Nicole Mather
@nicolemather.bsky.social
📤 144
📥 267
📝 17
Science. Data Science IBM. NED at Sanger and Cell & Gene Therapy Catapult. Ex OLS. Love Outdoors
reposted by
Nicole Mather
Cell and Gene Therapy Catapult
4 months ago
In the first investment from the CGT Catapult as part of the Cross-Catapult Investment Pilot, Spliceor has received funding to accelerate the pre-clinical development of its trans-splicing
#GeneTherapy
platform for liver cancer. Learn more:
lnkd.in/e4h9xNkQ
@catapultnetwork.bsky.social
0
1
1
reposted by
Nicole Mather
Cell and Gene Therapy Catapult
5 months ago
@nicolemather.bsky.social
delivered a powerful talk on how AI & digital technologies can transform ATMP production at our CGT Catapult & Alliance for Regenerative Medicine Industrialisation workshop today! Key areas included: data standardisation, platform scale out & flexible automation.
0
0
1
reposted by
Nicole Mather
Cell and Gene Therapy Catapult
6 months ago
Following the ATI North event last month, we reflect on key takeaways from the “Digitally Driven” panel chaired by
@nicolemather.bsky.social
. Discussion explored how digital tools are helping to reduce the cost of
#ATMPs
and unlock patient-centric therapies. Read the blog:
ow.ly/u0Fy50VZQQC
0
0
1
Looking forward to speaking at
#ReWired2025
about how
#AI
is already transforming
#NHS
#Productivity
away from the front line, reducing waiting lists & time taken for clinical coding & HR support. Talking about how to
#spread
&
#scale
this approach nationally so patients and staff can benefit more
8 months ago
0
1
0
reposted by
Nicole Mather
Wellcome Sanger Institute
8 months ago
By mapping how thousands of inherited genetic changes play a role in developing chronic conditions, researchers have uncovered new connections between our genes and health 🧬
www.sanger.ac.uk/news_item/tr...
loading . . .
Translating genetic changes into future health impact
New resource helps bridge the gap between identifying genetic changes linked to health conditions and understanding how these changes impact biological processes.
https://www.sanger.ac.uk/news_item/translating-genetic-changes-into-future-health-impact/
1
9
4
reposted by
Nicole Mather
Eric Topol
9 months ago
A treasure chest of all of our immune system exposures and responses is hiding in our B and T cell receptors. Now that's being decoded to make diagnoses.
erictopol.substack.com/p/the-first-...
loading . . .
The First Diagnostic Immunome
A Big Step Forward By Sequencing B and T Cell Receptors Plus A.I.
https://erictopol.substack.com/p/the-first-diagnostic-immunome
0
160
30
reposted by
Nicole Mather
Eric Topol
9 months ago
New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI
thelancet.com/journals/lan...
loading . . .
Screening performance and characteristics of breast cancer detected in the Mammography Screening with Artificial Intelligence trial (MASAI): a randomised, controlled, parallel-group, non-inferiority, ...
The findings suggest that AI contributes to the early detection of clinically relevant breast cancer and reduces screen-reading workload without increasing false positives.
https://thelancet.com/journals/landig/article/PIIS2589-7500(24)00267-X/fulltext
38
1363
439
reposted by
Nicole Mather
Ethan Mollick
9 months ago
Been waiting for someone to test this and see if it works - can multiple AI agents fact-checking each other reduce hallucinations? The answer appears to be yes - using 3 agents with a structured review process reduced hallucination scores by 96% across 310 test cases.
arxiv.org/pdf/2501.13946
8
139
33
Great to meet so many folks at
#FOG2025
Festival of Genomics today to talk about super interesting stuff our research teams are doing with biomedical foundation models in omics, agentic workflows in labs and pB storage solutions. Booth 81 if you are there tomorrow?
10 months ago
0
1
0
reposted by
Nicole Mather
Sjors Scheres
10 months ago
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the
@mrclmb.bsky.social
! 🥳 Re-posts appreciated.
www.nature.com/naturecareer...
loading . . .
Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196
Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK
https://www.nature.com/naturecareers/job/12835196/research-group-leader-tenure-track-structural-studies-lmb-2549
1
73
75
reposted by
Nicole Mather
Eric Topol
10 months ago
Something you don't see every day! Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins
www.cell.com/cell/fulltex...
open-access
7
406
107
reposted by
Nicole Mather
Eric Topol
10 months ago
How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien!
www.cell.com/cell/abstrac...
www.science.org/content/arti...
14
399
112
reposted by
Nicole Mather
Hetan Shah
10 months ago
I'm honoured to have been asked to give this year's
@healthfoundation.bsky.social
annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested
www.health.org.uk/events/hype-...
loading . . .
