Thanks @airr-community.bsky.social for the invitation to share our work on codon optimality in immunoglobulins! www.cell.com/molecular-ce... www.youtube.com/watch?v=WSku...

The next AIRR-C seminar is scheduled for June 26 at 1600 CET, 1000 ET, 700 PT with Rohit Sing @rohitsingh8080.bsky.social (antibody PLMs) and @joshuamcgrath.bsky.social (immunoglobulin codon mutability). Register here: antibodysociety.org/the-airr-com...

Exciting study from the Tan group about a cryptic, immunosubdominant but protective Ab epitope on Plasmodium sporozoites. Generated only through cleavage and pyroglutamation of PfCSP surface protein. Big news for epitope-targeting malaria vaccines and mAb therapeutics www.science.org/doi/10.1126/...

Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity www.pnas.org/doi/10.1073/... @pnas.org

Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social www.cell.com/molecular-ce...