Congrats to the authors on this huge accomplishment. Fascinating and so much to build on here.

Has anyone had success 3D printing storage boxes for -80s? What fiber have you used? any special settings to reinforce? I'm thinking of making either custom inserts or entire boxes to better keep track of which sample goes where...

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

Reminds me of Oliver Sacks’ musings on seeing azure. This will surely be commercialised and available as an “experience” (hopefully safely) around the world soon, but absolutely sign me up.

I think the reason I like #systemsimmunology #cshlsysimm is because network diagrams are so pretty.

This is simply insanity.

This disc is a revelation. I thought I knew these pieces-the D minor concerto was one of the first pieces I fell in love with as a kid. Beatrice Rana’s playing is simply enchanting.

Does anyone have experience with momelotinib for AGvHD in MF patients?

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested! aprecruit.ucsf.edu/JPF05438

Excited to attend #cshlsysimm next week. I am just starting to find my way in this fascinating field and look forward to learning from the extraordinary lineup of speakers! Please reach out if you’ll be there—looking forward to connecting. @cshlnews.bsky.social

I remain strongly in favor of fishing expeditions.

In light of recent news regarding funding, I have asked ChatGPT to help figure out how to do ATAC-Seq with only an abacus and stone tools.

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

It dawned on me today that I really should’ve named one of my kids Luke, so that I could legitimately say “Luke, I am your father.” Oh well.

Today is another Chopin day. Thank you, Maurizio Pollini. music.apple.com/us/album/pia...

Highly recommended escape from these dark times.

1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...

Having determined that the transplant immunology community is shamefully lacking for pompously named journals, I propose the establishment of Acta Transplantiana A (solid organs) and B (haematopoietic tissues). Paper distribution only, on heavy cream-coloured paper stock. Figures hand-drawn.

I am struck by the aptness of Fareed Zakaria’s description of the United States in this conversation with @ezraklein.bsky.social We are determined to devour the world that we created. podcasts.apple.com/us/podcast/t...

If someone thinks the measles outbreak and childhood death in Texas are "not unusual" or "happens all the time", they are deeply misinformed. h/t @adamratnermd.bsky.social for the inspiration. blogs.jwatch.org/hiv-id-obser...

A compendium of human gene functions derived from evolutionary modelling @nature.com www.nature.com/articles/s41...

Anyone have a nice public dataset of shotgun gut microbiome data specifically in GU malignancies treated with checkpoint inhibitors? Looking for something with published OS or PFS data for a little validation. Much obliged!

More attacks on US science by stealth as new research grants still frozen! Grants issued via 2 step process- one to assess science via science board and one a grant review step with a membership of a wider board that get final approval to sign the money of based upon initial recommendation 🧪🧵

What a wonderful #Tandem25! As always, the best of the conference is in the conversations and brainstorming between and outside the sessions; so wonderful to reconnect with mentors, friends, acquaintances from around the world in one of the most beautiful places I have ever visited.

#tandem25 #bmtsm Abrams: exclusion from HCT/CT most commonly due to lack of insurance, unhoused, medication non-adherence, and substance abuse. Broad variability in abstinence time requirements. Top center-reported barriers to all HCT/CT were lack of caregiver and housing concerns.

Enough said. Decisions matter.

#tandem25 #bmtsm Arnhold: we aren’t at the point where we can abandon steroids in aGVHD, but it’s as clear as ever that that needs to be a high priority for innovation in GVHD care.

Finally, REALLY USEFUL science. An entire beautiful article on how to perfectly cook an egg. h/t @nytimes.com . www.nature.com/articles/s44...

Take advantage of the opportunity to speak at the Mini Symposium by submitting an abstract by 26 February. Learn how and register today ➡️ https://buff.ly/3WLixTV

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

Looking forward to @moritzgerstung.bsky.social seminar @uob-ieu.bsky.social on 30th Jan 2025 at 1pm, ,“ Using AI to Predict Disease Risks” in person and on line bristol-ac-uk.zoom.us/j/94273829130

Anyone have a secret stash of brincidofivir they can share? FDA will release for monkeypox but not for adenovirus. Just in case we have a global smallpox outbreak and need every last dose from the strategic national stockpile.

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet! 🎉 👩🏻‍🔬 They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5 www.nature.com/articles/s41...

This looks intriguing and conveniently well timed for me to test on a dataset I’m playing with. Anyone have experience with this tool from a preprint or whatnot and have reflections to share?

The big 4 of grant writing: 1. Credibility: The topic fits your expertise 2. Narrative: It's clear what is the problem, the solution, and why you’re the right person for it 3. Juicy details: Flex your mastery of the topic 4. The concept: You connect every part to the big question

Many pediatric oncology programs rely on philanthropy and have just a small fraction of the resources that St Jude has. If you’d like to support children with cancer, especially those in your area, consider donating to your local children’s hospital.

Whether you’re a seasoned pianist, occasional classical music listener (“background music”) or resolute in your belief that there was no such thing as music before 1968… I implore you to take an hour to listen to this segment of the Chopin Podcast, *working through* the Barcarolle. Brilliant.

OUTSTANDING #ASH24 roundup of lymphoma (esp. MCL) abstracts. Is auto dead for MCL? And… not addressed, should we still consider (early) allo for young high-risk? @ash-hematology.bsky.social @berninini.bsky.social (can’t find Anthony Perissinotti or Tycel Phillips here yet? Please tag if they are!)

My gingerbread for this year. Merry Christmas and happy Voyages to all!!

When a student's reading list gets out of control...📚🎄

The world's richest man managed to take $190 million away from a *child cancer research center* with his posts yesterday. Funding now stripped in the new bill.

Pondering a provocative question Saar Gill asked at #ASH24 - should we be able to use allo #bmtsm 💣 for GvT in highly selected pts w solid malignancies?

Congrats @nursariipek.bsky.social!

🤯

#bluetoirial courtesy of @mskcancercenter.bsky.social Roni Shouval Now out in #BloodCancerDiscovery Comprehensive study (n=263) on immune reconstitution after CD19 #CARTcells (axi/liso/tisa-cel) in LBCL. Led by the talented @DannyLuan6 #Lymphoma #NKcells #lymsm 1/6 aacrjournals.org/bloodcancerd...

Breaking the mold: Unconventional T cells in cancer therapy: Cancer Cell www.cell.com/cancer-cell/...

It’s been 13 years since I started down the road to a medical career and left music behind… but I’m delighted to say that last night I had my got to sing on a stage again for the first time in about a decade! Hoping to make time for voice lessons and occasional performing as an attending

Excited to share our new publication identifying unique features of CD56bright NK cells in HSCT recipients. Here we explore unique features of CD56bright NK cells in HSCT recipients protected from GVHD, and identify factors that shape their functions: www.cell.com/iscience/ful...

#ASH24 time to start watching the videos or all the things I couldn’t catch in real time. Here’s my annual request for recommendations—what talks wowed you this year?