Linda Tannenbaum (OMF Founder & CEO), Kimberly Hicks (CFO/COO/Treasurer), and Danielle Meadows (VP of Research Programs) are visiting Boston for in-person meetings. Here are a few photos from yesterday’s meeting with researchers from OMF’s Harvard ME/CFS Collaboration. .

OMF Collaboration Investigates Molecular Basis of Post-Exertional Malaise (PEM) 👉 Read more from Dr. Moreau: www.omf.ngo/haptoglobin-.... Key findings: ➡️ After a mild stress challenge, #pwME showed a sharp drop in haptoglobin (Hp) levels, while healthy controls did not. (1/2)

🍂 Did you know you can support OMF research by donating any unwanted vehicles? Cars, trucks, boats, and even farm equipment can help us accelerate our work to end #MECFS and #LongCOVID. Donating is easy, and the pick-up is free. 👉 Get started today: ow.ly/rzTa50UXR3I.

"Metformin is an intriguing multiaction drug that may play a significant role in treating ME/CFS & LC. Although more research is needed to refine dosing and delivery methods, the accumulating evidence suggests it could soon be integrated into clinical practice." #MEcfs #LongCovid

OMF’s Collaborative Center at Montreal, in collaboration with our Melbourne ME/CFS Collaboration, has released a new paper: Circulating Levels of SMPDL3B Define Metabolic Endophenotypes and Subclinical Kidney Alterations in Myalgic Encephalomyelitis. 🔗 ow.ly/uY8x50WW32a

A new review from Melbourne ME/CFS Collaboration, in collaboration with Collaborative Center at Montreal, highlights the potential of metformin, an antidiabetic agent, as a treatment for #MECFS and #LongCOVID. 👉 Read the full publication: ow.ly/uXQJ50WVZax

🧬 Science Wednesdays: What is Proteomics? Proteomics is the study of the set of proteins present in the body at a given time. Looking at protein levels is a critical part of OMF’s large-scale biomarker study, BioQuest. Learn more about proteomics and BioQuest here: www.omf.ngo/what-is-prot....

List of orgs: #MEAction, Solve ME, Open Medicine Foundation, Bateman Horne Center, Renegade Research, Massachusetts ME/CFS & FM Association, Simmaron Research Inc., Complex Disorders Alliance (CODA), and CORe Community, Inc. (COVID Recovery through Community) all

RECOVER TLC clinical trials should include subgroup tracking and analysis for ME/CFS (using IOM criteria), POTS & other forms of dysautonomia, and MCAS. We joined several orgs in signing a letter sent to RECOVER TLC leadership. Letter: ow.ly/nFUa50WU60F #LongCovid #pwME #NIH

In April 2023, we launched OMF StudyME, a free global registry connecting people with #MECFS, #LongCOVID & related diseases to researchers. 🙌 Over 14,000 participants have joined! Sign up in <5 mins & help accelerate research 👉 www.omf.ngo/studyme

Wenzhong Xiao discussing the treatments survey that I have literally already cited twice 😂 Hey, it's great work! 🧪 The paper is here: pubmed.ncbi.nlm.nih.gov/40627388/

New Papers: OMF CRCs at Stanford and Montreal 🌟Microfluidic Assessment of PO2-Regulated RBC Capillary Velocity in #MECFS 🌟Circulating FGF-21 as a Disease-Modifying Factor Associated with Distinct Symptoms and Cognitive Profiles in #ME and #Fibromyalgia ow.ly/6KO350WRwVz

You are invited to join #MEAction for our latest Pillow Writers’ Salon on Thursday, September 18th at 11am PT/2pm ET/7pm UK. Register: us06web.zoom.us/meeting/regi... More about Pillow Writers: pillowwriters.wordpress.com #pwME #MECFS #spoonie #WritingCommunity #LongCovid #MyalgicE

The Mestinon/LDN Life Improvement Trial (LIFT) is seeking eligible research participants now within 300 miles of Brigham and Women’s Hospital at Harvard Medical School. Learn more about the LIFT: clinicaltrials.gov/study/NCT063...

OMF has now received approval from the NIH to access plasma samples collected via the Chronic Fatigue Initiative, bringing the total number of samples for our large-scale ME/CFS biomarker project (BioQuest) to 1,000. 👉 Read the latest BioQuest update: www.omf.ngo/bioquest-upd....

