@dfcicancerbio.bsky.social
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reposted by
Dana-Farber Cancer Institute
7 months ago
A new study led by Dipanjan Chowdhury, PhD, co-director of our Center for BRCA and Related Genes, uncovers why some cancers resist PARP inhibitors. The findings could help guide more personalized treatment strategies. Learn more about the study:
bit.ly/4ko5CAq
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Double Negative in Cells Could Undermine PARP Inhibitors
Published: June 10, 2025Updated: June 11, 2025Written by: Beth DoughertyThere are two ways to fix things: the quick way and the careful one. In cancer, cells with BRCA1 mutations tend to choose the quick fix, leaving them vulnerable to medicines like PARP inhibitors.  PARP inhibitors cause DNA to break. When broken strands and sketchy repairs ... Read more
https://bit.ly/4ko5CAq
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reposted by
Milka Kostic
7 months ago
We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...
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Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Assistant/Associate Professor, Chemical Biology job
https://careers.dana-farber.org/job/11813/assistant-associate-professor-chemical-biology-faculty-health-educator-us-ma-boston-450-brookline-ave/
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reposted by
Klingenstein Philanthropies
7 months ago
Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System."
@xingulab.bsky.social
xingulab.dana-farber.org
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reposted by
Dana-Farber News
7 months ago
New research in
@pnas.org
led by
@danafarber.bsky.social
’s Yubao Wang, PhD, in the lab of Tom Roberts, PhD, explored an engineered, degradable form of a small viral protein and made new insights into a key cell growth pathway often hijacked by cancer cells. Read more:
bit.ly/4ezpMpE
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reposted by
Dana-Farber Cancer Institute
7 months ago
In collaboration with Beth Israel Deaconess Medical Center, our new dedicated cancer hospital, projected to open in 2031, will strengthen Boston’s position as a global leader in oncology — and expand access to the most advanced care for patients across the region.
bit.ly/402eQej
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Following State and City Approvals, New Cancer Hospital and Clinical Collaboration Enters Next Phase | Dana-Farber Cancer Institute
With the recent completion of a multi-agency, state and city regulatory process, the clinical collaboration among Dana-Farber Cancer Institute (Dana-Farber), Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical Faculty Physicians at BIDMC (HMFP) is moving forward. The collaboration will support a new Dana-Farber cancer hospital, and the joint clinical teams are developing comprehensive plans to transform cancer care around the world and push the boundaries of research and innovation.
https://bit.ly/402eQej
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reposted by
Boston Protein Design and Modeling Club
7 months ago
quick reminder to join us tonight at
@harvardmed.bsky.social
for a great talk by Colby Ford
@colby.tuple.xyz
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reposted by
Xin Gu Lab at DFCI/HMS
8 months ago
So happy and proud to see our story online!! Thank you, the midnolin team!
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Congratulations Xin!!
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8 months ago
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reposted by
Alba R Meira
8 months ago
Thank you
@shalinhnaik.bsky.social
for participating in our NIC interview series! We really appreciate it 🤩
add a skeleton here at some point
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reposted by
The Jimmy Fund
8 months ago
Scooper Bowl® has officially kicked off at Boston City Hall Plaza! Join us now through Thursday, 12-8pm each day, for unlimited ice cream all to benefit
@danafarber.bsky.social
. 🍦🩷 🎟️:
jimmyfund.gives/BSDay
#boston
#bostonevents
#bostonfoodies
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reposted by
Milka Kostic
9 months ago
NEW PREPRINT ALERT: Buhrlage lab in collaboration with
@irinabezsonova.bsky.social
has developed a new class of USP7 activators!
www.biorxiv.org/content/10.1...
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Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been assoc...
https://www.biorxiv.org/content/10.1101/2025.03.14.643379v1
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reposted by
Dana-Farber News
9 months ago
Congrats to @danafarber.bsky.social’s Brian Wolpin, MD, MPH, a 2025 Giants of Cancer Care by @onclive.bsky.social. Dr. Wolpin is recognized for his remarkable achievements in #gastrointestinal and #pancreatic cancer research and clinical practice. ➡️
bit.ly/3RTq7ZS
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reposted by
Denis Wirtz
9 months ago
188 PhD/graduate fellowships from private foundations, federal agencies and international organizations. Database can be downloaded here:
research.jhu.edu/rdt/funding-...
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reposted by
Dana-Farber News
9 months ago
Congratulations to Eric Smith, MD, PhD, @danafarber.bsky.social on receiving the Outstanding New Investigator Award from @asgct.bsky.social. Smith will present on advancing CAR T cell therapy for cancer immunotherapy.
