Michael Lustgarten, PhD
@conquer-aging-123y.bsky.social
š¤ 53
š„ 12
š 242
Scientist
New YouTube video!
www.youtube.com/watch?v=znRN...
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Blood Test #2 In 2026: Biological Age, CVD Risk, Correlations With Diet
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=znRN7MHohrU
5 days ago
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New YT video, featuring
@drgjmurphy.bsky.social
!
www.youtube.com/watch?v=WJfG...
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Unlocking The Secrets Of Exceptional Longevity
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=WJfG87-eEDE
12 days ago
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Ergothioneine Improves Memory, Sleep, Liver Function, And Neurodegeneration
youtu.be/wrLBKNWjM_0
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Ergothioneine Improves Memory, Sleep, Liver Function, And Neurodegeneration
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://youtu.be/wrLBKNWjM_0
19 days ago
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Aging Mechanisms, And How To Fix It (Featuring Michael Levin, PhD)
www.youtube.com/watch?v=KGlG...
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Aging Mechanisms, And How To Fix It (Featuring Michael Levin, PhD)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=KGlGuEQm3q8
23 days ago
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New YT video!
www.youtube.com/watch?v=AayE...
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Do Centenarians Have A Unique Immune System?
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=AayEgYBQUDs&t=1s
26 days ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
about 1 month ago
Therapeutic mitochondria transplants made more efficient with targeting tool
www.nature.com/articles/d41...
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Therapeutic mitochondria transplants made more efficient with targeting tool
A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.
https://www.nature.com/articles/d41586-026-00910-4
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New YT video!
youtu.be/dihUtPWd1W4
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The Immune System Impacts Longevity: What To Measure
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://youtu.be/dihUtPWd1W4
about 1 month ago
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New YT video!
www.youtube.com/watch?v=zHD9...
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Tracking A Biomarker Of Neurodegeneration (22-Test Analysis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=zHD9fxL92Ps
about 1 month ago
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I spy a familiar name on the author list...
add a skeleton here at some point
about 2 months ago
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New YT video!
www.youtube.com/watch?v=yKCN...
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Consistently Higher HRV, Lower RHR Since 2018
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=yKCNkAc3RFg
about 2 months ago
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New YT video!
www.youtube.com/watch?v=ton-...
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Quantifying Biological Age: Test #1 In 2026
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=ton-0pT0Wbo
about 2 months ago
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New YT video!
www.youtube.com/watch?v=UYB4...
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Aging, Cancer, And Rejuvenation (Featuring Drs. Michael Levin And Leo Pio-Lopez)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=UYB4pHQ9RaA
2 months ago
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New YT video!
www.youtube.com/watch?v=i9TL...
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Predicting Heart Disease Risk With ApoB, LP(a), and VLDL
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=i9TL2mrFEEY
2 months ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
2 months ago
Memory loss is fuelled by gut microbes in ageing mice
www.nature.com/articles/d41...
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Memory loss is fuelled by gut microbes in ageing mice
If confirmed in people, the finding might lead to gut-targeted therapies that could reverse cognitive decline.
https://www.nature.com/articles/d41586-026-00768-6
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reposted by
Michael Lustgarten, PhD
Aging Science News
2 months ago
Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality
journals.plos.org/plosbiology/...
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Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality
Blood levels of neurofilament light chain (NfL) increase with age in healthy humans and can predict all-cause human mortality, but is this true across species? This study shows that NfL age-related bl...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003606
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reposted by
Michael Lustgarten, PhD
Aging Science News
2 months ago
Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice
www.cell.com/cell/abstrac...
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Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice
Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3ā²-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.
https://www.cell.com/cell/abstract/S0092-8674%2826%2900103-0
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reposted by
Michael Lustgarten, PhD
Aging Science News
3 months ago
Predicting onset of symptomatic AlzheimerŹ¼s disease with plasma p-tau217 clocks
www.nature.com/articles/s41...
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Predicting onset of symptomatic AlzheimerŹ¼s disease with plasma p-tau217 clocks - Nature Medicine
Plasma p-tau217 tests used to develop clocks that predict when cognitively unimpaired individuals would develop symptoms of AlzheimerŹ¼s disease.
https://www.nature.com/articles/s41591-026-04206-y
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New YT video!
www.youtube.com/watch?v=G7Ds...
