Bye bye X, hello Bluesky !

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

Congrats to Kira Young who spearheaded this work & all contributing authors. This was a fun (and long!) collaboration with @marcmansour.bsky.social, @challenlab.bsky.social, @ericpietras.bsky.social, Kelsey Fisher-Wellman, @keisukeito-lab.bsky.social & Steven Chan

For my new followers! Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @bloodjournal.bsky.social, we’ve discovered a novel mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL.👇