking for a postdoc to study competition in memory-guided attention. See flyer for details! π
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reposted by
Lisa Genzel (she/her)
Nico Schuck
about 1 month ago
Delighted to share our work on replay and successor representations! We find replay during very short task pauses in human visual cortex that is linked to learning SRs & happens when learning is implicit. Study led by
@lnnrtwttkhn.bsky.social
#compneuro
#neuroskyence
www.pnas.org/doi/10.1073/...
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Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations | PNAS
Humans can implicitly learn about multistep sequential relationships between events in the environment from their statistical co-occurrence. Theore...
https://www.pnas.org/doi/10.1073/pnas.2507516122
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The lab may be suffering form a slight hexagon and rat obsession.....
about 1 month ago
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reposted by
Lisa Genzel (she/her)
Carmen Sandi
about 1 month ago
Happy to announce our new paper in Nature Communications:
rdcu.be/eBpGY
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social
β¬
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Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus
Nature Communications - Corticotropin-releasing hormone (CRH), known for activating the HPA axis during stress, also acts centrally in the brain. Here, the authors show that CRH modulates thalamic...
https://rdcu.be/eBpGY
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reposted by
Lisa Genzel (she/her)
Thomas Andrillon
about 1 month ago
π€π§ π§ͺ New article! π§ͺπ§ π€ After years of effort led by
@qualiastructure.bsky.social
(Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and
@rherzoga.bsky.social
, the Dream database is now published in
@natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
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reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
about 1 month ago
Disentangling the influences of pre- and postnatal periods on human cortical microstructure
https://www.biorxiv.org/content/10.1101/2025.08.12.669812v1
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reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
about 2 months ago
Sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.
https://www.biorxiv.org/content/10.1101/2025.07.30.665413v1
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reposted by
Lisa Genzel (she/her)
Dan Levenstein
about 2 months ago
Inhibition seems so important for SWRs. One question I find myself asking lately is if this is just a matter of the SWR generating mechanism, or if inhibitory networks are a critical part of replayβs function.
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Parallel emergence of perisomatic inhibition and ripples in the developing hippocampal circuit
During hippocampal Sharp Wave Ripples, sequences of awake coding activities are replayed with a rhythmic timing and high level of synchrony favorable for synaptic plasticity and transfer of informatio...
https://www.biorxiv.org/content/10.1101/2025.06.17.660075v2
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reposted by
Lisa Genzel (she/her)
Anna Schapiro
2 months ago
Super excited to share this one!! Meta-learning sparsity and learning rate gives rise to brain-like gradients of complementary learning systems. So complementary learning systems emerge organically through behavior optimization, and it's not just two of them!!
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reposted by
Lisa Genzel (she/her)
Federation of European Neuroscience Societies - FENS
2 months ago
π£οΈ Opening Plenary Lecture | Guillermina LΓ³pez-Bendito Join us on 4 July 2026 as Prof. Guillermina LΓ³pez-Bendito opens next year's #FENSForum! π§ π Meet all the #FENS2026 speakers:
https://loom.ly/Q_m95o8
#FENSForum!
#FENS2026
#FENS
#NeuroscienceConference
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reposted by
Lisa Genzel (she/her)
Jason Shepherd
2 months ago
While Iβm a big fan of new technologies that help us study human biologyβ¦thereβs still no replacement for animal research! See my article in Gen News.
www.genengnews.com/topics/trans...
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Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
https://www.genengnews.com/topics/translational-medicine/why-we-still-need-animal-research-in-a-world-of-ai-and-organoids/
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reposted by
Lisa Genzel (she/her)
Vikaas Sohal
3 months ago
New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons:
www.biorxiv.org/content/10.1...
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Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility
While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...
https://www.biorxiv.org/content/10.1101/2025.06.27.662040v1.article-metrics
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reposted by
Lisa Genzel (she/her)
Dan Levenstein
3 months ago
Super cool results, and another evidence that theta sweeps are more about (sequential π) prediction following behavior, which happens to be rhythmic in the rodent.
add a skeleton here at some point
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reposted by
Lisa Genzel (she/her)
PLOS Biology
3 months ago
Different
#memory
domains can recruit similar brain areas, but is the role of these overlapping regions shared or domain-specific? This study shows that the function of the
#hippocampus
to preserve the order of sequential behaviors is shared across memory domains
@plosbiology.org
π§ͺ
plos.io/3GzcM6Q
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reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
3 months ago
REMI: Reconstructing Episodic Memory During Intrinsic Path Planning
https://www.biorxiv.org/content/10.1101/2025.07.02.662824v1
0
1
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reposted by
Lisa Genzel (she/her)
Blake Richards
3 months ago
Domestication of dogs induced the expansion of the neocortex and reduction in size of subcortical structures:
www.jneurosci.org/content/45/2...
