Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵

Big congrats to Marishka on this. I know how much time and effort went into it. Really happy to see it out! For those interested, she replicated prior longitudinal results using an approach-avoidance conflict task and showed how model parameters afforded out-of-sample clinical prediction.

Agreed. The video examples are super interesting. I wish the questions were asked in a more controlled way, but I can’t fault for some limitations of this rarely possible type of work. It seemed quite somatic and abrupt. No spontaneous descriptions of emotion proper either. Only when given a word.

Computational modeling revealed that individuals with methamphetamine use disorder show reduced information-seeking and slower belief updating when trying to maximize long-term reward. @torutakahashi.bsky.social @rssmith.bsky.social www.nature.com/articles/s44...

Congratulations to @torutakahashi.bsky.social and Carter Goldman on their newly published paper! This paper shows that individuals with methamphetamine use disorder show reduced directed exploration and slower dynamic learning rates in both high/low anxiety states www.nature.com/articles/s44...

I am so excited to share that our paper 'A neural basis for distinguishing imagination from reality' is now published in @cp-neuron.bsky.social! 🧠✨ See thread below! doi.org/10.1016/j.ne...

this is excellent - congratulations! In particular nice to see the very robust basic pruning behavioural effect replicate in this version of the task (originally designed for the scanner). It seems that pruning may end up being more relevant to SUD than MDD, @docqhuys.bsky.social!

Thank you @clairelavalley.bsky.social and @rssmith.bsky.social. Striking to see aversive pruning altered in people with methamphetamine use, particularly given the results in depression (dx.doi.org/10.1017/S003...).

Huge congrats to @clairelavalley.bsky.social on this new paper. www.nature.com/articles/s41.... Results show that methamphetamine users show a specific deficit in model-based planning, in which they fail to simulate plans with large short-term losses (elevated aversive pruning). Brief thread below!

Congratulations to co-first author @clairelavalley.bsky.social on validating this new performance-based measure of social emotion regulation ability: emotionandpsychopathology.org/journal/arti... In psychopathology, this may be crucial for maintaining social support. We hope others find it useful!

Very excited to congratulate Ning Li and @clairelavalley.bsky.social on their new paper published in Molecular Psychiatry. "Directed exploration is reduced by an aversive interoceptive state induction in healthy individuals but not in those with affective disorders" (nature.com/articles/s41...) 🧵👇

Out today in PNAS! We asked how Bayesian inference is implemented in macaque prefrontal cortex www.pnas.org/doi/10.1073/...

Reinforcement Learning and Active Inference are two frameworks used in computational psychiatry, but these are rarely directly compared empirically. In this new article, we aimed to compare these in a more systematic manner by fitting each to multiple datasets: papers.ssrn.com/sol3/papers....

I'm excited to attend the #ECNP Workshop on Applied Neuroscience and present our findings on markers of abnormal gastrointestinal interoception predicting relapse in anorexia nervosa. Catch Poster P107 on Thursday, March 20, & my oral presentation on Friday, March 21, at 9:10 AM

Congrats to Marishka Mehta on her new chapter! She did a great job summarizing the current state of the field and important future directions. link.springer.com/chapter/10.1... "Computational Approaches for Uncovering Interoceptive Mechanisms in Psychiatric Disorders and Their Biological Basis"

Excited to congratulate Marishka Mehta on her new preprint (www.medrxiv.org/content/10.1...) combining modeling, machine learning, and longitudinal clinical data. "Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders"

@rssmith.bsky.social and I are working on a symposium proposal on interoceptive and embodied computational psychiatry for this - do let us know if you would like to join as we have open slots. Focus is on quantification and intervention.

Poster submissions for the Computational Psychiatry Conference 2025 in Tübingen are now open. Deadline is 7th February. Symposium submissions are open until 15th January. www.cpconf.org. Please RB.

I could not find a body representation starter pack so I made one! Please message if you want to join. I know I missed excellent scientists, philosophers and clinicians out there go.bsky.app/EAmckAo

Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons. Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)

Just switching over to Bluesky now. Looking forward to good discussions and finding out about new papers again!