This new @michellemonje.bsky.social preprint shows that #psilocybin promotes the rapid and persistent growth of... xenografted glioma in mice. 🫠 www.biorxiv.org/content/10.6... Enduring but maladaptive plasticity induced by #psychedelics. h/t @tylerekins.bsky.social @theborislab.bsky.social

Next-gen neuroplastogen developers be like

“Approval rates significantly declined from 2022 to 2024 [...] In 2022, 74 of the 90 (82%) requests were approved, followed by 123 out of 165 (74.5%) in 2023 and 107 out of 181 (59.1%) in 2024, even though the number of overall requests remained stable.” www.nature.com/articles/s44...

This Is Your Priest on Drugs?

One of my favorite resources & collaborative opportunities for those interested in the psychedelic field!! Amazing work!!

3 of my papers (2 preprints) made the list! Great resource and great for scoping out all that was published last year

📚✨ ~500 Papers. ~30 Researchers & Experts. One Annotated Psychedelics Bibliography... Very excited to share the 2024 edition of Psychedelic Alpha's Interdisciplinary Annotated Psychedelic Research Bibliography, by @michaelhaichin.bsky.social. psychedelicalpha.com/news/the-int...

Got interviewed by the Microdose newsletter on the intersection of #psychedelic and #placebo research and on why psychedelic research should revisit the long forgotten Zelen design to solve the "know-cebo" problem. Enjoy! themicrodose.substack.com/p/the-power-...

Our new review in JAMA Psychiatry: "Expectancy Effects, Failure of Blinding Integrity, and Placebo Response in Trials of Treatments for Psychiatric Disorders" jamanetwork.com/journals/jam... Thanks to co-first author Guil Fusetto-Veronesi; and to Samuele Cortese, David Baldwin, Matt Garner 🧵👇

New: The Q1'25 Edition of our Psychedelic Drug Development Pipeline Bullseye Chart is now available to download. Get an overview of psychedelic candidates by molecule type and phase of development via this handy visual. psychedelicalpha.com/news/q125-ps...

Psychedelic mental health research is booming—but how do we keep up with rapidly evolving evidence? 🌱 Our team proposes a living evidence synthesis approach to ensure clinicians, policymakers, and the public have access to the latest, most reliable data. 🔗 www.nature.com/articles/s44... 🧪🧵

5x5 for 2024 What were your 5 favourite albums, books, movies, podcasts, and TV shows this year? See below for mine, in no particular order. Quote this post and tell me yours!

"Navigating this new world will require a more precise understanding of the psychoactive substances that are now part of it. Instead of attempting to sort chemical compounds into good and bad, we could pay more attention to how people use them." - @mikejay.bsky.social www.nytimes.com/2024/12/23/o...

Thought-provoking chapter about the integration of psychedelics into society: academic.oup.com/book/58175/c... TL;DR 10-year trial period privately funded w/ a new type of insurance and only two doses of psilocybin per year per adult available in protected spaces following psychiatric screening.

I spoke with Javier Muniz, MD, who just left his role as Associate Director at FDA's Division of Psychiatry, about all things psychedelics. psychedelicalpha.com/news/inside-...

Another NMDA antagonist for depression bites the dust… Is it still a viable target?

New paper! This was a fun lil collaboration with Maastricht University in which we thought we might find evidence that ayahuasca would increase false memory in an observational study. WRONG! Ended up enhancing memory (but read 'til end for caveats) journals.sagepub.com/doi/10.1177/... 1/8

Psychoactive-controlled ketamine for OCD study doi.org/10.1177/0269... "We did not assess blinding...prominent differences in dissociation scores...suggest that fentanyl 50 μg also did not provide an adequate blind...would not recommend its use (but do not have a suitable alternative to recommend)."

Psychoactive-controlled ketamine for OCD study doi.org/10.1177/0269... "We did not assess blinding...prominent differences in dissociation scores...suggest that fentanyl 50 μg also did not provide an adequate blind...would not recommend its use (but do not have a suitable alternative to recommend)."

Benjamin Labatut is one of the most amazing writers I’ve ever read! If you haven’t, please check “The day we ceased to understand the world” and “Maniac” His interviews are also mind blowing: youtu.be/E-OFnHwuTBg?...

A new preprint for my new BlueSky homies: "Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically" www.researchgate.net/publication/...

I don't know who made this #psychedelics paper one but I love it so much I framed a copy for my office

Hi 🦋 1) Medical Advisor to Psychedelic Alpha 2) 2024 Interdisciplinary Annotated Psychedelic Research Bibliography (psychedelicalpha.com/news/2023-an...) - let me know if you'd like to participate 3) Just finished There's Always This Year - the most beautifully written non-fiction I've come across