Sadaf Amin
@sadafamin.bsky.social
š¤ 94
š„ 125
š 14
Assistant Professor medicine.washu.edu studying innate immunity in aging and neurodegeneration.
pinned post!
I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social
, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
10 months ago
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reposted by
Sadaf Amin
Gan Lab
4 months ago
Proud to announce our collaboration with
@blurtonjoneslab.bsky.social
& the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now:
www.biorxiv.org/cgi/content/...
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Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice
Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...
https://www.biorxiv.org/cgi/content/short/2026.01.13.699312v1
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reposted by
Sadaf Amin
Waggoner Lab
6 months ago
Cell membrane stress upon viral infection induces expression and stabilization of host SMPDL3B, which, in turn, degrades cGAMP to suppress cGAS-STING signaling and promote viral replication
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
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reposted by
Sadaf Amin
Junjie Guo
6 months ago
New article
@natneuro.nature.com
by
@yaleneuro.bsky.social
Suzhou Yang &
@kavliatyale.bsky.social
Postdoc Fellow
@zhenlei.bsky.social
, highlighting studies by
@frattalab.bsky.social
Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS
@yalerna.bsky.social
www.nature.com/articles/s41...
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TDP-43 loss brings RNA to a twist ending - Nature Neuroscience
In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now rev...
https://www.nature.com/articles/s41593-025-02065-3
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Single cell isoform profiling by snISOrseq2 reveals broad splicing dysregulation across different cell types in Progranulin-deficient human FTD! Congrats to
@hagentilgner.bsky.social
&
@liganlab.bsky.social
labs! Happy to have played a tiny role in this important study.
www.cell.com/cell-reports...
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A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain
Belchikov et al. conducted a case-control study of splicing in frontotemporal dementia using long-read sequencing. They identified multiple splicing-dysregulation events, including cell-type-specific ...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00969-6
7 months ago
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Great opportunity for neuroscience postdocs!
add a skeleton here at some point
8 months ago
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SPiNES was such a great experience. Highly recommend!
add a skeleton here at some point
9 months ago
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reposted by
Sadaf Amin
John Lukens
10 months ago
Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice
www.sciencedirect.com/science/arti...
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I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social
, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
10 months ago
5
9
2
reposted by
Sadaf Amin
Gan Lab
10 months ago
šØOur new paper is out!šØ We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathyāby suppressing microglial cGASāSTINGāinterferon (IFN) pathway, a key inflammatory axis triggered by tau.
www.sciencedirect.com/science/arti...
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The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cauā¦
https://www.sciencedirect.com/science/article/pii/S1074761325002444?dgcid=author
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The new paper from the Gan lab out today in Immunity shows the Christchurch mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.
www.cell.com/immunity/ful...
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The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses mic...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00244-4
10 months ago
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reposted by
Sadaf Amin
Immunity
10 months ago
Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
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The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. Inhibiting cGAS preserves synapses and mimics R136S-linked gene expression, suggesting that cGAS suppression is a key part of the underlying protective effects of R136S.
http://dlvr.it/TLWFL8
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reposted by
Sadaf Amin
Gan Lab
11 months ago
Our 12th Annual Appel Symposium was a huge success! Record attendance, insightful faculty speakers, and a vibrant poster session sparked meaningful conversations and highlighted the innovative research at WCM. A sincere thank you to all who attended and the WCM teams who made this event possible.
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reposted by
Sadaf Amin
John Lukens
11 months ago
STING deletion protects against amyloid Ī²āinduced Alzheimer's disease pathogenesis - Thanos - 2025 - Alzheimer's & Dementia - Wiley Online Library
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
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STING deletion protects against amyloid Ī²āinduced Alzheimer's disease pathogenesis
INTRODUCTION While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis us...
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70305
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reposted by
Sadaf Amin
Martin Kampmann
12 months ago
www.alz.org/news/2025/ke...
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Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimerās and Dementia Research
The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimerās and dementia research.
https://www.alz.org/news/2025/kennedy-harmful-myths-alzheimers-dementia-research
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reposted by
Sadaf Amin
Fusion Conferences
12 months ago
Our fabulous group for
#TargetAD25
! We have had a wonderful 3 days so far of sharing insights, fostering collaborations, and driving progress toward understanding and treating Alzheimerās diseaseš We canāt wait to celebrate with our gala dinner this evening! šš
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Excited to attend the
#targetAD25
conference. Looking forward to all the great talks and discussions!
@fusionconf.bsky.social
12 months ago
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Congratulations Celeste! š„³
add a skeleton here at some point
about 1 year ago
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you reached the end!!
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