🧪 Filoviruses are among the most lethal viruses known to infect humans. Yet despite decades of research, major questions about their ecology, evolution, host range, and potential for wider geographic spread remain unresolved. ➡️A thread on Ebola, Marburg, and related filoviruses.

Ein Medikament gegen alle Viren: Ist das möglich? Stefan Pöhlmann (@snpoehlm.bsky.social) von @primatenzentrum.bsky.social & @uni-goettingen.de im #Podcast #TonspurWissen von @leibniz-gemeinschaft.de & Rheinischer Post. 💉 👉 pod.fo/e/41ba7b #Medizin #Viren #Impfung #Ebola #Hanta #Infektionen

A cathepsin L inhibitor active against coronaviruses in cell culture and against the coronavirus MHV-1 in a rodent model. rdcu.be/fih6u

Repurposing clinical candidates against Nipah virus and Hendra virus ▶️Cathepsin L inhibitors showed potent antiviral activity in cell culture, including the clinical-stage inhibitor relacatib.

Furin Inhibition Protects Against Acute Lung Injury in a Mouse Model of Pseudomonas Aeruginosa Infection academic.oup.com/ajrcmb/artic...

Furin as target for suppression of mosquito-borne viruses ➡️Furin encoding genes identified in mosquito cell lines. ➡️A furin inhibitor blocked Semliki Forest virus infection of mosquito cell lines. Centurión et al. Virol J 11;23(1):92. 2026 Mar rdcu.be/fhn4j

Should You Worry About Hantavirus? www.nytimes.com/2026/05/06/w...

Three suspected #hantavirus case patients have just been evacuated from the ship and are on their way to receive medical care in the Netherlands in coordination with @who.int, the ship’s operator and national authorities from Cabo Verde, the United Kingdom, Spain and the Netherlands. (1/4)

Hantaviruses are rodent-borne pathogens that can cause severe disease in humans. Andes virus, found in South America, is the only hantavirus known to occasionally spread between people, typically after close contact.

Interesting study by Li and colleagues: Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious viral disease of pigs caused by a virus - PRRSV. 1/4

I'm very proud to share new work reporting a lipid scrambling activity and pathway within the Sec61 protein translocon. pubs.acs.org/doi/10.1021/...

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

SND3 is the membrane insertase within a distinct SEC61 translocon complex www.nature.com/articles/s41...

Platelet hyperactivity in type 2 diabetes increases the risk for blood clots. Freda H. Passam & team now identify SEC61 as an ER calcium leak channel in platelets—upregulation of which contributes to platelet hyperreactivity in diabetes: bit.ly/3HEC97P

The early bird catches the flight ✈️🐦 The Marburg UMR travel group made it onto the early morning plane to Ljubljana — even with the Lufthansa strike going on. Looking forward to an exciting @vigilant-eu.bsky.social meeting.

VIGILANT annual meeting in Ljubljana New findings, great discussions, and valuable input from our Scientific Advisory Board. Projects are advancing, collaborations strengthening, and progress toward broad-spectrum antivirals continues. Thanks to all involved - and to the European Union for funding

Just over three weeks until our annual meeting, with talks by renowned experts open to the public. The talks will be available in person and online on the day. Virologists in Ljubljana, be sure to drop by! We are looking forward to sharing our knowledge with you!

VIGILANT will be holding its 2026 Annual Meeting in Ljubljana in April. Our keynote speeches are open to the public across two sessions on the Friday. We are looking forward to seeing members virology community in Slovenia in full force!

Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses rdcu.be/e7RMY

Structural basis of Nipah virus RNA synthesis rdcu.be/e7RLC

A much-needed vaccine for Nipah virus www.nature.com/articles/d41...

www.theguardian.com/science/2026... The recent Nipah virus outbreak is a stark reminder of how quickly zoonotic viruses can emerge & spread. VIGILANT is tackling this threat head-on by developing medical compounds that target host cell pathways hijacked by Nipah and related viruses. ...

What is Nipah virus? Key things to know about the disease amid cases in India

MEET THE VIGILANT TEAM We are interviewing Project VIGILANT staff to introduce them to you! Ville Paavilainen Research Director - Chemical Biology & Proteostasis Research Group, Institute of Biotechnology, University of Helsinki - www.helsinki.fi/en/researchgroups/proteostasis-and-chemical-biology

I've got a bad feeling about the upcoming flu season, given the fact that there are a bunch of subtypes at this party with the potential to wreak varying amounts of havoc. So I broke it all down here. open.substack.com/pub/rasmusse...

