What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...

Now that the lab has stuff in it, I’m looking for a postdoc. Must have: - Mouse experience (several years ideally) - Cell culture experience - An interest in T cells - Team player Bonus points for: - any flow experience - any scRNAseq exp (wet or dry) - CAR T manufacturing

Seeing my colleagues succeed brings me so much joy. Can’t wait for the ‘proud PI’ moments to come from my lab. I’ve already asked my trainees how they like to receive recognition and they are both the quiet email types. This will be a challenge…gotta rein it in!

Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation | Journal of Clinical Oncology ascopubs.org/doi/10.1200/...

The best advice I received about hiring was always hire people smarter than yourself. I’ve taken that very seriously, plus added my own criteria “vibes”, and I am so excited for the new Minnie Lab team members to start soon!!

Reminder: Not everything thought needs to be said Not everything said needs to be written Not everything written needs to go on social media

The astounding contribution of US academic science to new medicines www.statnews.com/2025/06/06/u...

How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social www.science.org/doi/10.1126/...

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested! aprecruit.ucsf.edu/JPF05438

Hiring freeze at the same time as starting a lab will keep things interesting. Got one hire through the door before it happened at least. This tech really wanted some hands-on training and boy are they going to get it 😂

Fred Hutch at #Tandem25: Catch presentations from Drs. Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L

I am beyond excited to be starting my lab at UCSF in May 2025. I'll be joining the Hematology/Oncology Division and working with the Myeloma Program (lead by @ajaichari.bsky.social) to advance immunotherapies and cellular therapies for myeloma!

Happy New Year! 2025 is going to be a big one!!

Hematologists please follow Ajai Chari, the very talented leader of the @ucsfcancer.bsky.social #myeloma program. #hematology bsky.app/profile/ajai...

What a win for myeloma research at Fred Hutch!!! Welcome Madhav!

Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers Sunday, Dec 8: 4:30 PM #ASH24 #leusm ash.confex.com/ash/2024/web...

This might just end up being a PNW nature shots account for the next couple of days 😅 It’s so beautiful here!

Break from scientific programming to say that the PNW is truly one of the most beautiful places I’ve ever lived!

This was one of the most useful courses I’ve ever done. Highly recommend. Don’t walk, run!!!

Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy www.nature.com/articles/s41...

Presenting this paper at journal club tomorrow and I’m actually so excited to share it with the lab. I’ve said it at the other place and I’ll say it here, it’s just a beautiful paper!!! www.nature.com/articles/s41...

If you're interested in Stem cell transplant and/or Cellular Therapy this is the list #bmtsm #CARTcells #leusm #mmsm #lymsm #MedSky #TcellRx go.bsky.app/7xxh8WW

Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay www.cell.com/cell-reports...

I think one of the most important parts of mentoring is having empathy for your trainees. Firstly, things being harder now for junior people doesn’t mean that things weren’t hard for you at the time. Ie. I would NEVER have gotten into a PhD program these days with my track record back then.

CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.

Current postdocs have the perception that the faculty job market is insanely hard right now. Is this reality? Has it always been this hard or is it objectively particularly bad right now?

Putting LIPSTIC on CARTs "We reasoned that target-induced labelling of CAR molecules within the immunologic synapse, instead of surface CD8 expression levels, could be used to distinguish and characterize first-division proximal- and distal-daughter CARTs" #Immunology www.nature.com/articles/s41...