Some tremendous photography on this site showing the everyday beauty around us. We make the world around us, so I will try to contribute in my own little way… This is not the Carribean, Fiji, or the Med. This is southwest Michigan!

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

🚨 Last week to apply for AAS Student Travel Awards! Both awards provide travel funding to attend the AAS Annual Meeting, connect with leaders in the field, and advance your academic surgery career. 📅 Deadline: September 5, 2025 Don’t miss your chance! Apply today: www.aasurg.org/awards/stude...

What to do with carcinoid crisis? 🦓 A frequent concern for patients with #NETs having surgery We put together an international 🌎🌍🌏 multidisciplinary expert consensus statement 📢 Now open for feedback! Sign-up here 🔗 surveymonkey.com/r/periopcarc... 📆 Open until March 3rd!

Having funded teams/contracts that required six figure+ funds a few times now, these numbers SOUND really huge in isolation to normal folks but they're not! Don't make floating numbers! I like to say things like this: "A cancer lab is basically a small business, with many jobs created by each grant"

Kluivert is on fire! Cherries FTW again! #afcbournemouth #premierleague

War Cherries FTW!!! #FAcup #AFCBournemouth

Hot take (or lukewarm…): with “AI” models predicting all sorts of genome/chromatin phenomena, it’s important to remember that these are still models! Experimental validation remains hard and is still key! #GeneRegulation #GeneSky #Chromatin

Yes it's important people understand a preprint hasn't been peer-reviewed. BUT it's also important to understand that what "peer-reviewed" means varies considerably, in some cases signifying nothing... www.science.org/content/arti...

1/Happy new year from the Metastasis Research Society! As we close out 2024, here are some additional studies that have shaped our understanding of metastasis biology this year. 🧵...

For anyone reading blogs over the holiday: Despite claims that the lecture is (or should be) dead, we'll still be doing it for the foreseeable future. So, we might as well do it well. Some tips based on my career of gradually sucking less: scientistseessquirre...

Bluetorial: Mentors III The tall chemist from Nantucket My PhD thesis advisor was a great synthetic chemist and a true scholar. He gave me freedom to pursue my dissertation research. Lots of chemistry today. And a surprising and somewhat distressing ending.

only just learned that using "from:me" in the search bar along with whatever phrases you're looking for is the way to look for posts on here that were made by you and I feel like I'm not the only one who didn't realize that and would probably be glad to know such a function exists

Commencing the FA portion of FAFO. To be soon followed by … FO, of course! www.npr.org/sections/sho...

All sorts of winning happening this morning in my office! Thanks to the unnamed journal sending a friendly SECOND notice for a review of a manuscript, which isn’t due until a week from today! Gee, I almost forgot after the first one… (Narrator: he didn’t forget…)

Wanna talk about why patients and doctors are angry and tired of health insurance companies? I just spent 15 minutes of my day across two phone calls with two humans and one robot to appeal a denial of a CT scan for a cancer patient. The CT is a standard of care in their case. 1/2

One thing that all professors have in common in that we weren't trained for our jobs. Now that I've been doing this for a few decades, I'm starting an occasional series called Professor School. It's not advice, just bunch of ideas and information to make things easier. 🧪

💯 yes!

Wow!

Cool analysis of large public scRNA-seq datasets and how stringent our approaches should be to scRNA-seq quality control. The DropletQC paper from 2021 may not currently have as many citations as expected, but the idea is sound and good ideas stand the test of time. This work supports this notion!

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

The danger theory of immunity strikes back... rdcu.be/d1uQN

Starter packs are fab, but skew towards established folks Cue intros into all the amazing people in our lab… give them a follow 🚶 First up Marzia Munafo. Leading a spectacular oocyte epigenomics project (watch this space 👀) and science illustrator extraordinaire. Check out the beautiful works 👇👇

@sproullab.bsky.social has made chromatin starter packs!

Hello Bluesky, the Nogales lab is very excited to join this growing community 🦋 We look forward to sharing our work here and to connect with other scientists!