Hype, hallucination, hope – what might AI mean for our health?
In our fifth REAL Challenge annual lecture, Hetan Shah will warn of the risk of rushing breathlessly to unleash technology. He will explore how policymakers can navigate the hype and critically assess...
https://www.health.org.uk/events/hype-hallucination-hope-what-might-ai-mean-for-our-health
3
55
24
reposted by
Nicole Mather
Hetan Shah
11 months ago
The Department for Energy Security and Net Zero is looking for members for a new Science and Technology Advisory Council and are looking for expertise which includes economics, social science and statistics. £350 a day. 12 vacancies
apply-for-public-appointment.service.gov.uk/roles/8465
loading . . .
Appointment details – Department for Energy Security and Net Zero - Science and Technology Advisory Council (STAC) - Members – Apply for a public appointment – GOV.UK GOV.UK
https://apply-for-public-appointment.service.gov.uk/roles/8465
1
8
13
reposted by
Nicole Mather
Emma Barrett
11 months ago
Ofcom looking for NEDs to join new Advisory Committee on Disinformation & Misinformation. 7-10 days (paid) per year. Closes 13 Jan Good opportunity for researchers with expertise in "disinformation, misinformation, foreign interference or related areas"
ofcom.wd3.myworkdayjobs.com/en-US/Ofcom_...
3
18
30
reposted by
Nicole Mather
Drew Armstrong
11 months ago
Lilly released it's head-to-head with Wegovy today and it appears to have a meaningful edge on long-term weight loss (handy chart from Liz Cairns)
1
2
2
reposted by
Nicole Mather
Ben Lehner
12 months ago
Can a single small molecule rescue the stability of nearly all mutations in a protein? Our new preprint by Taylor Mighell
www.biorxiv.org/content/10.1...
thread on the other place:
x.com/taylor_mighe...
loading . . .
A pharmacological chaperone stabilizer rescues the expression of the vast majority of pathogenic variants in a G protein-coupled receptor
Reduced protein stability is the most frequent mechanism by which rare missense variants cause disease. A promising therapeutic avenue for treating destabilizing variants is pharmacological chaperones...
https://www.biorxiv.org/content/10.1101/2024.11.28.625821v1
3
68
25
Today we welcomed
#NHS
leaders to our
#IBM
office along with
#HSJ
to discuss how digital will reshape healthcare in future.
11 months ago
0
2
0
The way science is being done has been transformed by AI. Thought provoking essay from the
@deep-mind.bsky.social
team
open.substack.com/pub/aipolicy...
#GeneSky
#DataScience
loading . . .
A new golden age of discovery
Seizing the AI for Science opportunity
https://open.substack.com/pub/aipolicyperspectives/p/a-new-golden-age-of-discovery?r=2jc72d&utm_medium=ios
12 months ago
0
2
0
Scaling up cell & gene therapies and reducing cost of goods so many more patients can benefit is urgent. I spoke with Matthew Durdy, our CEO at
@cgtcatapult.bsky.social
about how tech can help. Thank you to
#CellTherapiesIntegrates
for the invite
#automation
#predictiveanalytics
#digitaltwins
#data
12 months ago
1
5
0
Weekend reading.. Scale proteomics gives insights into disease progression, aging and related druggable targets.
#ProteomicSky
#GeneSky
add a skeleton here at some point
12 months ago
0
2
1
Delighted to contribute
#HumanCellAtlas
pics to
#FluorescenceFriday
. Long time since I took some myself but proud of the
#WellcomeSanger
contribution here - shows human thymus
@mehurles.bsky.social
12 months ago
1
5
0
reposted by
Nicole Mather
Honey de G
12 months ago
Wes Streeting comes in as a surprise speaker at the
#HSJAwards
. He’s “only been in office for four Liz Trusses” but received warmly amidst an audience of 1700 amazing health and social care champions.
0
3
1
reposted by
Nicole Mather
Kashif Pirzada, MD
12 months ago
A women-led team of 20, working remotely, is showing up a trillion dollar megacorp. Truly inspiring.
173
12036
2388
reposted by
Nicole Mather
Eric Topol
12 months ago
A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...
7
450
110
Frosty sunrise today
12 months ago
0
2
0
reposted by
Nicole Mather
Matthew Freeman
12 months ago
Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2
docs.google.com/spreadsheets...
loading . . .
@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists
https://docs.google.com/spreadsheets/d/1r74eYlX9CxrauOjPWUwYrzVfQGkeKs5HsxxQCqlaceY/edit?gid=0#gid=0
40
206
140
November skies
12 months ago
0
0
0
Hooray. The community is back. With just the good bits
#science
#genomics
#datascience
#patientimpact
12 months ago
0
8
2
you reached the end!!
feeds!
log in