Stephan Wilmes
@stephanwilmes.bsky.social
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PhD student in Kümmel-Lab @ University of Münster
Thrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core.
www.science.org/doi/full/10....
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Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.
https://www.science.org/doi/full/10.1126/sciadv.adx2893
22 days ago
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reposted by
Stephan Wilmes
Jan-Hannes Schaefer
about 2 months ago
Check out our new preprint from the
@landerlab.bsky.social
, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection
www.biorxiv.org/content/10.1...
Happy testing:
cryosift.org
#cryoEM
#CNN
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Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out!
doi.org/10.1101/2025...
Thanks to everyone involved!
@jessetoenjes.bsky.social
@jhschaef.bsky.social
@djanuliene.bsky.social
@arnemoeller.bsky.social
@nartimsoole.bsky.social
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Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelit...
https://doi.org/10.1101/2025.03.27.645700
6 months ago
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reposted by
Stephan Wilmes
bioRxivpreprint
6 months ago
Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
https://www.biorxiv.org/content/10.1101/2025.03.27.645700v1
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reposted by
Stephan Wilmes
bioRxiv Biochemistry
10 months ago
Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
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Structure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
The RalGAP (GTPase activating protein) complexes are negative regulators of the Ral GTPases and thus
https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1
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