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Elite Mobility At 75, Featuring John Ranello
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=G7Ds-BMYFcg&t=1s
3 months ago
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New YT video!
www.youtube.com/watch?v=dDiv...
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Rejuvenation And Dramatic Lifespan Extension Is Here!
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=dDivek4dJ9Q
3 months ago
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New YT video!
www.youtube.com/watch?v=iGl5...
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Is Ketogenesis Required For Metabolic Improvements On A Calorie-Restricted Diet?
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=iGl5mz-lNYA
3 months ago
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New YouTube video!
www.youtube.com/watch?v=Cum2...
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A Deep Dive Into The āLongevity Vitaminā, Ergothionine
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=Cum2NhMsDwU
3 months ago
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The video is now live on YT!
www.youtube.com/watch?v=gqTq...
B2M is a biomarker that (imo) we should try to optimize
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Beta-2-Microglobulin Is Bad For Neurogenesis: What's My Data? (6-Test Analysis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=gqTqaMAq-6A
3 months ago
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Now live on YT!
www.youtube.com/watch?v=wq56...
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Unraveling The Oral Microbiomeās Role In Alzheimerās Disease
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=wq567q8RbrU
4 months ago
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New YT video!
www.youtube.com/watch?v=ohUF...
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Visceral Fat Removal Extends Lifespan: Who Has The Lowest?
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=ohUFqo8G2_c
4 months ago
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reposted by
Michael Lustgarten, PhD
Klaus Townsend
4 months ago
The inaugural season of the @LongevityWorldC has officially concluded. Congratulations to Mike Lustgarten for winning, and @bryan_johnson for winning the @agingolympics! Comparison and demystification below. Article:
klaustownsend.com/longevity-wo...
Video:
www.youtube.com/watch?v=WERn...
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Longevity World Cup vs Rejuvenation Olympics + Biological Aging Clocks - Klaus Townsend
The inaugural season of the Longevity World Cup (LWC) has officially concluded, and huge congratulations to āØMike Lustgarten for taking first place overall, and Bryan Johnson for his first place in th...
https://klaustownsend.com/longevity-world-cup-vs-rejuvenation-olympics-biological-aging-clocks/
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New YT video!
www.youtube.com/watch?v=JhlZ...
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Beta-Hydroxy-Butyrate: A Key Player In Longevity?
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=JhlZ7SVJek8
4 months ago
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New YT video!
www.youtube.com/watch?v=n4nH...
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TMAO Is Bad For Health, But Can Be Reduced (21-Test Analysis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=n4nHbBN7Fgc
4 months ago
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New YT video!
www.youtube.com/watch?v=viBh...
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Diet Composition that Corresponds To A 15y Younger Biological Age (Blood Test #7 In 2025 Analysis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=viBhSvL9BEs&t=1s
5 months ago
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High HDL? Measure These Liver Biomarkers
youtu.be/9u5qaDC8w_0?...
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High HDL? Measure These Liver Biomarkers
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://youtu.be/9u5qaDC8w_0?si=LoJWiEEtdKamaUYY
5 months ago
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New YT video!
www.youtube.com/watch?v=GUnT...
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S-adenosyl-methionine: A Key Player For Lowering Homocysteine?
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=GUnTeQgsE5U
5 months ago
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New YT video!
www.youtube.com/watch?v=uk9k...
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Cardiovascular Disease Biomarker Deep Dive (Test #7 In 2025)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=uk9k11Zg89w
5 months ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
5 months ago
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
www.cell.com/cell-reports...
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Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
Jin Y. et al. report that physical activity decreases the risks of inflammation-related cancer and cancer-related mortality at least partially by alleviating aging-associated systemic inflammation and...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00557-9
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www.youtube.com/watch?v=DOMm...
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Inside Dr. Michael Lustgartenās Biohacking Self-Experiments | Hundred Studios Episode 4
YouTube video by Hundred Health
https://www.youtube.com/watch?v=DOMmtwVJ6jQ
5 months ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
5 months ago
The antiviral Interferon pathway drives astrocyte aging and motor decline
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.11.12.688147v1
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New YT video!
www.youtube.com/watch?v=cI5H...