This is an interesting case of a patient from Chad infected with a novel arenavirus species/variant/strain, presenting with meningoencephalitis. IMO, could be classified as a highly divergent Lassa virus strain in a new country (similar to what Togo has observed). www.nejm.org/doi/10.1056/...

Ethiopia confirms its first-ever Marburg virus outbreak in the South Ethiopia region. Rapid response activated - hoping for swift containment. Marburg has no approved vaccine or specific treatment. Broad-spectrum antivirals are a critical unmet need to save lives and stop outbreaks faster.

Proud that Markus Hoffmann and I made the 2025 Clarivate Highly Cited Researchers list. Huge thanks to everyone in the Infection Biology Unit at the German Primate Center - honoured and grateful. @primatenzentrum.bsky.social clarivate.com/highly-cited...

Thank you for hosting this excellent symposium!

New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development. www.science.org/doi/10.1126/... @unmc.bsky.social @uwbiochem.bsky.social

🔬🌍 On #WorldScienceDay, we focus on trust, transformation, and the science we need for 2050. Transparency builds trust, open and collaborative research drives change, and safeguarding academic freedom shapes tomorrow. Let’s reflect on the science we choose to build. #ScienceFor2050

Exciting advancements in research for pandemic preparedness from EU-funded consortia, with substantial opportunities for interdisciplinary collaboration. #HorizonEurope

MEET THE VIGILANT TEAM We are interviewing the staff at Project Vigilant to introduce them to you! Meet Gerald McInerney Professor of Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute

VIGILANT theme highlighted by Stefan Pöhlmann at the 11th European Meeting on Viral Zoonoses (Saint-Raphaël, Sept 20–23, 2025). Focus: how Sec61 targeting disrupts filovirus glycoprotein function and infectivity. #ViralZoonoses #EMVZ #SaintRaphael

MEET THE VIGILANT TEAM We are interviewing the staff at Project Vigilant to introduce them to you! Meet Andrea Marzi Chief of the Immunobiology & Molecular Virology Section, Laboratory of Virology, DIR, NIAID National Institutes of Health Rocky Mountain Laboratories

climate change - it's a thing. and it affects more than just the climate and weather www.science.org/content/arti...

Ebola poses a serious global threat. We hope for swift containment and are committed to research for future prevention.

1/ The protease furin activates dangerous viruses like H5N1. But since it has many close relatives, specifically targeting furin is a huge challenge. #Virology #DrugDiscovery

MEET THE VIGILANT TEAM We are interviewing the staff at Project Vigilant to introduce them to you! Meet Wolfgang Knecht Director of the Lund Protein Production Platform (LP3, www.lp3.lu.se), Deputy Director of Protein Production Sweden (PPS, www.pps.gu.se/en) and Group Leader of SciLifeLab.

🚨VIGILANT is developing antivirals that block cellular factors viruses depend on - proteases and Sec61. This thread 🧵 explains why cellular proteases are attractive targets to stop viruses before they spread. 🦠🔒

MEET THE VIGILANT TEAM We are interviewing the staff at Project Vigilant to introduce them to you! Meet Stefan Pöhlmann Head of the Infection Biology Unit @ German Primate Centre.

📢 Registration is OPEN for the 2025 edition of the European Research and Innovation Days #RiDaysEU! 📅 Join the ERC on 17 Sept for the session "Securing Europe’s place at the forefront of scientific discovery" 🔗 Register now 👉 t.co/nPQmG6ix1G for access & more info. www.youtube.com/watch?v=o50Y...

NSV 2025 – outstanding science, thought-provoking discussions, new input for VIGILANT, and a great location. #NSV2025

🔬🦠 VIGILANT partner @snpoehlm will present our research on filovirus activation by host cell proteases at #NSV2025 in Montpellier, June 22–27. Catch us there! #Virology #NSV2025

Next generation of infection biologists at the Nacht des Wissens #ndwgoe @uni-goettingen.de

VIGILANT public outreach at the Night of Science in Göttingen — sharing perspectives on broad-spectrum antivirals and pandemic preparedness. Thanks to all who stopped by and joined the conversation! #VIGILANT #snpoehlm #NightOfScience #Göttingen

VIGILANT partners Eva Böttcher-Friebertshäuser and Torsten Steinmetzer will be hosting an online virology conference this week: “Nucleophilic Proteases: Structure, Function, Regulation, and Disease” - www.asbmb.org/meetings-events/nucleophilic-proteases Registrations close 18th June. See you there!