Reminds me of a theory I once heard that humans basically self-domesticated themselves.
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BrainβBehavior Differences in Premodern and Modern Lineages of Domestic Dogs
Although domestic dogs were the first domesticated species, the nature of dog domestication remains a topic of ongoing debate. In particular, brain and behavior changes associated with different stage...
https://www.jneurosci.org/content/45/27/e2032242025
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reposted by
Lisa Genzel (she/her)
Bill Chopik
3 months ago
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reposted by
Lisa Genzel (she/her)
Marta Silva
3 months ago
π§ Paper out! We investigated how hippocampal and cortical ripples support memory during movie watching. We found that: π¬ Hippocampal ripples mark event boundaries π§© Cortical ripples predict later recall Ripples may help transform real-life experiences into lasting memories!
rdcu.be/eui9l
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Movie-watching evokes ripple-like activity within events and at event boundaries
Nature Communications - The neural processes involved in memory formation for realistic experiences remain poorly understood. Here, the authors found that ripple-like activity in the human...
https://rdcu.be/eui9l
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reposted by
Lisa Genzel (she/her)
Rosanne Rademaker
3 months ago
Curious about the visual human brain, a vibrant and collaborative lab, and pursuing a PhD in the heart of Europe? My lab is recruiting for a 3-year PhD position. More details:
www.rademakerlab.com/job-add
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PhD position β Rademaker lab
https://www.rademakerlab.com/job-add
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reposted by
Lisa Genzel (she/her)
Adrien Peyrache
3 months ago
π§ π¬ This important study demonstrates that slow fluctuations in serotonin release during wakefulness and non-REM sleep correspond to periods of heightened arousal or enhanced offline information processing, especially in the hippocampus. Congrats to the authors!
elifesciences.org/reviewed-pre...
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Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking
https://elifesciences.org/reviewed-preprints/101105
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reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
3 months ago
Large sharp-wave ripples promote hippocampo-cortical memory reactivation and consolidation
https://www.biorxiv.org/content/10.1101/2025.06.27.662061v1
0
6
3
reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
3 months ago
Prior knowledge influences the neural mechanisms supporting memory-based inference
https://www.biorxiv.org/content/10.1101/2025.06.29.662181v1
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reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
3 months ago
Interleaved Replay of Novel and Familiar Memory Traces During Slow-Wave Sleep Prevents Catastrophic Forgetting
https://www.biorxiv.org/content/10.1101/2025.06.25.661579v1
0
2
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reposted by
Lisa Genzel (she/her)
Eitan Schechtman
3 months ago
In this study, led by BlueSky-less superstar undergrad Andrew Lazarus, we set out to ask whether longer reactivation events during sleep lead to more memory benefits. Results suggest this is not the case, but there are some disclaimers. Read all about it!
#sleep
www.sciencedirect.com/science/arti...
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Manipulating memory processing during sleep to explore the critical duration of reactivation events
Newly encoded memories are reactivated and consolidated during sleep. However, how the reactivation of a specific memory unfolds over time is poorly uβ¦
https://www.sciencedirect.com/science/article/abs/pii/S0028393225001460
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reposted by
Lisa Genzel (she/her)
Federation of European Neuroscience Societies - FENS
3 months ago
π Congratulations to the #DiversityPrize Winner! π At the 2025 #FENS Regional Meeting in Oslo, Norway, @network-alba.bsky.social and the FENS-Kavli Network of Excellence (#FKNE) awarded this year's Diversity Prize to Prof. Aikaterini Fotopoulou. π§ π
https://loom.ly/dphSwoM
#DiversityPrize
#FENS
#FKNE)
#DiversityInSTEM
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reposted by
Lisa Genzel (she/her)
Michael Goard
3 months ago
Very happy to see a Transmitter (
@thetransmitter.bsky.social
) piece on our recent work on estrous cycle modulation of hippocampal structure and function. Thanks to Sydney Wyatt (
@sydneywyatt.bsky.social
) for covering the work and its context:
www.thetransmitter.org/neuroendocri...
