This isn't even a slight exaggeration. He is actively working on destroying the US's entire vaccine infrastructure. The HepB vote will be tomorrow, where they will get rid of the birth dose and recommend it at 30 days, dooming a bunch of infants to chronic infection ft. cirrhosis, cancer, and death.

The chair of the #ACIP is a #COVID-contrarian, Martin Kulldorff, as are others on the committee (i.e., Robert Malone). COVID-contrarians also have hands on the lever of vaccine policy at #FDA (i.e., Vinay Prasad, Tracy Beth Hoeg), at #NIH (i.e., Jay Bhattacharya). 1/

9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American." It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...

Imgs from @johnshopkinssph.bsky.social on IG. In my experience, essentially all people want to work when their health allows. But not everyone can find a job. Making monthly work assessments part of maintaining bare minimum health insurance is a ruse to uninsure more Americans. Disgusting.

Why work when you can just get sick and be paid to take medications in tRump’s delulu version of America?

From Pink Sheet on continued departures from FDA’s biologics division and challenges backfilling openings. FDA biologics center reported 106 departures from Jan. 1 to June 30. These numbers don’t include the 100-150 who were part of the reduction-in-force insights.citeline.com/pink-sheet/a...

FDA’s cancer review team overseeing breast and gynecological products has lost about 1/3 of its medical review staff and the malignant heme group will lose about 2/3 of its medical review staff—all to voluntary resignations clustered among seasoned reviewers insights.citeline.com/pink-sheet/a...

Sadly, I’ve seen more public evidence in Latin America and Europe that people care about stopping a holocaust than I’ve seen anywhere in America… #feedpalestine

“Working” with ChatGPT is like having an emotionally abusive partner. (Hey OpenAI: the fabrication of references problem has been known for a long time now. Preventing your bot from creating fake references with real PMID numbers that are verifiably wrong with one click should be easy…)

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...

Amazing analysis and terrible implications for research in the US. Very impactful research is being eliminated. Worth a look. The Gutting of America’s Medical Research: Here Is Every Canceled or Delayed N.I.H. Grant www.nytimes.com/interactive/...

#ASCO25 is going great so far. I love how walkable Chicago is day and night this time of year. Seriously, if anyone knows a place that has the same vibe and weather as late May in Chicago — but year-round — please let me know, because I want to move there!

#ASCO25 Arce-Ruiz: identified ~30K w CH vs 440K wo CH in Biobank DB. Age-related macular degeneration (AMD) appears to be modestly assoc w CH (HR 1.15) but no specific gene mutation indicted as culprit. CH not assoc w vision loss in those with AMD.

#ASCO25 #mpnsm Arce-Ruiz: Macular degeneration in pts w clonal hematopoiesis.

#ASCO25 #mpnsm Andorsky: Asciminib in 2L CML (wo T315I), n=101, treatment ongoing in 91%. 82.5% achieved BCR-ABL <0.1%, 44% MMR at 24wks. Only 3% had AEs leading to discontinuation. Study ongoing.

#ASCO25 #mpnsm Andorsky: Asciminib in 2L treatment of CML (wo T315I). Reason for dc 1L TKI was lack of efficacy in 57% and intolerance 43%.

#ASCO25 #mpnsm Mascarenhas: Imetelstat + Ruxolitinib in Int1/2- and HR-MF. Combo well tolerated with low incidence of tcp. Significant redxn in sx burden and spleen size. Also decreased VAF of driver mutations w combo at Imetelstat RP2D.

#ASCO25 #mpnsm Mascarenhas: Imetelstat + Ruxolitinib in Int1/2- and HR-MF.

#ASCO25 #leusm Goldfinger: Metronomic (weekly) DAC/Ven appears favorable in TP53m MDS/AML vs historical controls (~1/3 of whom recd conventional HMA/Ven). Low rate (12.5%) of febrile neutropenia with metronomic dosing.

#ASCO25 #leusm Goldfinger: Metronomic (weekly) DAC/Ven in TP53m MDS/AML. Median OS 11mos. Responses probably (small n) better with monoallelic TP53m.

#ASCO25 #leusm Goldfinger: Dosing Decitabine and Ven for terminal differentiation in MDS/AML. Typical dosing relies on TP53 activity. Metronomic dosing (once weekly for both DAC/Ven) may be TP53 independent. Prelim data favorable. Today presenting data on those w TP53m.

#ASCO25 #mdssm Daver: Bexmarilimab in HR-MDS has excellent safety profile (13% dc for TEAE, IrAEs in 4%). ORR 72% in 1L, 63% in relapse. Encouraging responses in TP53m setting as well.

