Congratulations to Dr. Paula Arya, Dr. Joaquin Espinosa and Dr. Kelly Sullivan for leading a new study published in iScience entitled "Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model." Read more at https://bit.ly/3Io31cK.

As Postdoc Appreciation Week ends, we celebrate our three outstanding postdocs at the Crnic Institute. Thank you, Dr. Brian Niemeyer, Dr. Sara Sherman and Dr. Ariel Timkovich, for your invaluable contributions. Our mission to advance Down syndrome research wouldn’t be possible without you!

We need research heroes! Researchers at the Crnic Institute and Boys Town National Research Hospital are working together to better understand hearing and balance in people with Down syndrome from September 8-13 at Children's Hospital Colorado. Learn more: bit.ly/HearinginDS

Registration is open for the annual Crnic Institute Down Syndrome Research Symposium on September 15, 2025! This in-person event will take place on the 2nd floor of the Anschutz Health Sciences Building. Register today at https://bit.ly/DS-Symposium.

Congratulations to Dr. Kelly Sullivan, director of the Crnic Institute’s Experimental Models Program and associate professor at @cupediatrics.bsky.social‬, on presenting ”The Interferonopathy of Down Syndrome,” and to Rachel Shropshire for winning Top Student Poster at this year’s DSMIG Symposium!

The 2026 Program will heavily emphasize co-occurring conditions and tissue systems affected by T21. We encourage diversity in the composition of symposia speakers with respect to geography, academic rank, and gender. Society members at all career stages are welcome to submit symposia.

The theme for the 6th International Conference of the Trisomy 21 Research Society will be, “T21: Insights from Across the Lifespan”. Each symposium will consist of four speakers in a 2-hour block and should include both basic and translational components to foster discussion among research teams.

Planning for next years T21RS International Conference in Denver is under way! Call for Symposia will open on August 15. If you have any questions, please don't hesitate to reach out. www.t21rs.org/5th-t21rs-in...

Are you bravely deciding to do a postdoc in the US? And also interested in some combination of genomics, immunology, and transposons? If so, consider applying to my lab at the BioFrontiers Institute in Boulder, Colorado! jobs.colorado.edu/jobs/JobDeta... 🧪🧬 #TESky #interferosky

New research opportunity! Researchers at the Crnic Institute and Boys Town National Research Hospital are working together in Dallas, TX, to better understand hearing and balance in people with Down syndrome. Compensation is provided. Learn more and schedule an appointment at bit.ly/HearinginDS.

Some news....Rome is not fully burned down. T32 PhD Training Grant was officially awarded, and two weeks ago, the NIH offered more support than requested to increase the # trainees in the unique program. Office chair with me in it levitated. Calling Microbime PhD'ers to @psumbiome.bsky.social 🎓

NIH and FDA hosted a workshop on July 7 on efforts to reduce the use of animal models in research, NIH has formally announced a policy change. The agencies have invited comments through the workshop’s webpage. PLEASE COMMENT. The portal will be open until 5pm ET on Monday, July 14 (TODAY).

Congratulations to Dr. Jason Wilson of @cuhmggp.bsky.social on successfully defending his dissertation yesterday! You can check out some of his work here: www.biorxiv.org/content/10.1...

Grateful to meet with students from CU Boulder’s CU in DC program. Appreciated their thoughtful and insightful questions!

Delighted to share our updated work, led by postdoctoral fellow Dr. Maria Campaña, published in @natcomms.nature.com: rdcu.be/em66g, PDGFRalpha/beta heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

Maybe someone needs to say this out loud, but computers can't model the physiology of a living organism because we don't know how many of the parts of an organism work, which is uhhh... why we do the research with the animal models?

ICYMI - “This is life and death stuff for Americans and for Coloradans.” – Rep. Jason Crow sentinelcolorado.com/metro/trump-... #TrumpCuts #COpolitics #DOGE

Thank you Congressman @crow.house.gov for visiting the #CUAnschutz Medical Campus to learn more about our latest breakthroughs and the vital role of federal funding in driving lifesaving new medical discoveries.

It was a pleasure to have Kristina Sisneros from Regis University for her GLOBAL Inclusive Program Internship! Thank you to GLOBAL for supporting this amazing opportunity, and congratulations to Kristina on all her hard work.

Wow.

Hi Folks! Myself and the Barberan Lab at U of A are still looking for a PhD student to work on an NSF funded project exploring effects of fire and invasion on soil microbes. We are looking for someone to start in Fall! SOON! Email me if you are interested! PLS Repost! @EsaSeeds

striking to me that this interview ends with him plaintively pleading for other university leaders to speak up: "I don’t think this is all about Princeton. It’s about what’s happening in the United States. I think this would be so much stronger if many more of my fellow presidents were speaking up."

Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n

Are you wearing different socks to celebrate #WorldDownSyndromeDay ? Join in!!! It's fun!!!

Was very excited to host Senator Hickenlooper in my lab this past week, as well as be involved in a panel discussion around the important of federal funding for science! coloradosun.com/2025/03/19/n...

Tomorrow is World Down Syndrome Day (3/21)! We have made great strides in understanding Down syndrome and improving healthspan for this amazing community, but there is much work to be done. Honored to be part of the Trisomy 21 Research Society Executive Board. www.thelancet.com/journals/lan...

Be part of research progress! Our researchers are working with @boystownhospital.bsky.social to learn more on balance and hearing in #Downsyndrome. This single appointment includes balance exercises and a hearing test with results given on site. Learn more: bit.ly/3R4Ogwl

Join us this Wednesday, March 19th, for our monthly Supergroup presentations! This event is open to all Crnic Institute Members. If you are not a member and are interested in data science presentations, visit bit.ly/CrnicMember. @caylajewett.bsky.social

Tough loss. Good to see them fight back again.

Ugh. Glad they made it a game at least.

One of our stars defended today! Dr. @luulitran.bsky.social from the @thefrancolab.bsky.social lab gave a stellar seminar describing her deep, insightful, and highly productive investigations of the neuron-glia switch. #devbio @cupediatrics.bsky.social @cuanschutz.bsky.social

We need to research heroes! Our researchers are partnering with researchers at Boystown National Hospital from April 12-18 in Boston, MA, to better understand hearing and balance in #Downsyndrome. This study is a single appointment, including a hearing test and biological sample. bit.ly/3R4Ogwl

#DYK as many as 9 in 10 people with Down syndrome develop Alzheimer’s disease? If you or a loved one is healthy & between the ages of 25-55 with Down syndrome, visit trcds.org.

Excited to post this op-ed published in the front porch and written by the talented Aimee Bernard in conjunction with the basic science chairs. Opinions are our own. frontporchne.com/opinion-the-...

Members of the Human Trisome Project - Latin America Network (HTP-LAN) team recently traveled to Colorado for a week of collaboration and education! We are proud of our team for gaining valuable skills to support Down syndrome research procedures across the network.

A new publication from the Crnic Institute team in collaboration with Dr. Jonathan Santoro at Children's Hospital Los Angeles (CHLA) reveals new insights about the molecular and immune changes associated with Down Syndrome Regression Disorder (DSRD). bit.ly/4iawGSS

We are hiring! Looking for a Research Assistant to join our group at CU Anschutz in Denver studying genome integrity nguyenlab.org. Individuals will lead their own project as well as help support basic lab function! cu.taleo.net/careersectio...

“It’s really an elaborate infrastructure that’s required to do this research. One of the things that concerns me is the magnitude and rapidity of these changes.” VC for Research Tom Flaig, MD, recently spoke to @cbsnews.com about the potential impact the proposed NIH cuts could have on our campus.

Very proud to be a member of this team. A huge group effort to improve the lives of those with Down syndrome. Thank you to everyone that has helped us along the way.

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs… “I think they're being short-sighted, because fear does that to you.”

Kids will suffer because of this. This is an outrage.

Attention Attention Attention If anyone knows clinicians or patients who have knowledge of pediatric patients with the very rare cancer interdigitating dendritic cell sarcoma (IDCS) or other (non-LCH) dendritic or histiocytoc sarcomas please contact Sri

Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

‘Big data’ generated from outsourced or centralized facilities often lacks methodological information. This Perspective outlines how and why researchers, service providers, and other parties should report on #methodology and sample #metadata to improve scientific #reproducibility. plos.io/42hSck6

Our first manuscript on maternal nutrition and development, which was driven entirely by postdoc Katie Ranard, is now out. @cudevbio.bsky.social #devbio doi.org/10.1016/j.jl...

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

Meet the author: Dr. Katie Ranard, a NINDS F32-funded postdoc in the Appel lab, just published her first manuscript describing use of zebrafish to model the impact of maternal nutritional deficiency on brain develepment. doi.org/10.1016/j.jl... 🧪🧠 #zebrafish #devbio

#InterferonPower! Fantastic @science.org by @nandangokhale.bsky.social @ramlabuw.bsky.social &co! MAVS is intrinsically capable to sense via an unstructured region the 3’ UTRs of self mRNA (ISGs too!) to potentiate the response to viral RNA via phosphorylation of IRF3 & NFkB!

This is super cool.