Reza G
@m-rezagh.bsky.social
📤 34
📥 73
📝 5
Electrophysiologist, biomedical researcher, and a bunch of other things @YaleMed
Our new paper is out in Neurology Genetics: Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain.
www.neurology.org/doi/10.1212/...
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Nav1.8 Variant I206M as a Latent Susceptibility Factor in Postaxotomy Ocular Pain | Neurology Genetics
Background and ObjectivesA small proportion of patients develop persistent ocular pain after corneal refractive surgery, which injures the distal axons of trigeminal ganglia neurons innervating the ey...
https://www.neurology.org/doi/10.1212/NXG.0000000000200367
about 1 month ago
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Excited to share our new paper in
@jphysiol.bsky.social
: Matching sodium channel availability to resting membrane potential: Biophysical logic across excitable cell types.
physoc.onlinelibrary.wiley.com/doi/10.1113/...
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Matching sodium channel availability to resting membrane potential: Biophysical logic across excitable cell types
Abstract figure legend Matching sodium channel availability to resting membrane potential defines excitable cell function. Top, schematic summary illustrating how the relative alignment between Nav c...
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP290383
about 1 month ago
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4
2
reposted by
Reza G
Nature Protocols
11 months ago
New Article! High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons
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High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons
Nature Protocols, Published online: 13 June 2025; doi:10.1038/s41596-025-01194-0This Protocol describes an automated high-throughput patch-clamp approach that enables the simultaneous and unbiased analysis of acutely dissociated neurons in their native state, with diverse applications ranging from the assessment of neuronal biophysics to drug development.
https://bit.ly/4jQ7CRw
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Pleased to share this new paper:
www.frontiersin.org/journals/psy...
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Frontiers | Brain stimulation enhances dispositional mindfulness in PTSD: an exploratory sham-controlled rTMS trial
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1494567/full
about 1 year ago
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Pleased to share our new paper:
www.sciencedirect.com/science/arti...
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In Vitro Inhibition of Voltage-Dependent Sodium Currents by the Antifungal Drug Amorolfine
Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development o…
https://www.sciencedirect.com/science/article/pii/S002192582500256X?via%3Dihub
about 1 year ago
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Our new study: Targeted
#ubiquitination
of
#NaV1.8
reduces sensory neuronal excitability.
#pain
@yale.edu
www.biorxiv.org/content/10.1...
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Targeted ubiquitination of NaV1.8 reduces sensory neuronal excitability
Chronic pain and addiction are a significant global health challenge. Voltage-gated sodium channel NaV1.8, a pivotal driver of pain signaling, is a clinically validated target for the development of n...
https://www.biorxiv.org/content/10.1101/2025.02.04.636451v1
over 1 year ago
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reposted by
Reza G
Leah Mayo
over 1 year ago
The first
@pact-lab.bsky.social
paper of 2025 is out now in
@npp-journal.bsky.social
🤩 Led by
@madeleinejones.bsky.social
&
@connorhaggarty.bsky.social
ft.
@abby-lunge.bsky.social
@cannabrain.bsky.social
& others
www.nature.com/articles/s41...
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Endocannabinoid contributions to the perception of socially relevant, affective touch in humans - Neuropsychopharmacology
Neuropsychopharmacology - Endocannabinoid contributions to the perception of socially relevant, affective touch in humans
https://www.nature.com/articles/s41386-025-02053-y
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reposted by
Reza G
Ted Price
over 1 year ago
BOOM! Big advance in our understanding of the pharmacology of CBD, CBN, and most importantly CBG. New work from the Waxman lab showing these "minor" cannabinoids act on Nav1.8:
www.pnas.org/doi/10.1073/...
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https://www.pnas.org/doi/10.1073/pnas.2416886122
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