Our story on plasmid streamlining is now published in PLoS Biology! With @andrewmatthews.bsky.social and @sonjalehtinen.bsky.social #MicroSky #Mevosky journals.plos.org/plosbiology/...

Interested in MGE-host coevolution? Like sunny #Porto? Apply to #LaCaixa doctoral #INPhINIT fellowships with me and explore the hidden world of mobile genetic elements🧬 DM or email in case of interest. Please RT! lacaixafoundation.org/en/doctoral-... #MicroSky

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8

Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky journals.plos.org/plosbiology/...

PhD studentship opportunity! Join us at St Andrews to study the factors controlling plasmid transmission in the gut. Competition-funded as part of the EASTBIO DTP, co-supervised with Dr Jaclyn Pearson. Please share & pass on to anyone interested! 🦠🧫 Deadline 15th December👇

🚨#PhD studentship opportunity! Plasmids provide bacteria with antimicrobial resistance, but do they have more fundamental effects on behaviour? 🧫🦠💫🧟‍♂️ Apply for a 4y funded MRC DiMeN position with me and Jamie Wheeler @livuni-ives.bsky.social www.findaphd.com/phds/project...

Finally out from @daganlab.bsky.social! 🌱🦠🧬 Evolution of the Plant-Associated Pantoea was Accompanied by Plasmid Domestication Events url: academic.oup.com/mbe/article/...

🚨New preprint out! We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8) www.biorxiv.org/content/10.1...

We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place.

📣 PhD opportunity led by @madhvimenon.bsky.social with @kathelse.bsky.social , @tracyh9494.bsky.social , and me open now: "Sex Differences in Immune Responses to Infection: The Role of the Microbiota in Shaping Lymphocyte Dynamics" apps due 15 November 2025 📣 www.findaphd.com/phds/project...

Is a healthy microbiome one that is rich in phages? 🦠 Excited to share our paper out in Lancet Microbe with @bkoskella.bsky.social & @dholtappels.bsky.social where we test whether virome diversity can be used a broad signature of microbiome health 📈

Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics We just did that to study the history of #AMR spread @science.org doi.org/10.1126/scie... If you like time travel & biology, this 🧵is for you👇

OK, here it is. Come work with me at the University of Liverpool making ALL THE AI models from ALL THE prokaryote pangenome data. Heck, we will make models from ALL the pangenomes, even eukaryotes!!! (link below👇) 1/4

Incredibly proud to be named one of the World’s Top 2% Scientists for 2025 by Stanford/Elsevier, alongside my brilliant colleagues from CBQF at UCP! cbqf.esb.ucp.pt/news/eight-c...

Exclusion systems preserve host cell homeostasis and fitness, ensuring successful dissemination of conjugative plasmids and associated resistance genes url: academic.oup.com/nar/article/...

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you www.jobbnorge.no/en/available...

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription. www.cell.com/cell/fulltex... Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

The preprint of my first article is available on bioRxiv! We use a transposon ecology framework to analyze the distribution of insertion sequences within prokaryotic genomes. We characterize their ecological niche and show evidence of niche construction 🧪🧬💻 www.biorxiv.org/content/10.1...

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins Structural predictions to improve #phage genome annotation! @hannelorelongin.bsky.social @gbouras13.bsky.social y.social @susiegriggo.bsky.social @veravannoort.bsky.social www.biorxiv.org/content/10.1...

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

And the story is published now!🍾 www.nature.com/articles/s41... Open access link: rdcu.be/exnOc Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏 #microsky #archaeasky

🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

🚨 Reminder! You have just over two weeks to submit an abstract, if you want to present at the @microbiologysociety.org meeting "Understanding and predicting microbial evolutionary dynamics" in Liverpool in November! #microsky 🦠🧫🔬

Thank you to everyone who attended the 3rd UK MGE workshop. What an incredible few days of science and community building! Next stop: York 2026, hosted by @pcmfogg.bsky.social. See you all next year! #UKMGE

Defence Systems are so hot right now 🔥 🔥 🔥 so check out our latest preprint to see how DSes contribute to niche adaptation, interact with each other, and drive accessory genome interactions in Pseudomonas aeruginosa 1/n www.biorxiv.org/content/10.1...