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Using Correlations To Improve Biomarkers (Test #7 In 2025)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=cI5HQ7cHpWk&t=1s
5 months ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
6 months ago
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
www.jstage.jst.go.jp/article/bst/...
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The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
Inflammatory bowel disease (IBD) and physiological gut aging present with overlapping clinical features, including impaired barrier functioning, decre ā¦
https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_2025.01279/_article
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reposted by
Michael Lustgarten, PhD
Aging Science News
6 months ago
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
www.cell.com/cell-stem-ce...
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Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif et al. show that lysosomes in aged HSCs are hyperacidic and dysfunctional, and that lysosomal alterations are central to HSCsā decline with age. cGAS-STING signaling, driven by misprocessed mtDNA...
https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00405-9?rss=yes&utm_medium=twitter&utm_source=dlvr.it
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New video!
www.youtube.com/watch?v=-MTm...
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Who's Really Winning At Longevity? (Featuring @Unaging.Crissman.Loomis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=-MTmYomgmes
6 months ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
6 months ago
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
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Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue m...
https://onlinelibrary.wiley.com/doi/10.1111/acel.70294
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reposted by
Michael Lustgarten, PhD
Eric Topol
6 months ago
How a mattress sensor and smartwatch confirmation led to a patient's diagnosis of complete heart block and need for a pacemaker
@nejm.org
www.nejm.org/doi/full/10....
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New video!
www.youtube.com/watch?v=qKAj...
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If We Escape Age-Related Disease, Motor Unit Loss Will Shorten Lifespan
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=qKAjIbAzo5E&t=1s
6 months ago
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New YT video!
www.youtube.com/watch?v=poEP...
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If We Escape All Major Diseases, Neurodegeneration And Respiratory Failure Is Likely
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=poEP7cQBCn4
6 months ago
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reposted by
Michael Lustgarten, PhD
Conor Browne
6 months ago
As I've said before, the distinction drawn between acute infectious diseases and chronic diseases is, in many cases, artificial. This is the huge flaw in MAHA: infections can and often do cause chronic disease; vaccines can thus prevent some chronic diseases.
stanmed.stanford.edu/infections-l...
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Why acute infections can lead to neurodegeneration
Researchers are uncovering the mysteries of why early-in-life acute infections can lead to neurodegenerative diseases in later years.
https://stanmed.stanford.edu/infections-link-later-life-neurodegeneration/
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www.youtube.com/watch?v=yNbX...
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Carotenoids Are Associated With A Younger Biological Age
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=yNbXCzQB8hY
6 months ago
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Ner YT video!
www.youtube.com/watch?v=0zPc...
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The Waist-To-Hip RatioModifies LP(a)-Associated CVD Risk
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=0zPcCocwI5o
6 months ago
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New YouTube video!
www.youtube.com/watch?v=1N1w...
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Glucagon Signaling Is Required For The Lifespan Extending Effect Of Calorie Restriction
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=1N1wI1tTzwI
6 months ago
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New YT video!
www.youtube.com/watch?v=bUh7...
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Diet Composition That Corresponds To A 17y Younger Biological Age (Test #6 In 2025 Deep Dive)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=bUh7icfos-E
6 months ago
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New YT video!
www.youtube.com/watch?v=hrVE...
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Optimizing Vitamin D, NAD, Homocysteine (Test #6 In 2025 Analysis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
https://www.youtube.com/watch?v=hrVEWDySqA4
7 months ago
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Tracking Every Biomarker: Inside Dr. Lustgartenās Data-Driven Blueprint for Longevity
youtube.com/watch?v=agwn...
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http://youtube.com/watch?v=agwnE_Z6edk
7 months ago
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reposted by
Michael Lustgarten, PhD
Aging Science News
7 months ago
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice
link.springer.com/article/10.1...
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Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice - GeroScience
Obesity and type 2 diabetes mellitus accelerate aging, shortening the duration of healthspan. Conversely, chronic calorie restriction (CR) extends healthspan. Research aimed at understanding the mecha...
https://link.springer.com/article/10.1007/s11357-025-01899-w
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