Fantastic talk by @goico13.bsky.social at today’s Science Bites on targeting the dark epigenome to activate anti-tumour responses. @icr.ac.uk @breastcancernow.bsky.social

Viral infections can wake up dormant breast cancer cells in the lung, driving metastasis www.nature.com/articles/s41...

ADAR1 loss in BRCA1/2 drives R-loop buildup and lethal IFN signaling www.nature.com/articles/s41...

Exciting new paper in Cancer Discovery: ecDNA drives spatial tumor evolution aacrjournals.org/cancerdiscov...

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA. www.cell.com/cell/fulltex...

#GlycoPower! @vijayrathinam.bsky.social @raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!

Thrilled to present my research at the 2024-25 Annual ICR Conference! And deeply grateful to receive an Oral Presentation prize! Huge thanks to the whole @meierlabicr.bsky.social, organizers, and brilliant colleagues for the inspiration. Onward! 🚀 #ICR2025 #Research #Science

SP140 lowers IFN-β by switching off RESIST (a newly found mRNA stabilizer) and stalls gamma-herpesvirus. Dual antiviral punch! www.nature.com/articles/s41...

Just out in Nature Comms! Palbociclib in combination with virotherapy amplify ER stress and immune activation. www.nature.com/articles/s41...

Cancer cells transfer mitochondria with mutated mtDNA to tumor-infiltrating T cells, impairing their function and promoting immune escape. Awesome work! www.nature.com/articles/s41...

Delivery of cytosolic bacterial pathogens elicits anti-tumor responses via actiavtion of TLR pathway. www.sciencedirect.com/science/arti...

Exonization of transposons leads to the formation of new protein-coding sequences, potentially impacting immune regulatory pathways. www.cell.com/molecular-ce...

Chromosome missegration activates dsRNA-sensing pathway in a MAVS-dependent manner and enhances innate immune signaling! www.cell.com/molecular-ce...

A new study in @cellpress.bsky.social Immunity from the lab of Dr. Benjamin Greenbaum provides insights into how #PancreaticCancer cells accommodate active retrotransposons without triggering the innate immune response. #oncsky #medsky

Insights by Erika Valeri and @kajastelab.bsky.social: Two works by Chan et al. (https://buff.ly/3D66PfJ) and Ru et al. (https://buff.ly/49or5Fo) identify defective RNA processing as the root cause of impaired antiviral immunity against #SARSCoV2 in the human brainstem: https://buff.ly/4g74MXy

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...

Blocking IRE1α enables RNA accumulation, triggering ZBP1-driven cell death and making cold TNBC tumors ICI-sensitive! www.cell.com/cell/fulltex...