We are hiring! Looking for curious and motivated new colleagues to join my lab at the Karolinska Institute @ki.se. If you are interested in studying cell identity and pancreas biology using human organoids, (spatial)omics genome and bioengineering please reach out! #hiring #sciencejob #STEMJobs

Big congrats Robin! So well deserved ☺️ Looking forward to our collabs

1/ 🧬 Very excited to share our work on dissecting imputation strategies for single-cell histone modification data! academic.oup.com/nargab/artic... A huge thank you to @robinhweide.bsky.social, @jopkind.bsky.social and Jeroen de Ridder for their collaboration in this project!

Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction. With @hansclevers.bsky.social. Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social www.biorxiv.org/content/10.6...

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

Great place for a PhD with one of the smartest minds in the field!

Great PhD opportunity with a fantastic mentor!

1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

Finally out on @devbiol.bsky.social‬: we find that Epop mutant mice have near-perfect Polycomb phenotype (orderly posterior shift of vertebral identity🩻) linked to accelerated HOX clock⏰. Bonus: Epop has maternal effect! Study co-led by the the labs of Bernie Payer and @lucianodicroce.bsky.social

Great use of DamID to use it as a history tracing tool!

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

Great new paper from the lab highlighting the utility of multimodal single-cell readouts!

🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰). Come work in our collaberative team of top scientists shorturl.at/avBBy

🚨 Paper Alert 🚨 I'm incredibly proud and excited to announce that our latest research on the chromatin regulatory profile of gastruloids has been published in @DevCell! 🎉 Check out the full paper here: www.cell.com/developmenta... @dewitlab.bsky.social , @bracciolilab.bsky.social 🙌 🧵👇

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

A new review from our group on the implementation of single-cell epigenomics in cancer research. A hitchhiker's guide for the use of both wet- & drylab methods. A big shout-out to Marta and Isabel! doi.org/10.1002/ijc....

📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/... Big thanks to Hendrik Marks for taking the lead this time!

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...

Very excited to see our work on genome-wide mapping DNA repair in single cells out @naturecomms.bsky.social Amazing work by Kim de Luca & Pim Rullens. Wonderful collaboration with the Legube lab, @mariekeoudelaar.bsky.social & @jjachowicz.bsky.social . rdcu.be/d0ZAM