#ASGCT2025
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reposted by
Dana-Farber News
9 months ago
Happy #NationalNursesWeek! In this video, @danafarber.bsky.social’s Senior VP for Patient Care Services & CNO Anne Gross is joined by a patient’s mother and other members of the NPCS team in discussing what relationship-based care means to them.
bit.ly/44U7WLc
#NationalNursesWeek
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reposted by
Nick Polizzi
9 months ago
Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation.
www.biorxiv.org/content/10.1...
🧵🧪
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Zero-shot design of drug-binding proteins via neural selection-expansion
Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...
https://www.biorxiv.org/content/10.1101/2025.04.22.649862v1
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reposted by
Boston Protein Design and Modeling Club
9 months ago
in case you missed the superb seminar that Ben Fry gave back in January, you can now check out the recording
youtu.be/IgFgAYQrke4
and the preprint
www.biorxiv.org/content/10.1...
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Design of small molecule binding proteins using deep learning
YouTube video by Boston Protein Design and Modeling Club
https://youtu.be/IgFgAYQrke4
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reposted by
Matthew Aquilina
9 months ago
GelGenie has finally been published in Nature Communications (DOI:
doi.org/10.1038/s414...
)! GelGenie is a free, open-source app for the one-click extraction of band data from gel images using AI, all bundled within a cross-platform GUI that can be integrated in your workflow immediately. 🧬
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reposted by
Dana-Farber News
10 months ago
Recently, the Mass Public Health Council voted unanimously to approve
@danafarber.bsky.social
’s plans to build a 300-bed cancer hospital in the Longwood Medical Area. Read more about how a stand-alone cancer hospital will increase equitable access to care:
bit.ly/4jeqCcu
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reposted by
Women in TPD & Induced Proximity
10 months ago
From the team of Angela Koehler and colleagues at MIT, an excellent analysis of how CDK9 degradation differs from CDK9 inhibition with respect to Myc regulation. Congratulations!
www.cell.com/cell-chemica...
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Targeted degradation of CDK9 potently disrupts the MYC-regulated network
Toure et al. investigate a known challenge in CDK9 inhibition—the compensatory increase in MYC levels. They demonstrate that a selective CDK9 degrader with rapid kinetics circumvents this effect, prov...
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00067-4
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reposted by
Women in TPD & Induced Proximity
10 months ago
New preprint out co-led by Hannah Lloyd and Christina Woo at Harvard along with colleagues at the Broad and CeTPD Dundee gives insight on how to detect and discover native substrates of CRBN!
www.biorxiv.org/content/10.1...
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A method for the detection and enrichment of endogenous cereblon substrates
C-Terminal cyclic imides are posttranslational modifications on proteins that are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN). Despite the observation of these modificati...
https://www.biorxiv.org/content/10.1101/2025.03.24.645063v1
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reposted by
Women in TPD & Induced Proximity
10 months ago
Induced proximity modalities at the cell surface! Comprehensive review of emerging approaches and therapeutic possibilities by Carolyn Bertozzi and colleagues at Stanford!
www.nature.com/articles/s41...
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Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
https://www.nature.com/articles/s41587-025-02592-1
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reposted by
Dana-Farber News
10 months ago
Congratulations to
@danafarbernews.bsky.social
’s Matthew Meyerson, MD, PhD, FAACR,
@drchoueiri.bsky.social
, and Alice T. Shaw, MD, PhD, recipients of
@theaacr.bsky.social
2025 Scientific Achievement Awards.
bit.ly/4j7m8om
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reposted by
Nick Polizzi
10 months ago
Worth reading and sharing
docs.google.com/document/d/1...
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Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
https://docs.google.com/document/d/13gmMJOMsoNKC4U-A8rhJrzu_xhgS51PEfNMPG9Q_cmE/mobilebasic#heading=h.b3f2t4qlidd
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reposted by
Dana-Farber News
11 months ago
Congratulations to
@danafarber.bsky.social
’s Bradley Bernstein, MD, PhD, A. Thomas Look, MD, and William R. Sellers, MD, who have been elected as Fellows of
@theaacr.bsky.social
Academy Class of 2025.
#AACRFellows
bit.ly/41RE1Bs
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reposted by
Dana-Farber News
about 1 year ago
Research in Cell Genomics led by @danafarber.bsky.social's Bradley Bernstein, MD, PhD, presents an AI transformer model developed in collaboration with Google Advanced Sciences which can predict gene expression.
https://bit.ly/42zNVsj
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reposted by
Alba R Meira
about 1 year ago
There's no better way to start the new year than by hearing the exciting science of organoids! 🤩 Join us for the first 2025 New Investigator Committee webinar on January 8th.
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