Josh Koenig
@koenigjfe.bsky.social
📤 372
📥 629
📝 8
reposted by
Josh Koenig
Arinjay Banerjee
9 months ago
It was wonderful to share the lab’s work with colleagues at McMaster University and their Immunology Research Center. Thanks, Amy and Josh, and lovely to meet colleagues at my Alma mater.
#LZCI
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reposted by
Josh Koenig
bioRxiv Immunology
10 months ago
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis
https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1
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What a great thing to wake up to! Thank you CIHR for the support for the lab to dive into the mechanisms of immune memory in allergy!
10 months ago
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reposted by
Josh Koenig
Centre for Discovery in Cancer Research (CDCR) - McMaster U
11 months ago
Check out the latest publication by
@khoulahan.bsky.social
!
add a skeleton here at some point
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reposted by
Josh Koenig
Joshua McGrath
11 months ago
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell!
@cellpress.bsky.social
www.cell.com/molecular-ce...
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Mutability and hypermutation antagonize immunoglobulin codon optimality
McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00988-2
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reposted by
Josh Koenig
Edward Nirenberg
11 months ago
would be curious about
#hemesky's
input here- any concern about inducing hypercoagulability through vaccine adjuvantation with thrombopoeitin (TPO)? Awesome study that also highlights species-specific differences in immunity (e.g. plasma cell APRIL dependence) and the consistency across...
add a skeleton here at some point
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reposted by
Josh Koenig
Jeroen Guikema
11 months ago
Really interesting study on the mutability and codon optimality of human IgV genes, showing an inverse relation. Mutability appears to trump codon optimality for immunoglobulin genes!
www.sciencedirect.com/science/arti...
🩸🔬
#b-cells
#immunology
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Mutability and hypermutation antagonize immunoglobulin codon optimality
The efficacy of antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation. Des…
https://www.sciencedirect.com/science/article/abs/pii/S1097276524009882?via%3Dihub
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reposted by
Josh Koenig
Jen Gommerman
12 months ago
So proud
@theonlylabever.bsky.social
who persevered with this impactful project. First author Dr. Kyle Burrows is now lunching his own lab at SFU. Nicely done!
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A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.
https://www.cell.com/cell/abstract/S0092-8674(24)01336-9?dgcid=raven_jbs_aip_email
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reposted by
Josh Koenig
Ivan Zanoni
12 months ago
#LocationLocationLocation
! Burrows, Mortha &co show
@cellcellpress.bsky.social
that a gut commensal protozoan induces ILC2 migration from the gut to the lung & interaction with T & B cells, recruiting lung eosinophils that shield the vasculature aggravating
#asthma
but protecting from
#Mycobacterium
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Redirecting
https://doi.org/10.1016/j.cell.2024.11.020
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reposted by
Josh Koenig
Vienna Airway Lab
12 months ago
Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different...
#Immunosky
#Immunology
www.science.org/doi/epdf/10....
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Architecture of the high-affinity immunoglobulin E receptor
Structural analysis reveals species-specific differences in how the antibody IgE binds to its receptor FcεRI.
https://www.science.org/doi/epdf/10.1126/scisignal.adn1303
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reposted by
Josh Koenig
IMAGE Lab
12 months ago
B CELL FUN FACT: Secrets of the GC #2 There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! NaĂŻve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
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The total mass, number, and distribution of immune cells in the human body | PNAS
The immune system is a complex network of cells with critical functions in health and disease. However, a comprehensive census of the cells compris...
https://www.pnas.org/doi/10.1073/pnas.2308511120
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reposted by
Josh Koenig
Arthur Mortha
about 1 year ago
Very excited to share the most recent work from
#theonlylabever
out in
@jexpmed.bsky.social
We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis. Hope you will find this interesting:
doi.org/10.1084/jem....
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The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA | Journal of Experimental Medicine | Rockefeller University Press
The gut commensal protist Tritrichomonas musculis (T.mu) boosts T cell–dependent IgA. T.mu-driven IgA modifies the commensal bacterial microbiota and impro
https://doi.org/10.1084/jem.20221727
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reposted by
Josh Koenig
Jon Lim, MRCP PhD
about 1 year ago
🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇
bioart.niaid.nih.gov
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reposted by
Josh Koenig
Kim Good-Jacobson
about 1 year ago
Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!
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reposted by
Josh Koenig
Justin J. Taylor, PhD
almost 2 years ago
Thanks to Josh Koenig, Allyssa Phelps, & Diego Pazos-Castro for taking the lead and writing up the protocol below initially developed during the early days of my postdoc. Discussed in this
go.nature.com/3OxA5yD
“behind the paper” post.
www.nature.com/articles/s41...
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Production and use of antigen tetramers to study antigen-specific B cells - Nature Protocols
Antigen-specific B cells constitute a small proportion of the total B cell population, making identification for downstream analysis challenging. Here, this is achieved by pairing fluorescent antigen ...
https://www.nature.com/articles/s41596-023-00930-8
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