We still have space for additional attendees, and we encourage you to share this invitation within your networks so others can benefit from the fantastic panel we have assembled for this edition. Better program than your favourite paid conference - just saying 😉

The program for the 3rd MGE Workshop is now live! Check out this year's speakers using the link below. The deadline for registration closes on Friday 30th May ⏰ We look forward to seeing you all in Southampton in a few weeks time! #MGE #MGEWorkshop #Southampton www.ukmgeworkshop.org

One week to register your talk! We have 20 confirmed speakers but still have room for a few more. Why attend? Excellent panel of colleagues participating, talent recruiting event (see website) at no cost! Sharing appreciated

When things add up: environmental structure and microbial interactions drive antibiotic-resistance plasmid evolution. New paper from the lab, and the third chapter of Lars Zandbergen’s thesis! www.biorxiv.org/cgi/content/...

Come join us in Southampton! You need to register to participate (free registration!). To give everyone an opportunity to showcase their science, we extended the deadline for title submission to May 16. Share widely!

Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩 Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭! Please visit my lab's webpage for details about the position and how to formally apply.

It's incredible that a resistance integrative and mobilizable element can spread while also holding back their helper plasmids with such a clever trick! From @vincentburrus.bsky.social lab www.biorxiv.org/content/10.1...

New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!

New preprint alert! 🧫 Proud to share Aditi Batra's (former colleague at @schulenburglab.bsky.social) work on #AMR evolution in polymicrobial infections. We found that strain variation & bacterial interactions significantly influence how P. aeruginosa populations respond to antibiotics. #MicroSky

I was happy to play a small part in the preprint below, led by Liam Shaw, and which started as a group project in the EMBO workshop in Trieste back in 2023, organised by @alicele.bsky.social and @zaminiqbal.bsky.social

It was great to attend @microbiologysociety.org #Microbio25 and hear the fantastic talks by @gemmaatkinson.bsky.social @epcrocha.bsky.social @tatianadimitriu.bsky.social @davvi36.bsky.social @willpjsmith.bsky.social @charlotteechong.bsky.social @jbbruce.bsky.social Giuseppina Mariano & Matt Craske!

Looking forward to attending this conference for the 1st time and co-chairing this session with amazing speakers! Join us on 2 and 3 April and listen to @gemmaatkinson.bsky.social, @epcrocha.bsky.social , @tatianadimitriu.bsky.social and Tim Blower! #Microbio25

We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in: 1) Mucosal immunology and oral vaccine development my.corehr.com/pls/uoxrecru... 2) Microbiology my.corehr.com/pls/uoxrecru... Please share!

We have a 2-year postdoc position available in the Lind Lab at Umeå University, Sweden! Predicting and steering experimental evolution of antibiotic resistance in Pseudomonas aeruginosa. Reposts appreciated. umu.varbi.com/en/?jobtoken...

www.nature.com/articles/s41... In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements. #phage #plasmid #evolution #bacteria #plasmidbiology #MGE

Our preprint is now published www.science.org/doi/10.1126/...

An ICE, a PICI, and a phage walk into a cell… and start crosstalking. Interesting read on how MGEs juggle interactions like pros! 🦠 academic.oup.com/ismej/articl...

Excited to share that this preprint is now published @genomeresearch.bsky.social! 🎉 Check it out here: genome.cshlp.org/content/earl...

🚨PhD studentship opportunity! Bacteria protect themselves with a huge arsenal of defences, but does this affect how they gain new traits on plasmids? 🧫🦠💫 Apply for a funded 4y position with me @livuni-ives.bsky.social, @brockhurstlab.bsky.social @jojofoth.bsky.social & @multidefence.bsky.social ⬇️

Bonnie and Clyde phages 😎

Delighted to share the first peer-reviewed paper from our team @camvetschool.bsky.social where we investigate the ecological dynamics of Enterobacteriaceae in the human gut #microbiome: www.nature.com/articles/s41... @naturemicrobiol.bsky.social

Joy! Published today in PNAS: multi-toxin T6SS attacks limit resistance evolution in competitors! Big thanks to our wonderful team of collaborators for all their help: @coytelab.bsky.social @knightjar.bsky.social @basler-lab.bsky.social @brockhurstlab.bsky.social 🎉 www.pnas.org/doi/10.1073/...

What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...