We are hiring! Interested in being a research coordinator for paediatric antimicrobial trials @mcri.bsky.social? See career10.successfactors.com/sfcareer/job...

Pkpd study in immunocompromised kids showing GCV AUC24 corresponding to 90% maximal suppression and elimination effects was approximately 40-100 mg/L·h. WCC significantly affected the viral decline rate. Time for routine tdm? bpspubs.onlinelibrary.wiley.com/doi/10.1002/... #cmv #pedsid #TxIDChat

Excited to publish this review with kidsdose.org.au network summarising the available clinical trial, pk data and evidence gaps in antibiotic tx for resistant Gram neg infections in kids. www.sciencedirect.com/science/arti.... #idsky #paedsid #pedsid @mcri.bsky.social @lancetrh-wpac.bsky.social

Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky

All you need to know about vancomycin dosing in adults and kids led by @leggwamy.bsky.social and @tonylai.bsky.social

Great comprehensive summary on the safe & effective use of vancomycin in the Australian Prescriber australianprescriber.tg.org.au/articles/saf... Congrats to the authors! @leggwamy.bsky.social @tonylai.bsky.social @feliciadevchand.bsky.social @amandagwee.bsky.social Indy Sandaradura #vancomycin #AMS

Lots of work on this in kids. @amandagwee.bsky.social the BOSS on this topic & @alisonboast.bsky.social her badass sidekick! pubmed.ncbi.nlm.nih.gov/32412727/

Systematic review on posaconazole levels & clinical outcomes of IFI in kids. All but 1 breakthrough IFI occurred with serum levels ≤0.7mg/L. For IFI treatment, no association between trough >1.0mg/L & efficacy. Poor outcomes seen with levels between 0.2-4.8mg/L. pubmed.ncbi.nlm.nih.gov/40037294/

Reduction in sputum pseudomonas bacterial load (live and dead) associated with improvement in FEV1 in children with CF receiving antibiotics. No correlation between change in total sputum bacterial load and improvement in FEV1. #Idsky pubmed.ncbi.nlm.nih.gov/40090524/

📚 Our findings, along with our earlier study showing that #BCGvaccine increased risk of symptomatic [but not severe] #COVID-19, suggest that BCG vaccination does not enhance immunity to #SARSCoV2 or COVID-19 vaccines 🌍✨ #IDsky #Immunosky www.sciencedirect.com/science/arti...

Vaccines and immunization fact sheets you can't find on CDC website anymore are archived at the link below. May be helpful to bookmark this for future reference. www.immunize.org/vaccines/vis...

In this table you can find a summary with different antimicrobials’ penetration into the bile (and the peritoneum). Hope you find it useful! 🙂 #AMSsky #IDOnc #IDSky

Look at that - @bradspellberg.bsky.social gently triggering world war CRO vs CTX! BD or OD??? @alisonboast.bsky.social @amandagwee.bsky.social pubmed.ncbi.nlm.nih.gov/39377581/

🆕💫Retrospective cohort study #CMI AKI is a frequent complication of S. aureus bacteraemia and is associated with 30-day mortality Not “a cute” complication: phenotypic analysis of acute kidney injury in S. aureus bacteraemia #idsky #EMIMCC www.clinicalmicrobiologyandinfection.com/article/S119...

Slipping into 2024 right as the door closes is the publication of the AGAR Kids manuscript depicting antibiotic resistance trends in gram-neg bacteraemia isolates from children over nine years @ausantibiotics.bsky.social #AMR #MedSky #Microsky #IDsky #pediatrics #newarticle doi.org/10.1093/jpid...

Reviews of antimicrobial dosing: 1. Anti-fungals: doi.org/10.1093/ofid... 2. All-antimicrobials: ccforum.biomedcentral.com/articles/10.... Systematic Reviews: 1. Definitions of ECMO infections: www.ajicjournal.org/article/S019... 2. Use of ppx antibiotics: journals.lww.com/asaiojournal...

Broad-Spectrum Antibiotics Linked To Increased Risk For Adverse Drug Events Among Outpatients With CAP #IDSky Antimicrobial stewardship efforts are needed to promote judicious use of antibiotics, and ultimately decrease antibiotic-related ADEs academic.oup.com/cid/advance-...

Linezolid May Be Alternative For Adjunctive Antitoxin Therapy In Adults Hospitalized With Invasive GAS Infection Receiving β-Lactam Therapy #IDSky www.thelancet.com/journals/lan...

#IDSky colleague from New Zealand @maxgbloomfield.bsky.social sent us his study on environmental benefits when they switched TID cefuroxime to once a day ceftriaxone. They had a 383kg waste reduction! Nice to connect with #IDSky across the globe on sustainability. pubmed.ncbi.nlm.nih.gov/38696830/

WHO recommendations for management of serious bacterial infections in infants aged 0–59 days 8 December 2024 www.who.int/publications...

Pharmacodynamic studies indicate that anaerobic killing is optimized when the plasma AUC) to MIC ratio is ≥70:1; the probability of achieving this target with 1000mg/d of metronidazole is > 99% against B. fragilis that exhibit MICs < 2mg/L #idsky #medsky #EMIMCC

🔥The ADAPT-Sepsis RCT🔥 Daily PCT-guided protocol 🔽 total antibiotic duration & had noninferior all-cause mortality compared with standard care. No difference was found in total Abx duration between standard care & daily CRP-guided protocol CRP failure #idsky #EMIMCC jamanetwork.com/journals/jam...

🆕️✨️Retrospective cohort study Oral doxycycline for the treatment of ocular syphilis may be safe and effective as IV penicillin in a selected subset of patients who completed an extended oral antibiotic #idsky #medsky #AMSsky jamanetwork.com/journals/jam...

This #StrepA paper was a LONG labour of love from a great team 😊 Equal first & senior author credits buried at the very end, so I want to highlight the critical contributions of Dr Hannah Frost & @njmoreland.bsky.social & Dr Danika Hill @precisionvaxlab.bsky.social rdcu.be/d2gBV

Thanks @absteward.bsky.social. The link to the original pop pk study on which the dosing regimen was based is pubmed.ncbi.nlm.nih.gov/32412727/

The standard four times daily cephalexin dose makes treatment adherence challenging 🆕️⚡️⚡️Retrospective #JAC Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections #idsky academic.oup.com/jac/article-...

Struggling to keep up with the new (and upcoming) antibiotics for Gram-negatives? A quick reference guide! #AMSsky #IDSky