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Spatial learning circuitry fluctuates in step with estrous cycle in mice
Cyclic shifts in estradiol levels coincide with changes in dendritic spine density and the activity of place cells in the CA1 region of the hippocampus, a new study shows.
https://www.thetransmitter.org/neuroendocrinology/spatial-learning-circuitry-fluctuates-in-step-with-estrous-cycle-in-mice/
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We had a great year of PhD graduations. Starting last December with Adrian Aleman Zapata on Learning-dependent cortico-hippocampal interactions during NonREM sleep, graduating with Cum Laude!
3 months ago
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reposted by
Lisa Genzel (she/her)
Blake Richards
3 months ago
Wonderful to see this piece out! I really think we as a field are converging on a unified account of the hippocampus as a modality agnostic, task-relevant, sequence prediction machine. I bet that within the next decade we will have a complete computational model of the hippocampus. π§ π π§ͺ
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reposted by
Lisa Genzel (she/her)
Anna Schapiro
3 months ago
Yayy check out the most exciting new memory lab!!! You want to go work with Brynn, trust me!!
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reposted by
Lisa Genzel (she/her)
Andrew MacAskill
3 months ago
π¨π¨Job Alertπ¨π¨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept!
@ucl.ac.uk
@ucllifesciences.bsky.social
@uclnpp.bsky.social
post here:
www.nature.com/naturecareer...
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Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324
About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out
https://www.nature.com/naturecareers/job/12840324/
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reposted by
Lisa Genzel (she/her)
Trish Greenhalgh
3 months ago
Thanks for the reminder
@janemunday.bsky.social
. Every summer, I repost this article DROWNING DOES NOT LOOK LIKE DROWNING. To date, I know of FOUR kids who were saved after someone who'd clicked on the link learnt how to spot actual drowning. Take time to read and pass on.
slate.com/technology/2...
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Drowning Doesnβt Look Like Drowning
Drowning is not the violent, splashing call for help that most people expect.
https://slate.com/technology/2013/06/rescuing-drowning-children-how-to-know-when-someone-is-in-trouble-in-the-water.html
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5217
reposted by
Lisa Genzel (she/her)
Delphine Oudiette
3 months ago
What is on your mind when you are about to fall asleep? Help us unravel the diverse ways humans experience this mysterious transition! Please share your unique experiences by filling up this short online questionnaire:
redcap.link/DriftingMinds
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We are hiring! 2 PhD position available on semi-naturalistic behavioral phenotyping and housing projects to increase translation.
www.genzellab.com/we-are-hiring
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We are hiring! β Semantic memory Lab
https://www.genzellab.com/we-are-hiring
3 months ago
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reposted by
Lisa Genzel (she/her)
bioRxiv Neuroscience
3 months ago
Sleep strengthens successor representations of learned sequences
https://www.biorxiv.org/content/10.1101/2025.06.11.658893v1
0
4
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reposted by
Lisa Genzel (she/her)
Georgia Rapti
3 months ago
Excited for upcoming
@fens.org
regional meeting in Oslo! Don't miss the
@fkne-scholars.bsky.social
symposium: protein landscapes on circuit formation & aging across models!
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reposted by
Lisa Genzel (she/her)
Nature Neuroscience
3 months ago
Mouse retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming information to resolve ambiguities
@jvoigts.bsky.social
www.nature.com/articles/s41...
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Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex - Nature Neuroscience
Using a spatial reasoning task in mice, the authors show that retrosplenial cortex encodes spatial hypotheses with well-behaved recurrent dynamics, which can combine these hypotheses with incoming inf...
https://www.nature.com/articles/s41593-025-01944-z?utm_source=bluesky&utm_medium=social&utm_campaign=neuro
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reposted by
Lisa Genzel (she/her)
Mari Sosa
3 months ago
It's officially published!! In my main postdoc work with
@markplitt.bsky.social
and
@lgiocomo.bsky.social
, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. π§΅
www.nature.com/articles/s41...
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A flexible hippocampal population code for experience relative to reward - Nature Neuroscience
Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...
https://www.nature.com/articles/s41593-025-01985-4
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reposted by
Lisa Genzel (she/her)
Nature Neuroscience
4 months ago
Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases, and suggests novel mechanisms of hippocampal memory formation
www.nature.com/articles/s41...
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Formation of an expanding memory representation in the hippocampus - Nature Neuroscience
Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel me...
https://www.nature.com/articles/s41593-025-01986-3?utm_source=bluesky&utm_medium=social&utm_campaign=neuro
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