Adverse events are unwelcome occurrences that are associated with a medical intervention (e.g., drug, procedure). They may or may not be directly caused by the medical intervention—they can be caused by interactions with other drugs or other patient factors—and can vary in severity.

The 9th Annual Stanford Working Group Meeting on the Molecular Basis of ME/CFS started today. Today’s agenda is shown in the image. The Community Symposium will take place on Friday, September 5, from 8:00 am to 2:30 pm PST, and requires registration. Register 👉 ow.ly/Upnh50WPPbR.

Long Covid sky, do you know about CURE ID cure.ncats.io an FDA survey on meds you’ve trialed? Results could help show NIH there’s more to study than melatonin & computer games! But CURE ID needs 1000 reports to start crunching data! Will you take the survey—& ask a pal to join too? Here’s how! 🧵

OMF's Melbourne ME/CFS Collaboration published a paper on the results of a systematic review looking at cerebral blood flow in #MECFS and #orthostaticintolerance (OI). 118 studies, including over 9000 participants, were incorporated in the systematic review. ow.ly/QZjw50WNfjt

🧬Science Wednesdays: Cognitive testing Cognitive testing is a way of measuring different parts of brain function. Some of these parts of brain function include reaction time, processing speed, attention, working memory, and spatial processing. (1/3)

From our friends at @meactnet.bsky.social: 📢 Help Us Save Telehealth

ICYMI: OMF's research centers in Uppsala and Melbourne published a study of steroid hormones. The study identified changes in steroid-steroid relationships that indicate there is a dysfunction in HPA axis function and progestogen pathways. 👉 ow.ly/Hh1z50WvrLb

TREATME: the Open Medicine Foundation's Mammoth ME/CFS and Long COVID Treatment Survey Results www.healthrising.org/blog/2025/07... Includes a summary plus an audio version of the full article & separately of the summary #LongCovid #MEcfs #CFS #PwME @openmedf.bsky.social @cortjohnson.bsky.social

Please join the Community Symposium on the Molecular Basis of ME/CFS with opening remarks by Ronald W. Davis, PhD, Stanford University, followed by a welcome from Linda Tannenbaum, OMF CEO. 🗓️ September 5, 2025 ⏲️ 8:00 am – 2:30 pm PST 👉 Register here: ow.ly/9zRg50WIbO3.

From a Mother’s Love to a Global Movement: A Conversation with Linda Tannenbaum, OMF's Founder & CEO. Led by Catarina Santos, co-produced by Joana Ferraz of Millions Missing Aliança—both mothers impacted by #MECFS & #LongCOVID. Watch now👉 ow.ly/L1GL50WJxHW.

🧬Science Wednesdays: Neutrophils #Neutrophils are a type of white blood cell. They play an important role in the immune system, especially in fighting infections. Neutrophil dysfunction is associated with chronic inflammation, making them particularly relevant for #MECFS.

From Ronald W. Davis, PhD: Community Symposium on the Molecular Basis of ME/CFS returns! 👉 Register for the Community Symposium: ow.ly/vm1S50WIbO2. #pwME #MECFS

Biosamples are biological samples collected from people for research or medical purposes. 👉 Learn more about #biosamples and a project conducted at OMF’s Collaborative Center at Uppsala, in which the team is analyzing the CSF of #pwME: www.omf.ngo/types-of-bio....

In this video, Solve M.E. Lived Experience Taskforce (LET) member Hollis Mickey talks about why it’s important that the language of blame be avoided when discussing #SevereME. #UnitedForME #SevereMEDay

On Aug. 8, we mark #SevereMEDay & raise awareness by elevating the experiences of those impacted. We also share free educational resources to help people understand the impact of #SevereME. Learn more here: ow.ly/KBjQ50WCcMh #UnitedForME #LearnFromME

by Bente Kubin "Time feels weird when your life stands still. When you can hardly create new memories. You’re in some kind of strange time capsule, trapped and hidden away under unbearable conditions, while the world outside carries on as usual." ow.ly/fIpL50WCg7y

On this Severe ME Awareness Day, I present to you my newest exhibition: “In the Absence of Light”. 1/3 www.aquietstorm.me/in-the-absen... #MECFS #SevereME #SevereMEday #pwME #Photography

In honor of #SevereMEday, #MEAction is honored to share the Severe ME Artists Project 2025! www.meartistsproject.com/severe-me-ar... Over 100 of you submitted photos, drawings, writing, music and videos of your work for our 5th Severe ME Artists Project! #SevereME #UnitedForME #pwME

From Brent's mom: Brent worked with OMF. He is now severely ill and house-bound. He can’t read or write. He can barely communicate but wanted to share this message with other patients.