Hello #SciSky 🧪! We're the Node, a community site for developmental and stem cell biologists, hosted by @dev-journal.bsky.social This is your site: once you’ve registered, you can share your blog post, job advert or event notice with the #DevBio and #StemCell community. thenode.biologists.com

Public Service Announcement: Check colorblind-compatibility in Illustrator! Under 'View', 'Proof Setup' you can selected a colorblindness type to view your image in that spectra. Click 'Proof Colors' after to remove filter. We chose pink/green, yellow/blue here for accessibility (PMID 38112643).

And as this gains attention outside of scientific circles, as it surely will, @deevybee.bsky.social will undoubtedly face a great deal of harassment. Other fellows of the @royalsociety.bsky.social will have to decide whether she faces it alone or not.

🤣

This is a tour-de-force review for anyone semi-seriously interested in chromatin biology! It discusses functionality of chromatin within the physical constraints of its structure and folding! Well worth the read! (and it took me four hours to parse through it and think about it. I read slowly…)

Early morning summit - Bell Rock Trail, Sedona, Arizona

Early morning view!

Good morning!

The first review article from my lab, helmed by @celiasouque.bsky.social, "From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance" is now online and open access at Annual Reviews Microbiology: www.annualreviews.org/content/jour...

Today’s moment of Zen…

Finally had a bit of time to put together the story of our new paper that was published earlier this week in CMGH. 1. Read the TLDR next. 2. If you want more, stay for the full story behind this work. www.cmghjournal.org/article/S235... #MedSky #SurgSky #HPBSky #Science

PIONEERS When I assumed the position as Director of NIGMS in 2003, Dr. Zerhouni's project for stimulating activities across NIH, The NIH Roadmap for Medical Research, was under active development. The Roadmap included a range of different funding opportunities. 1/n www.science.org/content/arti...

If you don’t know about Ben Barres’ scientific legacy, here is a magnificent recounting of just one facet. Ben Barres was a true pioneer in so many different ways (Barres’ demonstration of immune complement mediated synaptic pruning in brain development is 🤯) And if you do, please help document it!

Today #JAMAsurg: long term outcomes #ESCAPE RCT: early #surgery remains superior to #endoscopy first in pts with wide-duct #chronic #pancreatitis ✅ Lower Izbicki pain scores ✅ Lower number of reinterventions ✅ Lower VAS pain scores ✅ Higher patient satisfaction ▶️ jamanetwork.com/journals/jam...

Today is the World Pancreatic Cancer Day. Although we have slowly increased 5-year survival from 5% to 12-13% in the last 20 years, there are reasons for optimism: - KRAS inhibitors - tumor vaccines - more effective chemotherapy - surgery for oligometastatic dz And much more! #MedSky #SurgSky

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

I read, um, a bit. Usually about a book a week. And these are, IMHO, the top ten books for data journalists or anyone curious about new ways of finding great stories🧵: (I will share more genres later.) Please LMK if there are others you would recommend! #Rstats #journalism #news

Clinical Cancer Research is now accepting nominations for our Early Career Award. Award recipient will be invited to the Journals Reception & the President’s Reception during the AACR Annual Meeting. A cash prize of $1,500 & a certificate will be given to the awardee. Find out more. bit.ly/3ANzCow

A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n

Ruth Kirschstein was an amazing person. She was deeply caring, had an incredible work ethic, high standards, and tremendous leadership skills. She was the first woman to lead an NIH Institute and served as Acting Director of NIH twice. Free biography of Dr. K. at www.nih.gov/sites/defaul... 5/n

Carl Sagan nailed it back in 1995.

1. Every patient with a suspected HPB malignancy should be evaluated by an HPB surgeon. The patient deserves an expert opinion. 2. In adults, jaundice is a surgical disease until proven otherwise (that’s easy based on LFT pattern). #surgsky 🦋

Hello. We are here #surgsky #surgedsky