In the first investment from the CGT Catapult as part of the Cross-Catapult Investment Pilot, Spliceor has received funding to accelerate the pre-clinical development of its trans-splicing #GeneTherapy platform for liver cancer. Learn more: lnkd.in/e4h9xNkQ @catapultnetwork.bsky.social

@nicolemather.bsky.social delivered a powerful talk on how AI & digital technologies can transform ATMP production at our CGT Catapult & Alliance for Regenerative Medicine Industrialisation workshop today! Key areas included: data standardisation, platform scale out & flexible automation.

Following the ATI North event last month, we reflect on key takeaways from the “Digitally Driven” panel chaired by @nicolemather.bsky.social. Discussion explored how digital tools are helping to reduce the cost of #ATMPs and unlock patient-centric therapies. Read the blog: ow.ly/u0Fy50VZQQC

Looking forward to speaking at #ReWired2025 about how #AI is already transforming #NHS #Productivity away from the front line, reducing waiting lists & time taken for clinical coding & HR support. Talking about how to #spread & #scale this approach nationally so patients and staff can benefit more

By mapping how thousands of inherited genetic changes play a role in developing chronic conditions, researchers have uncovered new connections between our genes and health 🧬 www.sanger.ac.uk/news_item/tr...

A treasure chest of all of our immune system exposures and responses is hiding in our B and T cell receptors. Now that's being decoded to make diagnoses. erictopol.substack.com/p/the-first-...

New: The largest medical A.I. randomized controlled trial yet performed, enrolling >100,000 women undergoing mammography screening The use of AI led to 29% higher detection of cancer, no increase of false positives, and reduced workload compared with radiologists w/o AI thelancet.com/journals/lan...

Been waiting for someone to test this and see if it works - can multiple AI agents fact-checking each other reduce hallucinations? The answer appears to be yes - using 3 agents with a structured review process reduced hallucination scores by 96% across 310 test cases. arxiv.org/pdf/2501.13946

Great to meet so many folks at #FOG2025 Festival of Genomics today to talk about super interesting stuff our research teams are doing with biomedical foundation models in omics, agentic workflows in labs and pB storage solutions. Booth 81 if you are there tomorrow?

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

Something you don't see every day! Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins www.cell.com/cell/fulltex... open-access

How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien! www.cell.com/cell/abstrac... www.science.org/content/arti...

I'm honoured to have been asked to give this year's @healthfoundation.bsky.social annual REAL Challenge lecture - on the theme of AI and health. Thursday 13th Feb in person / online. You can register here and please do share with any networks that may be interested www.health.org.uk/events/hype-...

The Department for Energy Security and Net Zero is looking for members for a new Science and Technology Advisory Council and are looking for expertise which includes economics, social science and statistics. £350 a day. 12 vacancies apply-for-public-appointment.service.gov.uk/roles/8465

Ofcom looking for NEDs to join new Advisory Committee on Disinformation & Misinformation. 7-10 days (paid) per year. Closes 13 Jan Good opportunity for researchers with expertise in "disinformation, misinformation, foreign interference or related areas" ofcom.wd3.myworkdayjobs.com/en-US/Ofcom_...

Lilly released it's head-to-head with Wegovy today and it appears to have a meaningful edge on long-term weight loss (handy chart from Liz Cairns)

Can a single small molecule rescue the stability of nearly all mutations in a protein? Our new preprint by Taylor Mighell www.biorxiv.org/content/10.1... thread on the other place: x.com/taylor_mighe...

Today we welcomed #NHS leaders to our #IBM office along with #HSJ to discuss how digital will reshape healthcare in future.

The way science is being done has been transformed by AI. Thought provoking essay from the @deep-mind.bsky.social team open.substack.com/pub/aipolicy... #GeneSky #DataScience

Scaling up cell & gene therapies and reducing cost of goods so many more patients can benefit is urgent. I spoke with Matthew Durdy, our CEO at @cgtcatapult.bsky.social about how tech can help. Thank you to #CellTherapiesIntegrates for the invite #automation #predictiveanalytics #digitaltwins #data

Weekend reading.. Scale proteomics gives insights into disease progression, aging and related druggable targets. #ProteomicSky #GeneSky

Delighted to contribute #HumanCellAtlas pics to #FluorescenceFriday. Long time since I took some myself but proud of the #WellcomeSanger contribution here - shows human thymus @mehurles.bsky.social

Wes Streeting comes in as a surprise speaker at the #HSJAwards. He’s “only been in office for four Liz Trusses” but received warmly amidst an audience of 1700 amazing health and social care champions.

A women-led team of 20, working remotely, is showing up a trillion dollar megacorp. Truly inspiring.

A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells A Wikipedia of our cells, a "remarkable achievement" nature.com/articles/d41... nature.com/immersive/d4...

Frosty sunrise today

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

November skies

Hooray. The community is back. With just the good bits #science #genomics #datascience #patientimpact