#ASCO25 #mdssm Daver: Macrophage checkpoint Clever-1 inhibition with Bexmarilimab (w Aza) in HR-MDS. Clever-1 involved in conversion of macrophage to pro-inflammatory phenotype.

#ASCO25 #mdssm Garcia-Manero: transfusion independence 76% with Luspa vs 56% with epo with median DOR and 150 vs 95wks. Median OS not NR with Luspa yet vs 46mo with Epo.

#ASCO25 #mdssm Garcia-Manero: survival and duration of response update (median f-up >2.5yr) on COMMANDS trial of Luspatercept vs Epo in LR-MDS. Median tx duration 71.5 vs 44 wks.

#ASCO25 #leusm Desai: lower dose PTCy assoc with fewer bloodstream infections — 30% vs 59% at D30 — and fewer CMV reactivations — 19% vs 7% at D100. Also less volume overload (fluid toxicity) with lower dose PTCy.

#ASCO25 #leusm Desai: lower dose PTCy (70) assoc with slightly faster engraftment and no diff in GVHD incidence vs standard (100).

#ASCO25 #leusm Desai: Reduced dose PTCy (70 v 100mg/m2) after allo for AML using MUD. PTCy reduces GVHD but will assoc w high infxn risk. This single center study evald lower total Cy dose (with low dose ATG).

#ASCO25 #leusm Aldoss: MRD negativity after end of induction with chemo+Ponatinib on PhALLCON trial. 56% w Ponat vs 69% with Imat not MRD neg at EOI. In those not MRD neg at EOI, superior OS in those receiving Ponat.

#ASCO25 #leusm Luskin: Asciminib+Dasatinib+Pred+Blin for newly dx Ph+ ALL. No relapses this far.

#ASCO25 #leusm Luskin: Asciminib+Dasatinib+Pred+Blin for newly dx Ph+ ALL. Asciminib well Tolerated. Dasatinib dose redxn more common. 100% flow neg CR 85% NGS neg.

#ASCO25 #leusm Luskin: Asciminib+Dasatinib+Pred+Blin for newly dx Ph+ ALL.

Along the same lines of conscientious consumerism that led me to dump Tesla, I have also stopped ordering from Amazon. It was a tough change, for sure, because I used to receive AMZN deliveries more days of the month than not. But it can be done. I’ve received nothing from AMZN for over 2 months.

I posted this about Israel’s destruction of civilian healthcare infrastructure in Gaza on instagram and it was censored. We are not free. Those of us who wish to see crimes against humanity prosecuted are silenced.

These stories landed today, within 11 hours of each other. This presidential administration is a clear and present danger to the American people.

The end of an era. Today, I returned my third and last Tesla. The only real power we have is where we spend our money. I have been driving Tesla vehicles for over ten years and have contributed to them selling many, many vehicles, but I will no longer support Elon. #resist #defundtesla #defundelon

It was an extreme privilege to speak at the Emirates Society of Hematology Annual Conference this past weekend. Here with some of the other UAE, EU, and US faculty beneath the Burj Khalifa (so tall it couldn’t fit in the photo 😂).

Hear me out… The future is what we make of it. I hope Canada’s leadership recognizes the potential of the greater Vancouver metro area. Build it and we will come.

So many amazing researchers, scientists and clinicians there - that this seems unfathomable.

Today would be yet another good day for university presidents to loudly, collectively, & publicly start defending our institutions & industry. The silence is deafening & frankly, incomprehensible. What exactly are you waiting for? How many Columbias, Maines, & Johns Hopkins will it take?

We live in a society exquisitely dependent on science and technology, in which hardly anyone knows anything about science and technology. Carl Sagan (1934 - 1996)

UMASS IS RESCINDING ALL GRAD POSITIONS FOR THIS YEAR

Sobering statistic! From Gallup: ~31 million Americans report they had to borrow an estimated total of $74 billion in the past 12 months to pay for healthcare for themselves/household member. Timely data since Medicaid/Affordable Care Act cuts are being discussed. news.gallup.com/poll/657041/...

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

Because 👏 science 👏saves 👏 lives👏 Amazing to see everyone come together today at the @standupforscience.bsky.social rally! ASH is here to protect science and advocate for the funding and support that drives innovation in #hematology and beyond. 💪🩸

I just happen to have this hour free (instead of being in my normal Friday clinic @ucsfcancer.bsky.social), so here I am to #standupforscience.

Medicaid is not for sale. NASA is not for sale. The Post Office is not for sale. America is not for sale. We have an obligation to resist kings. We outnumber them. And they can be overwhelmed.

Physicians at the VA received these as well.