This sequence optimization technique is also included in the overall sequence optimization tool available on our server: opt.williams.edu (See our publication: www.sciencedirect.com/science/arti...)

In this study, we highlight the importance of the base composition of the first codons for protein expression. An increased abundance of adenine (A) and a decrease in guanine (G) enhance expression and improve mRNA stability. The mediator of this effect is the ribosome.

Our latest paper on protein expression and mRNA stability is out! academic.oup.com/nar/article/... Check out how to increase your protein output with a simple trick. Congratulations to first author @Anna Lipońska, it was a great collaboration with the Aalberts group. #RNAsky #ribosome #EGM

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

A useful toolkit 🧰⚙️

Thanks for the great meeting. It was so nice to see everyone and enjoy great science. 🔤❤️

In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n www.nature.com/articles/s41...

I am very happy to present our new manuscript in collaboration with the Aalbet and Hunt Labs on DNA sequence optimization for high expression in Escherichia coli as well as in in vitro translation assays (doi.org/10.1016/j.jm...)

Super happy to be with the ABC family

It's ABC protein, NOT transporter! We are an inclusive bunch! ❤️ Gregory Boel introducing the morning speakers! #ABC2025

Direct RNA sequencing coupled with adaptive sampling enriches RNAs of interest in the transcriptome www.nature.com/articles/s41... #jcampubs

check it out! RiboGraph: An interactive visualization system for ribosome profiling data at read length resolution 🔎 microprotein 🧬 + 🖥️ www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1... Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Just accepted by CELL as a resource article.

Hi everyone, We are new on Bluesky 😀. We are a group of microbiologists 🧫🔬 interested in mRNA translation mechanisms and regulation. We wish you a wonderful year in 2024 🥳🍾 and will be back soon with more news.

Global regulation via modulation of ribosome pausing by EttA https://www.biorxiv.org/content/10.1101/2023.10.17.562674v1