"Today we honor the sickest among us. The ones who have been least lucky among some of the least lucky people on earth..." A Moment of Silence for Severe ME/CFS Patients by @DafoeWhitney: ow.ly/QrCt50WBCZZ #MEmomentOfSilence #UnitedForME

In honor of #SevereMEDay, we’re launching #UnitedForME, a shared hashtag to amplify voices, art, and education from the Severe ME community. Join @openmedf.bsky.social, @solveme.bsky.social, @meactnet.bsky.social & @batemanhornecenter.bsky.social in uplifting voices that need to be heard. 💙

🧬Science Wednesdays: HPA axis The hypothalamus-pituitary-adrenal (HPA) axis is the communication between three organs: the hypothalamus region of the brain, the pituitary gland, and the adrenal gland. The HPA axis is a major part of the body’s stress management system.

RECOVER–Treating Long COVID (TLC) Workshop: Pathways to Treatments 🗓️ When? September 9–10, 2025 📍 Where? The Bethesdan Hotel in Bethesda, MD / Online 🔗 Explore the agenda and register here: ow.ly/43ST50WAa75.

At OMF, we’re committed to sharing accurate, up-to-date information about our research and initiatives. We would be grateful if you could take a few minutes to complete OMF's 2025 Community Survey. 💬 Thank you for your support! 🔗 Take the survey: ow.ly/TT1250WyNv6.

Now Available: IIMEC17 Conference Presentations OMF’s research team was proud to present some of our research projects to the conference attendees. Today, we are delighted to share recordings of the available presentations. 👉 Watch the recordings: www.omf.ngo/iimec17-recordings.

🧬Science Wednesdays: #CPET A cardiopulmonary exercise test (CPET) is a way to measure how your heart and lungs work during physical exertion. It’s most commonly done using an exercise bike, evaluating oxygen intake and other vitals throughout a gradual increase in workload.

➡️ Add impact to your inbox! Subscribe to OMF newsletter 👉 ow.ly/oukr50WwRvo. 🌏 Located in Australia? Sign up for OMF Australia newsletter 👉 ow.ly/xEOG50WwRvp. Get the latest OMF research, announcements & more. Your information stays private. Unsubscribe anytime.

In honor of the ADA’s 35th anniversary tomorrow, we would like to share this @amexperiencepbs.bsky.social documentary Change, Not Charity. A full documentary might be too much for some but there are also links to articles, galleries & short videos. www.pbs.org/wgbh/america... #ADA35 #pwME

OMF's research centers in Uppsala and Melbourne published a study of steroid hormones. The study identified changes in steroid-steroid relationships that indicate there is a dysfunction in HPA axis function and progestogen pathways. 👉 Read the paper summary: ow.ly/eiNt50WvrLa

🧬Science Wednesdays: microRNA You may have heard the phrase “DNA makes RNA makes protein”, and while that’s largely true, micro ribonucleic acids (miRNAs) break that mold. miRNAs are small RNAs that don’t code for proteins (i.e., they are non-coding RNAs).

Dr. David Systrom recently attended the International ME/CFS Conference 2025 in Berlin, Germany. As part of the conference, he gave two presentations: 🔹 Circulatory dysfunction in #MECFS 🔹 OMF’s Life Improvement Trial (LIFT) Watch the recordings: ow.ly/heaj50Wtmqi.

Every July, we recognize Disability Pride Month—a time to honor the signing of the Americans with Disabilities Act (ADA) in 1990. 🌍 According to the WHO, an estimated 1.3 billion people—1 in 6 globally—experience significant disability.

In collaboration with patient-scientist Martha Eckey, PharmD, Wenzhong Xiao, PhD, and his team have released a publication on a project analyzing patient-reported treatment outcomes in #MECFS and #LongCOVID. Read about this study in Health Rising👉 ow.ly/KOAh50WrPSJ.

🎥 ICYMI Video Update: A Muscle Biopsy Study to Understand the Molecular Mechanisms of #PEM 👉 Watch the interview and learn more about this study: ow.ly/leAU50Wkrk8.

🧬Science Wednesdays: EEG An electroencephalogram, or #EEG, is a way to measure brain activity. As part of an EEG, electrodes are placed on a person’s scalp, which read electrical signals coming from the brain and convert them into a visual pattern that can be analyzed.