Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns. 🔗 doi.org/10.1093/gbe/evaf097 #genome #evolution #bioinformatics

a quick note on my paper with @jeffspence.bsky.social and @jkpritch.bsky.social on conditional frequency spectra, now out in a @genetics-gsa.bsky.social special issue: doi.org/10.1093/genetics/iyae210

Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]